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Turk J Med Sci ; 51(3): 1033-1042, 2021 06 28.
Artigo em Inglês | MEDLINE | ID: mdl-33315343

RESUMO

Background/aim: The aim of this study is to assess the efficacy and safety of ruxolitinib in patients with myelofibrosis. Materials and methods: From 15 centers, 176 patients (53.4% male, 46.6% female) were retrospectively evaluated. Results: The median age at ruxolitinib initiation was 62 (28­87) and 100 (56.8%) of all were diagnosed as PMF. Constitutional symptoms were observed in 84.7%. The median initiation dose of ruxolitinib was 30 mg (10­40). Dose change was made in 69 (39.2%) patients. Forty seven (35.6%) and 20 (15.2%) of 132 patients had hematological and nonhematological adverse events, respectively. The mean spleen sizes before and after ruxolitinib treatment were 219.67 ± 46.79 mm versus 199.49 ± 40.95 mm, respectively (p < 0.001). There was no correlation between baseline features and subsequent spleen response. Overall survival at 1-year was 89.5% and the median follow up was 10 (1­55) months. We could not show any relationship between survival and reduction in spleen size (p = 0.73). Conclusion: We found ruxolitinib to be safe, well tolerated, and effective in real-life clinical practice in Turkey. Ruxolitinib dose titration can provide better responses in terms of not only clinical benefit but also for long term of ruxolitinib treatment.


Assuntos
Nitrilas/uso terapêutico , Mielofibrose Primária , Pirazóis/uso terapêutico , Pirimidinas/uso terapêutico , Feminino , Humanos , Masculino , Mielofibrose Primária/tratamento farmacológico , Mielofibrose Primária/epidemiologia , Pirazóis/efeitos adversos , Estudos Retrospectivos , Turquia/epidemiologia
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