Detalhe da pesquisa
1.
Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex.
J Biol Chem
; 293(43): 16761-16777, 2018 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30206124
2.
Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2'-C-methyl-6-O-methyl guanosine nucleoside and L-Alanine ester phosphoramidates.
Bioorg Med Chem Lett
; 23(7): 2260-4, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23453067
3.
Orally efficacious lead of the AVG inhibitor series targeting a dynamic interface in the respiratory syncytial virus polymerase.
Sci Adv
; 8(25): eabo2236, 2022 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35749502
4.
Pharmacokinetics and safety of FV-100, a novel oral anti-herpes zoster nucleoside analogue, administered in single and multiple doses to healthy young adult and elderly adult volunteers.
Antimicrob Agents Chemother
; 55(6): 2847-54, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21444712
5.
INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.
Antimicrob Agents Chemother
; 55(5): 1843-51, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21357300
6.
Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.
Bioorg Med Chem Lett
; 20(16): 4850-4, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20637609
7.
Multicenter study to assess safety and efficacy of INH-A21, a donor-selected human staphylococcal immunoglobulin, for prevention of nosocomial infections in very low birth weight infants.
Pediatr Infect Dis J
; 24(10): 858-66, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16220082
8.
Expression of staphylococcal clumping factor A impedes macrophage phagocytosis.
Microbes Infect
; 6(2): 188-95, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14998517
9.
MSCRAMM--targeted vaccines and immunotherapy for staphylococcal infection.
Curr Opin Drug Discov Devel
; 7(2): 223-7, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15603256
10.
Immunotherapeutics for nosocomial infections.
Expert Opin Investig Drugs
; 13(6): 673-9, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15174953
11.
Antibody response to the extracellular adherence protein (Eap) of Staphylococcus aureus in healthy and infected individuals.
FEMS Immunol Med Microbiol
; 62(1): 23-31, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21251089
12.
Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.
J Med Chem
; 54(24): 8632-45, 2011 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22039920
13.
Monoclonal antibodies specific for Candida albicans Als3 that immunolabel fungal cells in vitro and in vivo and block adhesion to host surfaces.
J Microbiol Methods
; 78(1): 71-8, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19427882
14.
A panel of monoclonal antibodies recognizing the Staphylococcus epidermidis fibrinogen-binding MSCRAMM SdrG.
Hybridoma (Larchmt)
; 26(1): 28-34, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17316083
15.
Monoclonal antibodies recognizing the Enterococcus faecalis collagen-binding MSCRAMM Ace: conditional expression and binding analysis.
Microb Pathog
; 43(2-3): 55-66, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17521860
16.
Will we ever see the approval of a Staphylococcus aureus vaccine?
Expert Rev Anti Infect Ther
; 9(10): 845-6, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21973294
17.
Phase I dose escalation study to evaluate the safety and pharmacokinetic profile of tefibazumab in subjects with end-stage renal disease requiring hemodialysis.
Antimicrob Agents Chemother
; 50(10): 3499-500, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17005843
18.
Human immunoglobulin G recognizing fibrinogen-binding surface proteins is protective against both Staphylococcus aureus and Staphylococcus epidermidis infections in vivo.
Antimicrob Agents Chemother
; 50(2): 511-8, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16436704
19.
Phase II, randomized, double-blind, multicenter study comparing the safety and pharmacokinetics of tefibazumab to placebo for treatment of Staphylococcus aureus bacteremia.
Antimicrob Agents Chemother
; 50(8): 2751-5, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16870768
20.
Open-label, dose escalation study of the safety and pharmacokinetic profile of tefibazumab in healthy volunteers.
Antimicrob Agents Chemother
; 49(3): 959-62, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15728889