Detalhe da pesquisa
1.
Structural basis for substrate selection by the SARS-CoV-2 replicase.
Nature
; 614(7949): 781-787, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36725929
2.
Viral Resistance Analyses From the Remdesivir Phase 3 Adaptive COVID-19 Treatment Trial-1 (ACTT-1).
J Infect Dis
; 228(9): 1263-1273, 2023 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37466213
3.
Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir.
J Biol Chem
; 298(2): 101529, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34953856
4.
Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases.
Proc Natl Acad Sci U S A
; 117(43): 26946-26954, 2020 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33028676
5.
An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15.
J Biol Chem
; 297(4): 101218, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34562452
6.
In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance.
Antimicrob Agents Chemother
; 66(7): e0019822, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35708323
7.
Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants.
Antimicrob Agents Chemother
; 66(6): e0022222, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35532238
8.
The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2.
Molecules
; 27(13)2022 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35807457
9.
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action.
J Biol Chem
; 295(47): 16156-16165, 2020 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32967965
10.
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency.
J Biol Chem
; 295(20): 6785-6797, 2020 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32284326
11.
Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi® and Epclusa®.
Bioorg Med Chem Lett
; 29(16): 2415-2427, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31230974
12.
Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).
Bioorg Med Chem Lett
; 28(3): 541-546, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29254643
13.
Correction: Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action.
J Biol Chem
; 297(2): 101048, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34371377
14.
Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus.
Antimicrob Agents Chemother
; 60(2): 806-17, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26596942
15.
No Remdesivir Resistance Observed in the Phase 3 Severe and Moderate COVID-19 SIMPLE Trials.
Viruses
; 16(4)2024 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38675889
16.
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex.
Nat Struct Mol Biol
; 29(3): 250-260, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35260847
17.
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.
Sci Transl Med
; 14(656): eabo0718, 2022 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35482820
18.
Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.
Antimicrob Agents Chemother
; 55(6): 2905-15, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21464257
19.
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
J Med Chem
; 63(18): 10188-10203, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32407112
20.
Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.
bioRxiv
; 2020 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32511392