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1.
Proc Natl Acad Sci U S A ; 120(42): e2309076120, 2023 Oct 17.
Artigo em Inglês | MEDLINE | ID: mdl-37816051

RESUMO

Despite the ubiquity of tropical cyclones and their impacts on forests, little is known about how tropical cyclone regimes shape the ecology and evolution of tree species. We used a simple meteorological model (HURRECON) to estimate wind fields from hurricanes in the Western North Atlantic and Eastern North Pacific tropical cyclone basins from storms occurring between 1851 and 2022. We characterize how the intensity and frequency of hurricanes differ among geographically distinct hurricane regimes and define four hurricane regimes for North America (Continental, Inland, Coastal, and Fringe). Along this coastal-to-inland gradient, we found major differences in the frequency and intensity of hurricane wind regimes. The Fringe regime experiences category 1 winds relatively frequently [return period (RP) 25 y], whereas the Inland regime experiences category 1 winds very infrequently (RP ~3,000 y). We discuss how species traits related to tree windfirmness, such as mechanical properties and crown traits, may vary along hurricane regime gradients. Quantitative characterization of forest hurricane regimes provides a critical step for understanding the evolutionary and ecological role of hurricane regimes in wind-prone forests.

2.
Oecologia ; 197(3): 795-806, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34613464

RESUMO

Humans are transforming the ecology of the Earth through rapid changes in land use and climate. These changes can affect tropical forest structure, dynamics and diversity. While numerous studies have focused on diversity metrics, other aspects of forest function, such as long-term biomass dynamics, are often less considered. We evaluated plant community structure change (i.e., abundance, diversity, composition, and aboveground biomass) in a 2.25 ha forest dynamics plot located within a ~ 365 ha reserve in southern Costa Rica. We censused, mapped and identified to species all plants ≥ 5 cm diameter at breast height (DBH) in three surveys spanning 2010-2020. While there were no changes in late-successional species diversity, there were marked changes in overall species composition and biomass. Abundance of large (≥ 40 cm DBH) old-growth dense-wooded trees (e.g., Lauraceae, Rosaceae) decreased dramatically (27%), leading to major biomass decline over time, possibly driven by recent and recurrent drought events. Gaps created by large trees were colonized by early-successional species, but these recruits did not make up for the biomass lost. Finally, stem abundance increased by 20%, driven by increasing dominance of Hampea appendiculata. While results suggest this reserve may effectively conserve overall plant diversity, this may mask other key shifts such as large aboveground biomass loss. If this pattern is pervasive across tropical forest reserves, it could hamper efforts to preserve forest structure and ecosystem services (e.g., carbon storage). Monitoring programs could better assess carbon trends in reserves over time simply by tracking large tree dynamics.


Assuntos
Ecossistema , Árvores , Biomassa , Florestas , Humanos , Clima Tropical
3.
Qual Health Res ; 31(2): 218-227, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-33074053

RESUMO

A literature review was undertaken in 2019 to review research into the effectiveness of peer support in chronic disease self-management. As with an earlier literature review, we found the results disappointing due to poor reporting and poor research design. Lack of information on training of peer supporters, unrealistically short timeframes to produce changes in health behaviors, and lack of any theoretical underpinning of the research design contributed to rating randomized controlled trials as poor to medium quality evidence. At the same time, systematic reviews consider peer support as effective, arguing that improved research design and evaluation would demonstrate this. This article discusses the need to examine more closely the contribution of peer support to chronic disease care as well as considering how research methods might more closely reflect that contribution and provide better evidence of the value of peer support to both participants and the health system.


Assuntos
Aconselhamento , Grupo Associado , Comportamentos Relacionados com a Saúde , Humanos
4.
Epilepsy Behav ; 113: 107473, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33142200

RESUMO

AIM: Research examining quality of life (QoL) among people living with epilepsy (PWE) consistently highlights the detrimental impact of stigma, anxiety, and depression, as well as the dynamic and changing nature of QoL over time. This paper represents the first panel study of the Australian Epilepsy Longitudinal Survey (AELS), examining factors that influence the QoL of PWE over a six-year interval, particularly focusing on experiences of stigma, depression, and anxiety. METHODS: Ninety-two adults participated in both Wave 2 (T1; 2010) and Wave 4 (T2; 2016/17) of the AELS. Average age at T2 was 53.4 years [standard deviation (SD) = 15.3; range: 22-82; 55% female]. Over the study interval, there was a shift towards more younger participants moving out of high school and older participants moving into retirement. We explored the impact of (i) experiences of stigma, (ii) mood, and (iii) sociodemographic factors on QoL at both T1 and T2 via the use of correlation analyses. Hierarchical regression was used to determine the strongest predictors of QoL at T2. RESULTS: Occurrence of recent seizures, stigma, anxiety, and depression measured at T1 were all significantly correlated with total QoL at both T1 and T2. Sociodemographic factors including years of education, and weekly income before tax were not significantly correlated with QoL at either T1 or T2. QoL and depression at T1 were identified as the strongest predictors of QoL at T2 (six years later). DISCUSSION: The current study supports previous research highlighting the importance of psychological factors in understating QoL in PWE, particularly stigma, anxiety, and depression. In particular, it highlights the impact of depression on QoL over a 6-year interval, providing evident for the long-term nature of this relationship.


Assuntos
Epilepsia , Qualidade de Vida , Adulto , Ansiedade , Austrália , Pré-Escolar , Depressão , Feminino , Humanos , Masculino , Inquéritos e Questionários
5.
Epilepsy Behav ; 108: 107062, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32375096

RESUMO

AIM: This paper investigated the bases of needs for a range of epilepsy aids and equipment and expressed concerns about the use of such devices. METHOD: There was a 29.6% response rate (n = 393 of 1328) to Wave 4 of the Australian Epilepsy Longitudinal Study (AELS). The focus of Wave 4 was on the expressed needs and affordability of aids and equipment for people with epilepsy (PWE) and quality of life (QoL). Quantitative analysis was used to examine the association between self-reported need for aids and equipment, sociodemographic information, and QoL. Open-ended responses were subject to qualitative analysis. RESULTS: Approximately one-fifth of the sample felt that they needed specific aids, including emergency ID bracelets, seizure alarms, and seizure monitors. Those respondents who felt that they needed aids had more frequent seizures, had been recently injured by a seizure, and were less prosperous. The QoL of those in need of equipment was lower than that of those who felt that they did not need it. Qualitative analysis revealed a need for more information about the aids available, issues associated with affordability, and some concern about the utility of these aids for those who lived alone. DISCUSSION: Much research to date has focussed on the development and validation of devices for PWE and standards for testing. Fewer studies deal with the needs and experiences of PWE with regard to the use of such equipment. The development of these devices needs to ensure patient comfort and acceptability. In addition, there is a need to canvas the views of family, caregivers, and primary care providers on the usability of epilepsy aids and equipment. CONCLUSION: Further person-centered research is needed in assessing the need for and usability of aids and equipment for the management of epilepsy.


Assuntos
Gerenciamento Clínico , Epilepsia/epidemiologia , Epilepsia/psicologia , Equipamentos e Provisões , Necessidades e Demandas de Serviços de Saúde , Autorrelato , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Austrália/epidemiologia , Cuidadores/psicologia , Cuidadores/tendências , Estudos de Coortes , Epilepsia/terapia , Feminino , Pessoal de Saúde/tendências , Necessidades e Demandas de Serviços de Saúde/tendências , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Sistemas de Identificação de Pacientes/tendências , Dispositivos Eletrônicos Vestíveis/tendências , Adulto Jovem
6.
Epilepsy Behav ; 90: 228-232, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30573339

RESUMO

AIM: This paper investigates the reasons and extent of hospital emergency department (ED) attendance by people with epilepsy in Wave 4 of The Australian Longitudinal Survey 2016-17. METHOD: Wave 4 had 393 respondents who completed the survey, which included questions relating to their use of hospital and healthcare services. Of these, 121 (31%; 82 females) reported one or more admissions to the ED within the previous 12 months. We conducted a mixed methods analysis - using quantitative measures to explore the type and number of admissions, factors relating to increased admissions, and a qualitative approach to explore respondent experiences of their admissions. RESULTS: Over half of the admissions reported were seizure-related, including injuries occurring as a result of seizures. More than 15% of respondents had more than four ED visits during the preceding 12 months of the survey. Those who had experienced seizures within the previous 12 months, irrespective of frequency, were more likely to have attended the ED compared with those who had not experienced a recent seizure. Self-reported income was another major factor in ED use. Experiences of hospitalization demonstrated frustration at being taken to the ED, loss of autonomy, and experiences of inappropriate care due to poor understanding of epilepsy. Some respondents did not want to waste the ED time as they felt that a rest was all they needed following a seizure. DISCUSSION: The rates of hospitalization for seizure-related reasons are in line with the findings of other epilepsy-related studies, as is the increased hospitalization rate of those from less well-off backgrounds. This study provided a valuable picture of the opinions and attitudes of people with epilepsy towards their healthcare services. CONCLUSION: While this is an analysis of a small cohort, the consistency of reported experiences suggests that ED is not always felt to be appropriate following a seizure, and misunderstanding around the appropriate treatment of epilepsy continues in healthcare services.


Assuntos
Serviço Hospitalar de Emergência/tendências , Epilepsia/epidemiologia , Epilepsia/terapia , Ódio , Admissão do Paciente/tendências , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Austrália/epidemiologia , Criança , Estudos de Coortes , Epilepsia/psicologia , Feminino , Hospitalização/tendências , Hospitais/tendências , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Sistema de Registros , Autorrelato , Fatores de Tempo , Adulto Jovem
7.
Epilepsy Behav ; 100(Pt A): 106527, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31522077

RESUMO

AIM: This paper reports on contributing factors to Quality of Life (QoL) in an Australian community sample of people with epilepsy (PWE). METHOD: Three hundred and ninety-three respondents or 29.6% of people on the Australian Epilepsy Research Register participated in Wave 4 of a longitudinal survey. A quantitative analysis was undertaken and a qualitative investigation examined open-ended responses by 44 PWE on the support services that they received following diagnosis of epilepsy. RESULTS: Total Quality of Life in Epilepsy-31 Items (QOLIE-31) score for the community-based sample was 55.99 (SD 19.85) [Range 6.34-96.20]. Age, paid employment, seizure frequency, number of antiepileptic drugs (AEDs), and perceived prosperity had significant impacts on QoL. In addition, use of support services showed that availability of a first seizure clinic, accurate information on support services and peer support were associated with the highest QoL. A qualitative investigation revealed that on first diagnosis, a lack of information was the main theme. Furthermore, PWE reported a lack of understanding of available supports by a range of health professionals, schools, and in the general community. DISCUSSION: Psychosocial factors were important in explaining QoL, and the positive effects of first seizure clinics, accurate information on support services, and of peer support have been confirmed in the literature. The lack of knowledge of support services on being diagnosed with epilepsy is a problem evident in the community and pathways are required to support people dealing with their epilepsy. CONCLUSION: More emphasis is needed in providing availability of supports to enhance the future wellbeing and QoL of people when epilepsy is diagnosed.


Assuntos
Epilepsia/psicologia , Necessidades e Demandas de Serviços de Saúde , Qualidade de Vida , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Anticonvulsivantes/uso terapêutico , Austrália , Criança , Pré-Escolar , Emprego/psicologia , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Grupo Associado , Pesquisa Qualitativa , Qualidade de Vida/psicologia , Convulsões/tratamento farmacológico , Apoio Social , Fatores Socioeconômicos , Inquéritos e Questionários , Adulto Jovem
8.
Aust Fam Physician ; 46(3): 132-136, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28260276

RESUMO

BACKGROUND: Epilepsy is a common neurological disease with a high prevalence in people aged 65 years or older. Therefore, an understanding of the disease is important. The objective of this article was to determine older people's knowledge of epilepsy. METHODS: Electronic or paper-based surveys were completed by people aged 65 years and older. RESULTS: Five hundred and seventy-two surveys were completed, including 100 from people with epilepsy. Those with epilepsy had relatively poor knowledge of their condition, but they answered some questions significantly more correctly than participants without epilepsy. The main predictor of knowledge was clear information from a health professional. Two-thirds of those with epilepsy had their condition managed by a general practitioner. DISCUSSION: Older people with epilepsy need more information on their condition to facilitate better care management.


Assuntos
Epilepsia/prevenção & controle , Epilepsia/psicologia , Conhecimentos, Atitudes e Prática em Saúde , Educação de Pacientes como Assunto/métodos , Satisfação do Paciente/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Epilepsia/diagnóstico , Medicina de Família e Comunidade/organização & administração , Feminino , Humanos , Masculino , Inquéritos e Questionários
9.
Ecology ; 97(6): 1566-82, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27459786

RESUMO

Salvage logging following windthrow is common throughout forests worldwide even though the practice is often considered inimical to forest recovery. Because salvaging removes trees, crushes seedlings, and compacts soils, many warn this practice may delay succession, suppress diversity, and alter composition. Here, over 8 yr following windthrow, we experimentally evaluate how salvaging affects tree succession across 11 gaps in Eastern deciduous forests of Pennsylvania, wherein each gap was divided into salvaged and control (unsalvaged) halves. Our gaps vary in size and windthrow severity, and we explicitly account for this variation as well as variation in soil disturbance (i.e., scarification) resulting from salvaging so that our results would be generalizable. Salvage logging had modest and ephemeral impacts on tree succession. Seedling richness and density declined similarly over time in both salvaged and unsalvaged areas as individuals grew into saplings. The primary impact of salvaging on succession occurred where salvaging scarified soils. Here, salvaging caused 41 to 82% declines in sapling abundance, richness, and diversity, but these differences largely disappeared within 5 yr. Additionally, we documented interactions between windthrow severity and scarification. Specifically, low-severity windthrow and scarification combined reinforced dominance by shade-tolerant and browse-tolerant species (Acer pensylvanicum, Fagus grandifolia). In contrast, high windthrow severity and scarification together reduced the density of a fast-growing pioneer tree (Prunus pensylvanica) and non-tree vegetation cover by 75% and 26%, respectively. This reduction enhanced the recruitment of two mid-successional tree species, Acer rubrum and Prunus serotina, by 2 and 3-fold, respectively. Thus, our findings demonstrate that salvaging creates novel microsites and mitigates competing vegetation, thereby enhancing establishment of important hardwoods and promoting tree species coexistence. Our results, coupled with an assessment of 27 published post-windthrow salvage studies, suggest short-term studies may overestimate the impact of salvaging on regeneration. We conclude that the ecological costs and benefits of salvaging depend upon the variation in canopy and soil disturbance severity as well as the timescale at which effects are evaluated. Thus, our findings are inconsistent with the view that salvaging inexorably undermines plant diversity; rather we suggest salvaging can promote tree species coexistence within various contexts.


Assuntos
Conservação dos Recursos Naturais/métodos , Agricultura Florestal/métodos , Florestas , Atividades Humanas , Árvores/classificação , Monitoramento Ambiental , Especificidade da Espécie
10.
Oecologia ; 175(4): 1325-35, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24972697

RESUMO

The nucleation hypothesis appears to explain widespread patterns of succession in tropical pastures, specifically the tendency for isolated trees to promote woody species recruitment. Still, the nucleation hypothesis has usually been tested explicitly for only short durations and in some cases isolated trees fail to promote woody recruitment. Moreover, at times, nucleation occurs in other key habitat patches. Thus, we propose an extension, the matrix discontinuity hypothesis: woody colonization will occur in focal patches that function to mitigate the herbaceous vegetation effects, thus providing safe sites or regeneration niches. We tested predictions of the classical nucleation hypothesis, the matrix discontinuity hypothesis, and a distance from forest edge hypothesis, in five abandoned pastures in Costa Rica, across the first 11 years of succession. Our findings confirmed the matrix discontinuity hypothesis: specifically, rotting logs and steep slopes significantly enhanced woody colonization. Surprisingly, isolated trees did not consistently significantly enhance recruitment; only larger trees did so. Finally, woody recruitment consistently decreased with distance from forest. Our results as well as results from others suggest that the nucleation hypothesis needs to be broadened beyond its historical focus on isolated trees or patches; the matrix discontinuity hypothesis focuses attention on a suite of key patch types or microsites that promote woody species recruitment. We argue that any habitat discontinuities that ameliorate the inhibition by dense graminoid layers will be foci for recruitment. Such patches could easily be manipulated to speed the transition of pastures to closed canopy forests.


Assuntos
Conservação dos Recursos Naturais , Ecossistema , Clima Tropical , Costa Rica
11.
Clin Adv Hematol Oncol ; 12(8): 509-15, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-25356575

RESUMO

INTRODUCTION: Yttrium 90-ibritumomab tiuxetan (90Y-IT) radioimmunotherapy has proved to be effective in relapsed follicular lymphoma (FL). We conducted a clinical trial in which 90Y-IT followed by maintenance rituximab (MR) was evaluated as initial therapy for high-tumor-burden FL. METHODS: Eligible patients had histologically confirmed FL and met the GELF (Groupe d'Etude des Lymphomes Folliculaires) criteria for high tumor burden. All patients received a single dose of 90Y-IT. Patients with platelet counts of 150,000/mm³ or higher received 0.4 mCi/kg, and patients with platelet counts between 100,000/mm³ and 149,000/mm³ received 0.3 mCi/kg. At 6 months, patients without progressive disease (PD) received rituximab weekly for 4 weeks at a dose of 375 mg/m² (consolidation therapy), followed by MR consisting of the same dose every 3 months for a planned 5 years. RESULTS: From January 2005 through November 2007, a total of 16 patients were enrolled. The median age was 52 years (range, 37-75). The major toxicity from 90Y-IT was myelosuppression, with 88% and 31% of the patients experiencing grade 3 and grade 4 hematologic toxicity, respectively. The responses to 90Y-IT induction therapy were as follows: 7 patients with complete response/unconfirmed complete response (CR/Cru), 4 with partial response (PR), 3 with stable disease (SD), and 2 with progressive disease (PD). We identified 6 patients with early PD (range, 4-16 months) and 10 patients with prolonged remission (range, 37-101+ months). Compared with the patients who had prolonged remission, the patients who had early PD tended to have larger baseline nodal masses. The median progression-free survival (PFS) has not been reached after a median follow-up period of 48 months. The 3-year PFS and overall survival (OS) rates were 56% (95% CI, 37%-87%) and 93% (95% CI, 80%-100%), respectively. CONCLUSION: The overall response rate (ORR) to 90Y-IT was 69% in patients who had previously untreated, high-tumor-burden FL, which is lower than what is observed with contemporary rituximab/chemotherapy combinations. MR after 90Y-IT did convert all PRs to CRs. Alternative therapies should be considered for patients who have FL with large nodal masses (>9 cm), whereas very durable responses are possible in patients who have intermediate-size masses (>9 cm).


Assuntos
Anticorpos Monoclonais Murinos/uso terapêutico , Anticorpos Monoclonais/uso terapêutico , Antineoplásicos/uso terapêutico , Linfoma Folicular/patologia , Linfoma Folicular/terapia , Radioimunoterapia , Radioisótopos de Ítrio/uso terapêutico , Adulto , Idoso , Anticorpos Monoclonais/administração & dosagem , Anticorpos Monoclonais/efeitos adversos , Anticorpos Monoclonais Murinos/administração & dosagem , Anticorpos Monoclonais Murinos/efeitos adversos , Antineoplásicos/administração & dosagem , Antineoplásicos/efeitos adversos , Esquema de Medicação , Feminino , Humanos , Linfoma Folicular/diagnóstico , Linfoma Folicular/mortalidade , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Estudos Prospectivos , Rituximab , Resultado do Tratamento , Carga Tumoral , Wisconsin , Radioisótopos de Ítrio/administração & dosagem , Radioisótopos de Ítrio/efeitos adversos
12.
J Eval Clin Pract ; 2024 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-38975616

RESUMO

BACKGROUND: The extent to which governments provide socioeconomic supports has been highlighted by their spending during the COVID-19 pandemic. This has implications for patterns of inequality, in particular on exacerbating unequal health and well-being. RESULTS: Inequity has expanded due to neoliberalism, a market-based approach that has endured for more than four decades. Together with COVID-19, it has developed and exposed many structural governance differences. DISCUSSION: There are a number of examples presented of the effects of inequalities on health and well-being. The role of general practice in addressing these is discussed and challenges are highlighted, especially those relating to payment systems and workforce constraints.

13.
Arthroscopy ; 29(1): 122-32, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23200845

RESUMO

PURPOSE: The objective of this study was to assess the effect of absorbable or nonabsorbable sutures in bioenhanced anterior cruciate ligament (ACL) repair in a skeletally immature pig model on suture tunnel and growth plate healing and biomechanical outcomes. METHODS: Sixteen female skeletally immature Yorkshire pigs were randomly allocated to receive unilateral, bioenhanced ACL repair with an absorbable (Vicryl) or nonabsorbable (Ethibond) suture augmented by an extracellular matrix-based scaffold (MIACH). After 15 weeks of healing, micro-computed tomography was used to measure residual tunnel diameters and growth plate status, and biomechanical outcomes were assessed. RESULTS: At 15 weeks postoperatively, there was a significant difference in tunnel diameter with significantly larger diameters in the nonabsorbable suture group (4.4 ± 0.3 mm; mean ± SD) than in the absorbable group (1.8 ± 0.5 mm; P < .001). The growth plate showed a significantly greater affected area in the nonabsorbable group (15.2 ± 3.4 mm(2)) than in the absorbable group (2.7 ± 0.8 mm(2), P < .001). There was no significant difference in the linear stiffness of the repairs (29.0 ± 14.8 N/mm for absorbable v 43.3 ± 28.3 N/mm for nonabsorbable sutures, P = .531), but load to failure was higher in the nonabsorbable suture group (211 ± 121.5 N) than in the absorbable suture group (173 ± 101.4 N, P = .002). There was no difference between the 2 groups in anteroposterior laxity at 30° (P = .5117), 60° (P = .3150), and 90° (P = .4297) of knee flexion. CONCLUSIONS: The use of absorbable sutures for ACL repair resulted in decreased physeal plate damage after 15 weeks of healing; however, use of nonabsorbable sutures resulted in 20% stronger repairs. CLINICAL RELEVANCE: Choice of suture type for ACL repair or repair of tibial avulsion fractures may depend on patient skeletal age and size, with absorbable sutures preferred in very young, small patients at higher risk with physeal damage and nonabsorbable sutures preferred in larger, prepubescent patients who may place higher loads on the repair.


Assuntos
Reconstrução do Ligamento Cruzado Anterior/métodos , Lâmina de Crescimento/fisiopatologia , Polietilenotereftalatos , Poliglactina 910 , Suturas , Alicerces Teciduais , Cicatrização , Implantes Absorvíveis , Fatores Etários , Animais , Fenômenos Biomecânicos , Sangue , Densidade Óssea , Colágeno , Falha de Equipamento , Feminino , Fêmur/diagnóstico por imagem , Fêmur/fisiopatologia , Fêmur/cirurgia , Lâmina de Crescimento/química , Lâmina de Crescimento/diagnóstico por imagem , Lâmina de Crescimento/cirurgia , Instabilidade Articular/etiologia , Teste de Materiais , Complicações Pós-Operatórias/etiologia , Radiografia , Distribuição Aleatória , Sus scrofa/crescimento & desenvolvimento , Suínos , Resistência à Tração , Tíbia/diagnóstico por imagem , Tíbia/fisiopatologia , Tíbia/cirurgia , Suporte de Carga
14.
Front Artif Intell ; 6: 1274830, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38075384

RESUMO

We propose the geometric framework of the Schubert variety as a tool for representing a collection of subspaces of a fixed vector space. Specifically, given a collection of l-dimensional subspaces V1, …, Vr of ℝn, represented as the column spaces of matrices X1, …, Xr, we seek to determine a representative matrix K∈ℝn×k such that each subspace Vi intersects (or comes close to intersecting) the span of the columns of K in at least c dimensions. We formulate a non-convex optimization problem to determine such a K along with associated sets of vectors {ai} and {bi} used to express linear combinations of the columns of the Xi that are close to linear combinations of the columns of K. Further, we present a mechanism for integrating this representation into an artificial neural network architecture as a computational unit (which we refer to as an abstract node). The representative matrix K can be learned in situ, or sequentially, as part of a learning problem. Additionally, the matrix K can be employed as a change of coordinates in the learning problem. The set of all l-dimensional subspaces of ℝn that intersects the span of the columns of K in at least c dimensions is an example of a Schubert subvariety of the Grassmannian GR(l, n). When it is not possible to find a Schubert variety passing through a collection of points on GR(l, n), the goal of the non-convex optimization problem is to find the Schubert variety of best fit, i.e., the Schubert variety that comes as close as possible to the points. This may be viewed as an analog of finding a subspace of best fit to data in a vector space. The approach we take is well-suited to the modeling of collections of sets of data either as a stand-alone Schubert variety of best fit (SVBF), or in the processing workflow of a deep neural network. We present applications to some classification problems on sets of data to illustrate the behavior of the method.

15.
Front Artif Intell ; 6: 1255192, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38075385

RESUMO

A ReLU neural network functions as a continuous piecewise linear map from an input space to an output space. The weights in the neural network determine a partitioning of the input space into convex polytopes, where each polytope is associated with a distinct affine mapping. The structure of this partitioning, together with the affine map attached to each polytope, can be analyzed to investigate the behavior of the associated neural network. We investigate simple problems to build intuition on how these regions act and both how they can potentially be reduced in number and how similar structures occur across different networks. To validate these intuitions, we apply them to networks trained on MNIST to demonstrate similarity between those networks and the potential for them to be reduced in complexity.

16.
J Eval Clin Pract ; 28(2): 338-340, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-34647671

RESUMO

Sturmberg and Martin's application of systems and complexity theory to understanding Universal Health Care (UHC) and Primary Health Care (PHC) is evaluated in the light of the influence of political economy on health systems. Furthermore, the role that neoliberal approaches to governance have had in creating increased inequities is seen as a key challenge for UHC. COVID-19 has emphasized long standing discrepancies in health and these disadvantages require government will and cooperation together with adequate social services to redress these discrepancies in UHC.


Assuntos
COVID-19 , Assistência de Saúde Universal , COVID-19/epidemiologia , Humanos , Cobertura Universal do Seguro de Saúde
17.
J Eval Clin Pract ; 27(5): 1027-1032, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-33189085

RESUMO

Sturmberg and Martin in 2020 argue that universal health coverage (UHC) is mainly about financing, and primary health care (PHC) is about the right care at the right time to ensure health. They maintain that the World Health Organization has recently sent the wrong message about the "pillars" of PHC in their relationship to UHC. An understanding of political economy is required in order to come to terms with the bases of PHC and the fundamentals of UHC that dealing with inequities is not only an economic issue but fundamentally a political issue. Neoliberal decision-making can enhance inequities in society. Two chronic health conditions, diabetes and multiple sclerosis, are examples of conditions that lead to costly and debilitating consequences for patients but also lead to substantial economic costs in terms of lost workforce participation and lost productivity. These cases demonstrate the socio-political issues involved in the management of care for a number of illnesses. The upsurge of COVID-19 has placed an enormous strain on health and broader social and economic resources and challenged the pretext of UHC as health for all: substantial differences in equity and political commitment have emerged. Sturmberg and Martin argue that the joining of UHC and PHC needs leadership, which involves local communities and resourcing. PHC is a changing system based on power relationships involving funders and the health community. In Australia as in several countries, out-of-pocket costs have grown rapidly and have affected access for some groups to PHC and have challenged the pretext of equity in UHC. In the context of PHC and UHC, we support the position that health for all goes beyond health care for all, to embrace healthy lives promoting wellbeing.


Assuntos
COVID-19 , Cobertura Universal do Seguro de Saúde , Gastos em Saúde , Humanos , Atenção Primária à Saúde , SARS-CoV-2
18.
J Econ Entomol ; 103(2): 433-6, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-20429459

RESUMO

The initial soil penetration of Premise 75 and Termidor SC, containing imidacloprid and fipronil, respectively, were tested in laboratory columns of five different soils. Three combinations of application concentration and volume were used: double the recommended active ingredient concentration at one half the recommended volume (DR), the full concentration and volume (FR), and one half the concentration and twice the volume (HR). In all three cases, the same total amount of active ingredient (0.01 g of imidacloprid for Premise and 0.012 g of fipronil for Termidor) was applied to the same soil surface area (45.36 cm2). Regardless of soil or application method, the concentration of active ingredient was highest in the top 1 cm of soil. Within each soil, the concentration in the top 1 cm was highest in the DR treatment and lowest in the HR treatment. At each depth below 1 cm, active ingredient concentration was highest in the HR treatment and lowest in the DR treatment. The DR treatment therefore results in a thinner barrier of higher initial concentration in the top 1 cm, whereas the HR treatment results in a thicker barrier but of lower initial concentration in the top 1 cm.


Assuntos
Imidazóis/farmacologia , Inseticidas/farmacologia , Isópteros/efeitos dos fármacos , Nitrocompostos/farmacologia , Pirazóis/farmacologia , Solo , Animais , Imidazóis/administração & dosagem , Controle de Insetos/métodos , Inseticidas/administração & dosagem , Neonicotinoides , Nitrocompostos/administração & dosagem , Pirazóis/administração & dosagem
19.
Int J Health Serv ; 40(4): 609-27, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21058534

RESUMO

The new millennium has seen the projected growth of older populations as a source of many problems, not the least of which is how to sustain this increasingly aging population. Some decades ago, early retirement from work posed few problems for governments, but most nations are now trying to ensure that workers remain in the workforce longer. In this context, the role played by older employees can be affected by at least two factors: their productivity (or perceived productivity) and their acceptance by younger workers and management. If the goal of maintaining employees into older age is to be achieved and sustained, opportunities must be provided, for example, for more flexible work arrangements and more possibilities to pursue bridge employment (work after formal retirement). The retirement experience varies, depending on people's circumstances. Some people, for example, have retirement forced upon them by illness or injury at work, by ill-health (such as chronic illnesses), or by downsizing and associated redundancies. This article focuses on the problems and opportunities associated with working to an older age or leaving the workforce early, particularly due to factors beyond one's control.


Assuntos
Emprego/tendências , Aposentadoria/tendências , Fatores Etários , Idoso , Eficiência , Europa (Continente) , Humanos , Relação entre Gerações , Pensões , Admissão e Escalonamento de Pessoal/tendências , Dinâmica Populacional , Política Pública , Estados Unidos
20.
IEEE Trans Pattern Anal Mach Intell ; 31(2): 351-63, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19110498

RESUMO

The theory of illumination subspaces is well developed and has been tested extensively on the Yale Face Database B (YDB) and CMU-PIE (PIE) data sets. This paper shows that if face recognition under varying illumination is cast as a problem of matching sets of images to sets of images, then the minimal principal angle between subspaces is sufficient to perfectly separate matching pairs of image sets from nonmatching pairs of image sets sampled from YDB and PIE. This is true even for subspaces estimated from as few as six images and when one of the subspaces is estimated from as few as three images if the second subspace is estimated from a larger set (10 or more). This suggests that variation under illumination may be thought of as useful discriminating information rather than unwanted noise.


Assuntos
Algoritmos , Inteligência Artificial , Face/anatomia & histologia , Interpretação de Imagem Assistida por Computador/métodos , Imageamento Tridimensional/métodos , Iluminação/métodos , Reconhecimento Automatizado de Padrão/métodos , Humanos , Aumento da Imagem/métodos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Técnica de Subtração
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