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PLoS Negl Trop Dis ; 18(3): e0012022, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38484041

RESUMO

Pacific Island countries have experienced periodic dengue, chikungunya and Zika outbreaks for decades. The prevention and control of these mosquito-borne diseases rely heavily on control of Aedes aegypti mosquitoes, which in most settings are the primary vector. Introgression of the intracellular bacterium Wolbachia pipientis (wMel strain) into Ae. aegypti populations reduces their vector competence and consequently lowers dengue incidence in the human population. Here we describe successful area-wide deployments of wMel-infected Ae. aegypti in Suva, Lautoka, Nadi (Fiji), Port Vila (Vanuatu) and South Tarawa (Kiribati). With community support, weekly releases of wMel-infected Ae. aegypti mosquitoes for between 2 to 5 months resulted in wMel introgression in nearly all locations. Long term monitoring confirmed a high, self-sustaining prevalence of wMel infecting mosquitoes in almost all deployment areas. Measurement of public health outcomes were disrupted by the Covid19 pandemic but are expected to emerge in the coming years.


Assuntos
Aedes , Vírus da Dengue , Dengue , Wolbachia , Infecção por Zika virus , Zika virus , Animais , Humanos , Aedes/genética , Aedes/microbiologia , Mosquitos Vetores/genética , Mosquitos Vetores/microbiologia , Wolbachia/genética , Fiji/epidemiologia , Vanuatu
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