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1.
J Environ Manage ; 370: 122543, 2024 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-39305881

RESUMO

Soil pollution by microplastics (MPs) is an escalating environmental crisis with far-reaching consequences. However, current research on the degradation and/or remediation of MPs has mainly focused on water-simulated environments, with little attention given to soil MPs. Therefore, the review explores such terrestrial territory, exploring the potential of biodegradation and novel photocatalytic technologies for MPs degradation/remediation in soil. This review comprehensively investigates the potential of biological and photocatalytic approaches for soil MPs degradation and remediation. A temporal analysis of research from 2004 to 2024 highlights the increasing focus on this critical issue. The review explores the biocatalytic roles of diverse enzymes, including cutinase, PETase, MHETase, hydrolase, lipase, laccase, lignin peroxidase, and Mn-peroxidase, in MPs degradation. Strategies for enzyme engineering, such as protein engineering and immobilization, are explored to enhance catalytic efficiency. The potential for developing enzyme consortia for optimized MP degradation is also discussed. Photocatalytic remediation using TiO2, ZnO, clay, hydrogel, and other photocatalysts is examined, emphasizing their mechanisms and effectiveness. Computational modeling is proposed to deepen understanding of soil MPs-catalyst interactions, primarily aiming to develop novel catalysts tailored for soil environments for environmental safety and sustainable restoration. A comparative analysis of biological and photocatalytic approaches evaluates their environmental implications and the potential for synergistic combinations, with emphasis on soil quality protection, restoration and impact on soil ecosystems. Hence, this review accentuates the urgent need for innovative solutions to address MPs pollution in soil and provides a foundational understanding of the current knowledge gaps, as well as paves the way for future research and development.

2.
S D Med ; 77(5): 200-204, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-39012772

RESUMO

INTRODUCTION: Hemodialysis (HD) patients experience significant psychological stress related to HD. Different types of coping strategies are utilized by these patients to cope with this stress. METHODS: Variations in different types of coping strategies with the variations in HD-related stress scores and disparities by sex were assessed. HD patients aged 18 years and above who were seeking regular treatment in a specific HD-unit of a hospital in the upper Midwest, were surveyed between March 2020 and July 2020. RESULTS: Descriptive statistics, correlational analyses, and regression analyses were performed. Females could be expected to have emotional coping scores 8 units greater than males, as B = 8.017 for sex in the model, p =.000. Females could be expected to have coping scores 6.4 points higher than males when adjusted for stress levels, as: B= 6.351, p =0.001 for sex in the model. For each 1 point increase in Stress Score, the Coping Score could be expected to: increase 6.8 points when adjusted for sex, where B = 6.751 and p =0.000. CONCLUSION: Increased prevalence of emotional pre-occupation was only observed among female patients which increased with the increase in stress. Psychological interventions in female HD patients should be strongly considered in addressing emotional pre-occupation coping.


Assuntos
Adaptação Psicológica , Diálise Renal , Estresse Psicológico , Humanos , Diálise Renal/psicologia , Feminino , Masculino , Estresse Psicológico/psicologia , Pessoa de Meia-Idade , Adulto , Fatores Sexuais , Idoso , Emoções , Falência Renal Crônica/terapia , Falência Renal Crônica/psicologia , Inquéritos e Questionários
3.
Neurosurg Rev ; 46(1): 57, 2023 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-36786867

RESUMO

Central neurocytoma is the most common primary intraventricular tumor in adults being classified by the World Health Organization (WHO) as a benign grade II tumor with a good prognosis. Given the recent advances with regard to this tumor, a bibliometric analysis was due to study the future direction of research for neurocytomas. A comprehensive Elsevier's Scopus database search was performed to capture all published and indexed studies to date relevant to neurocytoma. A discrete set of validated bibliometric parameters were extracted and analyzed on R v4.1.3. A total of 1002 documents were included in our analysis covering a period between 1910 and 2021 (111 years). Around 98.5% of the documents were multi-author publications with a collaboration index (CI) of 4.21. Acta Neuropathologica, The American Journal of Surgical Pathology, and Cancer were the journals to include the highest number of top ten cited articles (2 out of 10 most cited articles, 20%). Switzerland (4 out of 10, 40%) accounted for the country to have the highest number of top 10 most cited articles with the USA (5588 out of 16,395 citations, 34.1%) having the greatest number of citations. Lastly, our analysis reported an annual growth rate of 6.9% for the number of papers produced by year. This is the first bibliometric analysis to study the top 10 most cited articles with regard to neurocytomas. A shift from histopathologic and clinical symptoms towards the treatment and management of the tumor was observed in our analysis.


Assuntos
Neurocitoma , Humanos , Estados Unidos , Neurocitoma/cirurgia , Bibliometria , Publicações , Suíça , Bases de Dados Factuais
4.
S D Med ; 76(3): 102-110, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36898195

RESUMO

There is wide geographic variability in the prevalence of chronic kidney disease, and much of this variability is unexplained by known clinical risk determinants such as diabetes and hypertension. Additional factors contributing to this geographic variability include social determinants of kidney health, as well as genetic factors (ancestry) and non-genetic factors (the environment). Environmental nephrotoxins can accelerate the progression of kidney disease in some patients at risk. Examples of environmental nephrotoxins that have previously been associated with changes in glomerular filtration rate include chlorotriazine herbicides (e.g., atrazine) and trace metals (e.g., arsenic, cadmium, lead, and mercury). Land management practices influence the concentration of these nephrotoxins in our soil and water. In this review, we explore sustainable approaches to agriculture and the preservation of natural landscapes as land management practices that can optimize kidney health in a variety of communities.


Assuntos
Arsênio , Mercúrio , Humanos , Conservação dos Recursos Naturais , Rim , Cádmio
5.
S D Med ; 76(12): 553-560, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38986121

RESUMO

INTRODUCTION: Immunosuppressed patients are at an increased risk of complications from COVID-19. Despite the morbidity and mortality associated with COVID-19, there is little information regarding its effect on post-renal transplant patients. This study investigated the impact of a COVID-19 diagnosis on renal transplant recipients in terms of graft failure and mortality. METHODS: Renal transplant recipients were included if they had a functioning graft between March 2020 and March 2022. COVID-19 test results, duration from COVID-19 to graft failure and mortality, vaccination status, and COVID-19 treatment regimen were recorded and analyzed. RESULTS: There were 175 renal transplant recipients who met study criteria. Of these, 82 patients had documented COVID-19 cases, and 93 patients did not have a documented case. Of the patients who had a COVID-19 positive test, 3 experienced renal graft failure, and 15 experienced mortality. When comparing graft failure rate between the two groups, there was no significant difference. The mortality risk was significantly increased in COVID-19 positive patients (p=0.021). The COVID-19 immunization rate (at least one dose) was 82.5% for renal transplant recipients compared to 77.2% for all of South Dakota. CONCLUSIONS: There was no significant difference in renal graft failure rate between the two groups, but there was a significantly increased mortality risk in patients with COVID-19 positivity.


Assuntos
COVID-19 , Transplante de Rim , Humanos , COVID-19/epidemiologia , COVID-19/mortalidade , Masculino , Feminino , Estudos Retrospectivos , Pessoa de Meia-Idade , Adulto , Rejeição de Enxerto/prevenção & controle , Rejeição de Enxerto/epidemiologia , SARS-CoV-2 , Idoso , South Dakota/epidemiologia
6.
Chem Rec ; 22(7): e202100299, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35119182

RESUMO

Despite the photocatalytic organic pollutant degradation using ZnO started in 1910-1911, many challenges are still ahead, and several critical issues have to be addressed. Large band gap, and short life-time of photogenerated electrons and holes are critical issues negatively affect the photocatalytic activity of ZnO. Various approaches have been introduced to overcome these issues including intrinsic doping, extrinsic doping, and heterostructure. This review introduces unique and deep insights into tuning of the photocatalytic activity of ZnO. It starts by description of how to tune the photocatalytic activity of pristine ZnO through tuning its morphology, surface area, exposed face, and intrinsic defects. Afterward, the review explains how the Z-scheme approach succeed to address the redox weakened issue of heterojunction approach. In general, this review provides a clear image that helps the researcher to tune the photocatalytic activity of pristine ZnO and its heterostructure.

7.
Cell Biochem Funct ; 40(7): 729-741, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-36098489

RESUMO

The generation of advanced glycation end products (AGEs) through nonenzymatic protein glycation contributes to the pathogenesis of long-lived diabetic problems. Metformin (MTF) is the very first drug having antihyperglycemic effects on type II diabetes mellitus which also possess interaction with dicarbonyl compounds and blocks the formation of AGEs. In the current study, MTF is bioconjugated with glycation-derived synthesized gold nanoparticles (GNPs) of significant size. Additionally, using various biophysical and biochemical approaches, we investigated the antiglycating capacity MTF-GNPs in contrast to MTF against d-ribose-derived glycation of bovine serum albumin. Our key findings via utilizing various assays demonstrated that MTF-GNPs were able to inhibit AGEs development by reducing hyperchromicity, early glycation products, carbonyl content, hydxoxymethylfurfural content, production of fluorescent AGEs, normalizing the loss of secondary structure (i.e., α-helix and ß-sheets) of proteins, elevating the levels of free lysine and free arginine more efficiently compared to pure MTF. Based on these results, we concluded that MTF-GNPs possess a considerable antiglycation property and may be developed as an outstanding anti-AGEs treatment drug. Further in vivo and clinical research are necessary to determine the therapeutic effects of MTF-GNPs against AGE-related and metabolic disorders.


Assuntos
Diabetes Mellitus Tipo 2 , Nanopartículas Metálicas , Metformina , Arginina , Diabetes Mellitus Tipo 2/tratamento farmacológico , Produtos Finais de Glicação Avançada/metabolismo , Ouro , Humanos , Hipoglicemiantes/farmacologia , Lisina/química , Metformina/farmacologia , Ribose/química , Ribose/metabolismo , Soroalbumina Bovina/química , Soroalbumina Bovina/metabolismo
8.
J Pak Med Assoc ; 72(11): 2355-2360, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37013327

RESUMO

OBJECTIVE: To discover Pakistani adult population's perception about their general health, immune status and knowledge regarding immunity, and to highlight their efforts to improve it. METHODS: The knowledge-attitude-practice study was conducted from January to May 2021, after approval ethics review committee of the Islamic International Medical College, Rawalpindi, Pakistan, and comprised individuals of either gender from the community aged 18 years or more and not suffering from any physical disability or mental illness. Data was collected using a pre-tested, self-administered questionnaire that was disseminated through online platforms. The collected data was analysed using SPSS 25. RESULTS: All the 455(100%) individuals approached responded to the questionnaire. The mean age of the subjects was 22.6±7.579 years. There were 256(56.3%) female respondents, 283(62.2%) were aged 20-21 years, and 359(78.9%) hailed from the Sindh province. Most participants perceived their general health as 'good' 197(43.3%). The immune system function was reported 'good' by 200(44%), and the perception of general knowledge of immunity was reported 'good' by 189(41.5%) subjects. Inverse relationships were identified between stress levels and self-perceived health, and between receiving effective homeopathic treatment and 'very good' self-perceived immune status (p<0.05). People willing to take non-obligatory vaccines had a positive opinion about their self-perceived knowledge on immunity that produced a direct relationship (p<0.05). CONCLUSIONS: The findings provide a framework of practices that should be promoted to improve health status of adult population in Pakistan.


Assuntos
Povo Asiático , Conhecimentos, Atitudes e Prática em Saúde , Adulto , Humanos , Feminino , Adolescente , Adulto Jovem , Masculino , Paquistão/epidemiologia , Estudos Transversais , Inquéritos e Questionários
9.
S D Med ; 74(7): 306-309, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34449991

RESUMO

Chronic kidney disease affects nearly 15 percent of the U.S. population. Onset and rate of progression are influenced by a combination of genetic and non-genetic factors. Because health care systems across the U.S. are beginning to deploy automated decision support to stratify patients at risk, we review the relative impact of genetic factors (e.g., APOL1 gene polymorphisms) and non-genetic factors (e.g., clinical comorbidities and exposure to environmental nephrotoxins) contributing to this common disease. Overall, the impact of non-genetic factors appears to exceed the impact of genetic factors.


Assuntos
Insuficiência Renal Crônica , Apolipoproteína L1/genética , Humanos , Insuficiência Renal Crônica/epidemiologia , Insuficiência Renal Crônica/genética , Fatores de Risco
10.
J Surg Case Rep ; 2024(6): rjae412, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38863962

RESUMO

Necrotizing fasciitis, a rare, potentially life-threatening infection, often necessitates urgent medical intervention and surgical excision of the affected tissue. We present a 55-year-old male patient with a progressively enlarging lump in the left breast that was diagnosed as a breast carcinoma. Post-modified radical mastectomy, histopathological examination revealed Grade II invasive ductal carcinoma with neuroendocrine features. Due to financial constraints, the patient missed post-operative follow-ups and did not complete the prescribed radiotherapy sessions. Three months later, the patient returned with fever, swelling alongside sharp pain in the left arm and oozing blood. A clinical diagnosis of necrotizing fasciitis was made, leading to urgent surgical debridement. While the wound progressively healed, a contracture developed restricting elbow movement. An Orthopedic Review and Bone scintigraphy revealed metastasis of breast carcinoma to the sternum. This case report highlights the multi-disciplinary management required in such financially constrained rare cases in low- and middle-income countries.

11.
Artigo em Inglês | MEDLINE | ID: mdl-39363631

RESUMO

The reaction kinetics is predominantly determined by the surface and interface engineering of electrocatalysts. Herein, we demonstrate the growth of cobalt monophosphide and iron monophosphide (CoP/FeP) with an effective solid interface. The surface of CoP/FeP is mesoporous, which is obtained by phosphidizing mesoporous CoFe2O4. The CoP/FeP electrode exhibits substantially superior hydrogen evolution reaction (HER) performance compared to CoP and FeP. The overpotentials (η) required to generate 10 mA cm-2 are determined to be around 98 mVRHE (CoP/FeP), 220 mVRHE (FeP), and 265 mVRHE (CoP) in an acidic electrolyte. The exchange current density and Tafel slopes suggest that CoP/FeP has better redox properties and kinetic abilities compared to FeP and CoP. Furthermore, the CoP/FeP electrode exhibits reduced electrochemical impedance and superior surface charge transport characteristics in comparison to both the CoP and FeP electrodes. In addition to having a greater number of catalytically active sites, the turnover frequency of CoP/FeP is approximately 2 and 5 times higher than that of FeP and CoP, respectively. The CoP/FeP electrode maintains a consistent current density of around 25 mA cm-2 for a continuous period of 24 h during the HER, attesting to the excellent durability of the CoP/FeP electrode. In addition, a relationship between differential hydrogen adsorption energy (ΔEH), the corresponding Gibbs free energy change (ΔGH), and the hydrogen coverage on distinct surfaces, namely, CoP, FeP, and CoP/FeP, is established. The calculation findings show that the CoP/FeP surface, which is predominantly exposed with CoP, exhibits the highest catalytic potential for the HER. The estimation of the specific HER activity of the electrodes, normalized to the electrochemically active surface area, corroborates the calculation findings.

12.
Cureus ; 16(7): e63838, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-39100040

RESUMO

BACKGROUND:  Climate change (CC) persists as a critical public health concern, vividly demonstrated by Pakistan's severe unprecedented flooding from June to October 2022. The interplay between floods and CC highlights the urgent need to comprehend their complex dynamics. Given Pakistan's significant geographical vulnerability to CC events, assessing public awareness of CC becomes essential. This study aims to evaluate public knowledge, attitudes, and perception (KAP) regarding CC and its implications for overall health, reflecting onto governmental policies and community-based guidelines and enhancing preparedness for future natural calamities of similar magnitude. METHODS:  A nationwide cross-sectional survey of Pakistani adults covering all provinces of the country was conducted from January to March 2023 using a prevalidated questionnaire. A purposive sampling strategy was used to enroll participants in the study. Where appropriate, the chi-square test or Fisher's exact test was used to compare KAP among the sociodemographic groups. Multivariate analysis was used to explore predictors of knowledge. Crude and adjusted odds ratios (ORs) were calculated considering a p value of ≤0.05 as significant. RESULTS:  Among the 714 respondents, 265 (37.1%) of the respondents' residential areas were affected by the floods in Pakistan. A total of 663 (92.9%) of the participants had heard of CC, with 302 (42.3%) choosing "social media/WhatsApp" as their source of information. Increased flooding and changes in rainfall patterns were selected by 679 (95.1%) and 661 (92.6%) participants, respectively, as the most recognized CC. "Deforestation" was the most indicated reason for CC by 675 (94.5%) participants. Multivariate analysis revealed that females (OR: 1.31, 95% CI: 1.16-2.00; p < 0.001), individuals who were affected by recent floods (OR: 1.13, 95% CI: 1.05-3.34; p = 0.003), and individuals who were medical students/healthcare workers (OR: 1.49, 95% CI: 1.24-2.48; p < 0.001) had greater knowledge of CC than their counterparts. CONCLUSIONS:  The study reported an encouraging prevalence of knowledge of CC, positive attitudes, and practices toward CC, with an interest in learning and doing more to address the health effects of CC. With the ongoing global CC and a monsoon season forecast of similar intensity for the years to come in Pakistan, identifying groups with less knowledge of CC warrants a targeted education program to maximize awareness. Based on the study findings, social media platforms and interventions in educational institutes should be essential to mitigate the CC events in Pakistan and other vulnerable regions in the area.

13.
Chemosphere ; 362: 142630, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38897321

RESUMO

Microplastics (MPs) and their co-pollutants pose significant threats to soil and marine environments, necessitating understanding of their colonization processes to combat the plastic pandemic and protect ecosystems. MPs can act as invisible carriers, concentrating and transporting pollutants, leading to a more widespread and potentially toxic impact than the presence of either MPs or the pollutants alone. Analyzing the sorption and desorption dynamics of MPs is crucial for understanding pollutants amplification and predicting the fate and transport of pollutants in soil and marine environments. This review provides an in-depth analysis of the sorption and desorption dynamics of MPs, highlighting the importance of considering these dynamics in ecotoxicological risk assessment of MPs pollution. The review identifies limitations of current frameworks that neglect these interactions and proposes incorporating sorption and desorption data into robust frameworks to improve the ability to predict ecological risks posed by MPs and co-pollutants in soil and marine environments. However, failure to address the interplay between sorption and desorption can result in underestimation of the true impact of MPs and co-pollutants, affecting livelihoods and agro-employments, and exacerbate poverty and community disputes (SDGs 1, 2, 3, 8, 9, and 16). It can also affect food production and security (SDG 2), life below water and life on land (DSGs 14 and 15), cultural practices, and natural heritage (SDG 11.4). Hence, it is necessary to develop new approaches to ecotoxicological risk assessment that consider sorption and desorption processes in the interactions between the components in the framework to address the identified limitations.


Assuntos
Ecotoxicologia , Monitoramento Ambiental , Microplásticos , Poluentes do Solo , Solo , Poluentes Químicos da Água , Microplásticos/análise , Microplásticos/toxicidade , Microplásticos/química , Medição de Risco , Poluentes do Solo/análise , Poluentes do Solo/toxicidade , Poluentes do Solo/química , Monitoramento Ambiental/métodos , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/química , Poluentes Químicos da Água/toxicidade , Solo/química , Ecossistema , Adsorção
15.
J Burn Care Res ; 44(4): 949-954, 2023 07 05.
Artigo em Inglês | MEDLINE | ID: mdl-36305838

RESUMO

Burns carries a high-risk of mortality and morbidity. This with increased chances of drug-resistant infections makes the management complicated. Hence this study was conducted to find out the prevalence of multidrug-resistant organisms (MDRO) in burns patients admitted to the intensive care unit at a tertiary care hospital. A 2-year retrospective study was conducted where burn patients reporting MDRO were included. Statistical analysis was performed using SPSS version 26 where a P-value < .05 was considered statistically significant. Out of 97 patients, tissue cultures of 65 patients revealed the presence of MDRO in 27 (27.8%) patients. A male predominance (17, 63.0%) was noted with a mean age of 29.0-year-old. Fire burn (15, 55.6%) was reported to be the most common cause of burn with an average of 29.9% of Total Body Surface Area (TBSA) involved. MDR Pseudomonas aeruginosa was the commonest organism reported in 12 (44%) patients. The average length of stay (LOS) was noted to be 11.3 days with a mortality rate of 48.1% (overall, in all MDRO'S infections). Patients who reported MDRO showed a tendency for longer hospitalization with a higher risk of mortality as the TBSA increased. However, in presence of other factors in burns like higher TBSA, inhalation injury and lack of advanced skin substitute these mortality figures, and their association can be debated. Lastly, the implementation of control measures, as basic as hand hygiene, should be partaken to reduce the burden of MDR infections.


Assuntos
Queimaduras , Humanos , Masculino , Adulto , Feminino , Queimaduras/epidemiologia , Queimaduras/terapia , Queimaduras/complicações , Estudos Retrospectivos , Centros de Atenção Terciária , Farmacorresistência Bacteriana Múltipla , Prevalência , Unidades de Queimados , Unidades de Terapia Intensiva , Bactérias Gram-Negativas , Tempo de Internação
16.
ACS Omega ; 8(20): 18000-18008, 2023 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-37251143

RESUMO

In this research work, the mechanical properties of high-strength self-compacting concrete (HSSCC) were studied. Three mixes were selected, having compressive strengths of more than 70, 80, and 90 MPa, respectively. For these three mixes, the stress-strain characteristics were studied by casting cylinders. It was observed during the testing that the binder content and water-to-binder ratio influence the strength of HSSCC, and slow changes in stress-strain curves were seen as the strength increased. The use of HSSCC results in reduced bond cracking, leading to a more linear and steeper stress-strain curve in the ascending branches as the strength of the concrete increases. Elastic properties such as modulus of elasticity and Poisson's ratio of HSSCC were calculated using experimental data. In HSSCC, since the aggregate content is lower and the size of the aggregates is smaller, it will have a lower modulus of elasticity compared to normal vibrating concrete (NVC). Thus, an equation is proposed from the experimental results for predicting the modulus of elasticity of HSSCC. The results suggest that the proposed equation for predicting the elastic modulus of HSSCC for strengths ranging from 70 to 90 MPa is valid. It was also observed that the Poisson's ratio values for all three mixes of HSSCC were found to be lower than the typical value for NVC, indicating a higher degree of stiffness.

17.
ACS Omega ; 8(20): 17992-17999, 2023 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-37251169

RESUMO

High-performance concrete (HPC) is increasingly used in construction due to its superior strength and durability. However, current stress block parameters used for designing normal-strength concrete cannot be safely applied to HPC. To address this issue, new stress block parameters have been proposed through experimental works, which are used for designing HPC members. In this study, the behavior of HPC was investigated using these stress block parameters. Two-span beams made of HPC were tested under five-point bending, and an idealized stress block curve was derived from the experimental stress-strain curve for grades 60, 80, and 100 MPa. Based on the stress block curve, equations for the ultimate moment of resistance, depth of the neutral axis, limiting moment of resistance, and maximum depth of the neutral axis were proposed. An idealized load-deformation curve was also developed, which identified four significant events: first cracking, yielding of reinforced steel, crushing of concrete with spalling of cover, and ultimate failure. The predicted values were found to be in good agreement with the experimental values, and the average location of the first crack was identified to be 0.270 L, measured from the central support on either side of the span. These findings provide important insights for the design of HPC structures, contributing to the development of more resilient and durable infrastructure.

18.
Int J Nephrol Renovasc Dis ; 16: 17-30, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36660606

RESUMO

Aim: Nephrogenic systemic fibrosis (NSF) is a rare disorder that occurs in association majorly with chronic kidney disease (CKD). The lack of collective quantitative data on its clinical manifestations and the different treatment options' efficacy, call the need for our investigation. Methods: A systematic review was conducted covering a timeline from inception up to July 2022 without any restrictions. Article screening and data extraction were performed independently on PubMed, Google Scholar, ScienceDirect, and Cochrane Library. The keywords that we used were CKD, NSF, Gadolinium enduced fibrosis, etc; shortlisted articles were assessed for risk of bias. Data were presented as frequencies and percentages, with a confidence interval of 95%. A chi-square test was also done to find significant relationships, with a p-value <0.05 considered significant. Results: We had 83 patients in this review consisting of 44 (55.7%) females with a mean age of 51.4±14.6 years. Sixty-nine (83.1%) patients had chronic kidney disease predisposition to NSF. Previous exposure to gadolinium-based contrast dyes was seen in 66 (79.5%) patients). The most common symptom in patients was cutaneous lesions in 69 (83.1%) patients. The most used treatments were ultraviolet therapy, renal transplant, and extracorporeal photopheresis; in 13.3% of the patients each. Condition in most patients either improved (67.1%) or remained stable (11.8%). Chi-square testing found that the treatments offered were also seen to be significantly related to outcome (p=0.015). Conclusion: The findings in this study provide a quantitative measurement of NSF's presentations and treatment efficacies. This serves to make way for researchers to form comprehensive guidelines on the presentation-based treatment of NSF.

19.
ACS Appl Energy Mater ; 6(11): 5690-5699, 2023 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-37323204

RESUMO

The development of high current density anodes for the oxygen evolution reaction (OER) is fundamental to manufacturing practical and reliable electrochemical cells. In this work, we have developed a bimetallic electrocatalyst based on cobalt-iron oxyhydroxide that shows outstanding performance for water oxidation. Such a catalyst is obtained from cobalt-iron phosphide nanorods that serve as sacrificial structures for the formation of a bimetallic oxyhydroxide through phosphorous loss concomitantly to oxygen/hydroxide incorporation. CoFeP nanorods are synthesized using a scalable method using triphenyl phosphite as a phosphorous precursor. They are deposited without the use of binders on nickel foam to enable fast electron transport, a highly effective surface area, and a high density of active sites. The morphological and chemical transformation of the CoFeP nanoparticles is analyzed and compared with the monometallic cobalt phosphide in alkaline media and under anodic potentials. The resulting bimetallic electrode presents a Tafel slope as low as 42 mV dec-1 and low overpotentials for OER. For the first time, an anion exchange membrane electrolysis device with an integrated CoFeP-based anode was tested at a high current density of 1 A cm-2, demonstrating excellent stability and Faradaic efficiency near 100%. This work opens up a way for using metal phosphide-based anodes for practical fuel electrosynthesis devices.

20.
Ann Med Surg (Lond) ; 85(2): 92-101, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36845824

RESUMO

The renal system manifestations of coronavirus disease-2019 have been documented extensively; however, scientific literature remains scarce regarding collapsing glomerulopathy hence the need for this investigation. Methods: A comprehensive review was conducted covering a timeline from 1 January 2020 to 5 February 2022 without any restrictions. The data extraction was conducted independently, and articles were assessed for the risk of bias. Data analysis was conducted using Comprehensive Meta-Analysis version 3.3.070 and RevMan version 5.4 for pooled proportions and risk ratio (RR) between dialysis-dependent and independent treatment groups with a P-value less than 0.05 considered significant. Results: A total of 38 studies were included in this review, including 74 (65.9%) males. The mean age was 54.2 years old. The most common symptoms reported were related to the respiratory system (59.6%, 95% CI: 50.4-68.2%) and hematuria (34.2%, 95% CI: 26.1-43.4). Antibiotics (25.9%, 95% CI: 12.9-45.3%) was the commonest management used. Proteinuria was the most reported laboratory finding at 89.5% (95% CI: 82.4-93.9%), while the commonest microscopic finding was acute tubular injury (77.2%, 95% CI: 68.6-84.0%). An increased risk of the presence of symptoms (P=0.005) and microscopic findings (P=0.0003) related to collapsing glomerulopathy in dialysis-dependent group was noted with increased management (P=0.01) used in this group for coronavirus disease-2019 infection. Conclusion: The findings of this study portray the prognostic value of the variables (symptoms and microscopic findings, etc.) reported in the analysis. Hence this study serves as a foundation for future investigations that minimize the study's limitations to provide a more robust conclusion.

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