Detalhe da pesquisa
1.
In vitro assessment of farnesoid X receptor antagonism to predict drug-induced liver injury risk.
Arch Toxicol
; 94(9): 3185-3200, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32583097
2.
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury.
Arch Toxicol
; 91(8): 2849-2863, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28612260
3.
Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment.
Hepatology
; 62(2): 546-57, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25712247
4.
Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers.
J Pharmacol Exp Ther
; 352(3): 519-28, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25563903
5.
Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice.
Hepatology
; 60(5): 1741-52, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24723460
6.
Eosinophils mediate the pathogenesis of halothane-induced liver injury in mice.
Hepatology
; 57(5): 2026-36, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23238640
7.
Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase.
Proc Natl Acad Sci U S A
; 108(16): 6650-5, 2011 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21464302
8.
Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes.
Mol Pharmacol
; 84(2): 182-9, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23680637
9.
Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites.
Drug Metab Dispos
; 41(6): 1179-86, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23482500
10.
Cigarette smoke exposure greatly increases alcohol consumption in adolescent C57BL/6 mice.
Alcohol Clin Exp Res
; 37 Suppl 1: E364-72, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22827559
11.
Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice.
Chem Res Toxicol
; 25(1): 83-93, 2012 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22107450
12.
Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate).
ALTEX
; 39(2): 297314, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35064273
13.
Functional adaptation of the N-methyl-D-aspartate receptor to inhibition by ethanol is modulated by striatal-enriched protein tyrosine phosphatase and p38 mitogen-activated protein kinase.
Mol Pharmacol
; 80(3): 529-37, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21680777
14.
3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration.
Clin Transl Sci
; 14(5): 1659-1680, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33982436
15.
Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption.
J Neurochem
; 115(5): 1112-22, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20831600
16.
Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia.
J Child Psychol Psychiatry
; 51(5): 535-49, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19925602
17.
Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications.
Lab Chip
; 20(6): 1049-1057, 2020 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32073020
18.
Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry.
Lab Chip
; 20(2): 215-225, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31799979
19.
Variance component analysis of circulating miR-122 in serum from healthy human volunteers.
PLoS One
; 14(7): e0220406, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31348817
20.
Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.
J Med Chem
; 62(8): 4091-4109, 2019 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30943032