Assuntos
Comportamento de Escolha/ética , Experimentação Humana/ética , Obrigações Morais , Autonomia Pessoal , Gestantes , Sujeitos da Pesquisa , Beneficência , Ensaios Clínicos como Assunto/ética , Ética em Pesquisa , Feminino , Morte Fetal , Feto , Humanos , Pacientes , Relações Médico-Paciente/ética , Gravidez , Relações Pesquisador-Sujeito/ética , RiscoRESUMO
In experimental decerebration of mammals, the cerebral cortex and thalamus are surgically or otherwise inactivated under traditional (pharmacologic) general anesthesia. Once the effects of the pharmacologic anesthesia have dissipated, the animal remains alive, but there is neither pain sensation nor consciousness. Because the Animal Welfare Act and its regulations recognize drugs as the only means to alleviate pain, it is unclear whether a decerebrate animal should be placed in U.S. Department of Agriculture (USDA) pain and distress category D (pain or distress alleviated by drugs) or E (unalleviated pain or distress). We present a rationale for including decerebrate animals in USDA category D. We also provide a general review of decerebration and suggestions for institutional animal care and use committees having to evaluate decerebration protocols.
Assuntos
Experimentação Animal , Bem-Estar do Animal/normas , Encéfalo/cirurgia , Estado de Descerebração/veterinária , Ciência dos Animais de Laboratório/métodos , Mamíferos , Dor/veterinária , Comitês de Cuidado Animal , Animais , Dor/classificação , Estados Unidos , United States Department of Agriculture/normasRESUMO
A visiting scholar from the School of Philosophy of Leeds University, England, was invited to participate in a seminar at the Section of Bioethics of Drexel University School of Medicine, which discussed (a) ethical differences between socialized and HMO systems, (b) physician-assisted suicide, (c) reproductive technology, (d) triage and rationing, and (e) organ donation and sale.