Detalhe da pesquisa
1.
Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication.
Proc Natl Acad Sci U S A
; 118(49)2021 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34845015
2.
The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2.
J Virol
; 94(23)2020 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32938769
3.
Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors.
J Virol
; 93(18)2019 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31243130
4.
Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses.
Nucleic Acids Res
; 43(17): 8416-34, 2015 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26304538
5.
One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities.
Proc Natl Acad Sci U S A
; 111(37): E3900-9, 2014 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25197083
6.
Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.
Nucleic Acids Res
; 42(5): 3464-77, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24369429
7.
Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.
J Biol Chem
; 289(37): 25783-96, 2014 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25074927
8.
Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins.
J Gen Virol
; 96(9): 2643-2655, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26041874
9.
Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.
Bioorg Med Chem Lett
; 25(15): 2923-6, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048809
10.
Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.
Antimicrob Agents Chemother
; 58(8): 4875-84, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24841269
11.
MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment.
J Gen Virol
; 94(Pt 8): 1749-1760, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23620378
12.
Structure and genetic analysis of the arterivirus nonstructural protein 7alpha.
J Virol
; 85(14): 7449-53, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21561912
13.
Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production.
J Gen Virol
; 92(Pt 5): 1097-1106, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21307223
14.
The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle.
J Virol
; 84(15): 7869-79, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20484504
15.
Formation of the arterivirus replication/transcription complex: a key role for nonstructural protein 3 in the remodeling of intracellular membranes.
J Virol
; 82(9): 4480-91, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18305048
16.
The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity.
Front Microbiol
; 10: 1813, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31440227
17.
Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues.
J Med Chem
; 62(13): 6346-6362, 2019 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31244113
18.
Cyclophilins and cyclophilin inhibitors in nidovirus replication.
Virology
; 522: 46-55, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30014857
19.
Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture.
Virology
; 517: 148-156, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29249267
20.
Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes.
Virus Res
; 234: 58-73, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28174054