Detalhe da pesquisa
1.
Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration.
Hum Mol Genet
; 32(2): 204-217, 2023 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35943778
2.
Understanding metabolism related differences in ocular efficacy of MGV354.
Xenobiotica
; 51(1): 5-14, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32662714
3.
Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells.
J Biol Chem
; 293(52): 20137-20156, 2018 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30389787
4.
Glaucoma - Next Generation Therapeutics: Impossible to Possible.
Pharm Res
; 36(2): 25, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30547244
5.
Endothelin, astrocytes and glaucoma.
Exp Eye Res
; 93(2): 170-7, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20849847
6.
Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma.
Exp Eye Res
; 93(3): 256-64, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21376717
7.
Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin F2α agonist, in preclinical models.
Exp Eye Res
; 93(3): 250-5, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21396362
8.
Application of Cell Impedance as a Screening Tool to Discover Modulators of Intraocular Pressure.
J Ocul Pharmacol Ther
; 36(5): 269-281, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32176566
9.
Pharmacokinetic-pharmacodynamic and response sensitization modeling of the intraocular pressure-lowering effect of the EP4 Agonist 5-{3-[(2S)-2-{(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]butyl}-5-oxopyrrolidin-1-yl]propyl}thiophene-2-carboxylate (PF-04475270).
J Pharmacol Exp Ther
; 331(2): 627-35, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19690190
10.
Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models.
Exp Eye Res
; 89(5): 608-17, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19445930
11.
Synthesis of novel nitric oxide (NO)-releasing esters of timolol.
Bioorg Med Chem Lett
; 19(10): 2785-8, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19361986
12.
Corneal neovascularization and ocular irritancy responses in dogs following topical ocular administration of an EP4-prostaglandin E2 agonist.
Toxicol Pathol
; 37(7): 911-20, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20008547
13.
L-Carnosine: multifunctional dipeptide buffer for sustained-duration topical ophthalmic formulations.
J Pharm Pharmacol
; 61(6): 733-42, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19505363
14.
Using Healthcare Databases to Refine Understanding of Exploratory Associations Between Drugs and Progression of Open-Angle Glaucoma.
Clin Pharmacol Ther
; 106(4): 874-883, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31038730
15.
Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle.
PLoS One
; 13(11): e0206801, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30395621
16.
A murine glaucoma model induced by rapid in vivo photopolymerization of hyaluronic acid glycidyl methacrylate.
PLoS One
; 13(6): e0196529, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29949582
17.
A Novel Selective Soluble Guanylate Cyclase Activator, MGV354, Lowers Intraocular Pressure in Preclinical Models, Following Topical Ocular Dosing.
Invest Ophthalmol Vis Sci
; 59(5): 1704-1716, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29610853
18.
A Randomized, Controlled Phase I/II Study to Evaluate the Safety and Efficacy of MGV354 for Ocular Hypertension or Glaucoma.
Am J Ophthalmol
; 192: 113-123, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29802818
19.
The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma.
J Med Chem
; 61(6): 2552-2570, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29498522
20.
Endothelin-1-mediated signaling in the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in astrocytes.
Invest Ophthalmol Vis Sci
; 48(8): 3737-45, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17652746