Detalhe da pesquisa
1.
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.
Cell
; 140(2): 209-21, 2010 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20141835
2.
Ex vivo explant model of adenoma and colorectal cancer to explore mechanisms of action and patient response to cancer prevention therapies.
Mutagenesis
; 37(5-6): 227-237, 2022 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36426854
3.
Ras/MAPK dysregulation in development causes a skeletal myopathy in an activating BrafL597V mouse model for cardio-facio-cutaneous syndrome.
Dev Dyn
; 250(8): 1074-1095, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33522658
4.
Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants.
Lab Invest
; 101(3): 396-407, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33318618
5.
Development of a patient-derived explant model for prediction of drug responses in endometrial cancer.
Gynecol Oncol
; 160(2): 557-567, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33309417
6.
Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery.
Br J Cancer
; 122(6): 735-744, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31894140
7.
Exploration of Matrix Effects in Laser Ablation Inductively Coupled Plasma Mass Spectrometry Imaging of Cisplatin-Treated Tumors.
Anal Chem
; 92(14): 9847-9855, 2020 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32545955
8.
Patient-derived explants, xenografts and organoids: 3-dimensional patient-relevant pre-clinical models in endometrial cancer.
Gynecol Oncol
; 156(1): 251-259, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31767187
9.
The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.
Genes Dev
; 26(17): 1945-58, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22892241
10.
KRASG12D expression in lung-resident myeloid cells promotes pulmonary LCH-like neoplasm sensitive to statin treatment.
Blood
; 130(4): 514-526, 2017 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28550040
11.
Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development.
J Biol Chem
; 292(8): 3164-3171, 2017 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28073913
12.
CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation.
Mol Cell
; 31(6): 862-72, 2008 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-18922468
13.
KRAS(G12D)-mediated oncogenic transformation of thyroid follicular cells requires long-term TSH stimulation and is regulated by SPRY1.
Lab Invest
; 95(11): 1269-77, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26146959
14.
Cdx2 determines the fate of postnatal intestinal endoderm.
Development
; 139(3): 465-74, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22190642
15.
Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels.
Mol Pharmacol
; 86(2): 211-21, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24830940
16.
Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.
Proc Natl Acad Sci U S A
; 108(4): 1615-20, 2011 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21220306
17.
An optimised patient-derived explant platform for breast cancer reflects clinical responses to chemotherapy and antibody-directed therapy.
Sci Rep
; 14(1): 12833, 2024 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38834809
18.
Precision medicines for B-cell leukaemias and lymphomas; progress and potential pitfalls.
Br J Haematol
; 160(6): 725-33, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23346939
19.
RalGDS is required for tumor formation in a model of skin carcinogenesis.
Cancer Cell
; 7(3): 219-26, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15766660
20.
BRAFV600E-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism.
Commun Biol
; 6(1): 962, 2023 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37735514