Detalhe da pesquisa
1.
Metabolism, pharmacokinetics and excretion of [14C]dimethyl fumarate in healthy volunteers: an example of xenobiotic biotransformation following endogenous metabolic pathways.
Xenobiotica
; 53(3): 163-172, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-37216617
2.
Discovery of biaryl carboxylamides as potent RORγ inverse agonists.
Bioorg Med Chem Lett
; 25(15): 2991-7, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048806
3.
Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions.
Drug Metab Dispos
; 41(8): 1566-74, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23723360
4.
Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals.
Drug Metab Dispos
; 40(3): 426-35, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22106171
5.
The kinetic mechanism for cytochrome P450 metabolism of type II binding compounds: evidence supporting direct reduction.
Arch Biochem Biophys
; 511(1-2): 69-79, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21530484
6.
The effects of type II binding on metabolic stability and binding affinity in cytochrome P450 CYP3A4.
Arch Biochem Biophys
; 497(1-2): 68-81, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20346909
7.
Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective.
AAPS J
; 22(6): 123, 2020 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32981010
8.
Correction to: Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective.
AAPS J
; 23(1): 6, 2020 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33244667
9.
High confidence predictions of drug-drug interactions: predicting affinities for cytochrome P450 2C9 with multiple computational methods.
J Med Chem
; 51(3): 648-54, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18211009
10.
Modeling and synthesis of novel tight-binding inhibitors of cytochrome P450 2C9.
Bioorg Med Chem
; 16(7): 4064-74, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18255300
11.
A Novel Plated Hepatocyte Relay Assay (PHRA) for In Vitro Evaluation of Hepatic Metabolic Clearance of Slowly Metabolized Compounds.
Drug Metab Lett
; 10(1): 3-15, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26282592
12.
Direct protein-protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1.
FEBS Lett
; 590(16): 2527-35, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27416800
13.
Cytochrome P450 2C9 type II binding studies on quinoline-4-carboxamide analogues.
J Med Chem
; 51(24): 8000-11, 2008 Dec 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19053752