RESUMO
A series of 3,6-bis(aminoalkoxy)acridines (2) was prepared and shown to have a protective antiviral effect against an interferon-sensitive virus (Columbia SK) and to partially restore an antibody response to a T-cell-dependent antigen in leukemic immunosuppressed mice. The presence of circulating interferon and the stimulation of natural killer cell activity in mice was observed for 21.
Assuntos
Acridinas/síntese química , Formação de Anticorpos/efeitos dos fármacos , Acridinas/farmacologia , Animais , Antivirais/síntese química , Antivirais/farmacologia , Terapia de Imunossupressão , Células Matadoras Naturais/efeitos dos fármacos , Células Matadoras Naturais/imunologia , CamundongosRESUMO
Two field trials using an injectable vitamin A, D and E solution conducted in the pastoral environment of northern Australia are described. It was found that treatment of lighter (< 150 kg) or heavier (> 372 kg) weight cattle did not reduce weight loss during road transport. These findings contradict anecdotal evidence of reduced weight loss during transport with the use of vitamins A, D and E. The lack of scientific basis for their use is discussed.