Knowledge, attitudes, and practice towards allergic rhinitis in patients with allergic rhinitis: a cross-sectional study.

BACKGROUND: The knowledge, attitude, and practice (KAP) of Chinese patients with allergic rhinitis (AR) on AR is poorly known. This study investigated the KAP towards AR in patients with this disease and explored the factors associated with KAP. METHODS: This cross-sectional study enrolled patients with AR in Zhangjiagang Hospital of Traditional Chinese Medicine between October 2022 and March 2023. RESULTS: This study included 656 valid questionnaires. Most participants were 26-35 years old (36.13%) and were female (55.18%). The knowledge, attitude, and practice scores were 5.70 ± 2.88 (possible range: 0-12), 29.51 ± 3.52 (possible range: 9-45), and 34.13 ± 7.55 (possible range: 9-45), indicating poor knowledge, unfavorable attitudes, and proactive practice. AR history of 3-5 years (adjusted odds ratio (adjOR) = 1.62, 95% confidence interval (CI): 1.03-2.54, P = 0.037), AR history of > 6 years (adjOR = 1.64, 95%CI: 1.06-2.54, P = 0.027), and know their own allergens (adjOR = 2.34, 95%CI: 1.28-4.25, P = 0.005) were independently associated with the sufficient knowledge. AR history of ≥ 6 years (adjOR = 0.60, 95%CI: 0.37-0.96, P = 0.035), and liking sports (adjOR = 1.58, 95%CI = 1.07-2.33, P = 0.020) were independently associated with the positive attitude. The knowledge scores (adjOR = 1.14, 95%CI: 1.05-1.22, P = 0.001), attitude scores (adjOR = 1.24, 95%CI: 1.17-1.32, P < 0.001), age 36-45 (adjOR = 2.13, 95%CI: 1.19-3.82, P = 0.011), employed (adjOR = 0.59, 95%CI: 0.37-0.94, P = 0.026), and liking sports (adjOR = 2.11, 95%CI: 1.43-3.14, P < 0.001) were independently associated with the proactive practice. CONCLUSIONS: Patients with AR have poor knowledge and unfavorable attitudes but good practice toward AR. Continuous quality teaching interventions and education on patients for AR were recommended.

Trophic Niche Differentiation in Two Sympatric Nuthatch Species (Sitta yunnanensis and Sitta nagaensis).

Sympatric closely related species may experience interspecific trophic competition due to ecological similarity; they may isolate in terms of diet or habitat use as a strategy to avoid competition. The body tissues of consumers contain stable isotope signatures information that can be applied to infer their dietary information. In this study, δ13C and δ15N stable isotopes were analyzed to determine the dietary information and trophic niches of sympatric coexisting Sitta yunnanensis and Sitta nagaensis. The results showed that the food sources of S. yunnanensis and S. nagaensis were from six orders, including Orthoptera, and the cumulative contribution rate was 99.97%, with the two species eating similar diets but at different rates. The larger δ13C of S. yunnanensis indicates that it had a wider range of habitats for feeding, while the difference in δ15N values was not significant (p > 0.05), indicating that both species feed on similar nutrient levels. As determined by Bayesian ellipses, the isotopic niches of S. yunnanensis and S. nagaensis were differentiated; the isotopic niche width of S. yunnanensis is 2.69‱2, which was larger than that of S. nagaensis (0.73‱2), indicates that differentiation between the two species in diet or habitat use reduced competition. Trophic niche differentiation and differences in foraging proportions may be the principal resource allocation mechanisms behind S. yunnanensis and S. nagaensis coexistence.

Two new species of Rhopalopsole (Plecoptera: Leuctridae) from China.

Two new species of the leuctrid genus Rhopalopsole from China are described, R. curvispina Qian & Du, sp. nov. and R. triseriata Qian & Du, sp. nov. The new species are compared to similar species in R. dentata group and R. magnicercia group.

Review of stick insects (Insecta: Phasmatodea) from Yintiaoling Nature Reserve of China, with description of two new species.

This is the first investigation of stick insect from the Yintiaoling National Nature Reserve, Chongqing of China. Totally seven species were collected. Four of them belong to the subfamily Clitumninae of Phasmatidae: Interphasma emeiense Chen & He, 2008, Paraentoria sichuanensis Chen & He, 1997, Parabaculum wushanense (Chen & He, 1997) and Baculonistria alba (Chen & He, 1990). The other three belong to the subfamily Necrosciinae of Lonchodidae, including two new species: Micadina conifera Chen & He, 1997, Hemisosibia yintiaolingensis sp. nov. and Dianphasma chongqingensis sp. nov..

Flowerbed-Inspired Biomimetic Scaffold with Rapid Internal Tissue Infiltration and Vascularization Capacity for Bone Repair.

The favorable microstructure and bioactivity of tissue-engineered bone scaffolds are closely associated with the regenerative efficacy of bone defects. For the treatment of large bone defects, however, most of them fail to meet requirements such as adequate mechanical strength, highly porous structure, and excellent angiogenic and osteogenic activities. Herein, inspired by the characteristics of a "flowerbed", we construct a short nanofiber aggregates-enriched dual-factor delivery scaffold via 3D printing and electrospinning techniques for guiding vascularized bone regeneration. By the assembly of short nanofibers containing dimethyloxalylglycine (DMOG)-loaded mesoporous silica nanoparticles with a 3D printed strontium-contained hydroxyapatite/polycaprolactone (SrHA@PCL) scaffold, an adjustable porous structure can be easily realized by changing the density of nanofibers, while strong compressive strength will be acquired due to the framework role of SrHA@PCL. Owing to the different degradation performance between electrospun nanofibers and 3D printed microfilaments, a sequential release behavior of DMOG and Sr ions is achieved. Both in vivo and in vitro results demonstrate that the dual-factor delivery scaffold has excellent biocompatibility, significantly promotes angiogenesis and osteogenesis by stimulating endothelial cells and osteoblasts, and effectively accelerates tissue ingrowth and vascularized bone regeneration through activating the hypoxia inducible factor-1α pathway and immunoregulatory effect. Overall, this study has provided a promising strategy for constructing a bone microenvironment-matched biomimetic scaffold for bone regeneration.

Two new combinations of Medaurini (Phasmatodea: Phasmatidae: Clitumninae) from Yunnan Province, China.

Two new combinations are proposed for Chinese species previously described in the endemic Australian genus Pachymorpha Gray, 1835: Interphasma belocerca (Chen & He, 2008) comb. nov., of which the male and egg are described are illustrated for the first time and Neomedaura arguta (Chen & He, 2008) comb. nov., the first report of the genus Neomedaura Ho, 2020, in China.

A new stonefly species, Rhopalopsole tricuspis (Leuctridae: Plecoptera), and three new records of stoneflies from the Qinling Mountains of Shaanxi, China.

Plecopteran species (Leuctridae) were collected from the Qinling Mountains in southern Shaanxi Province, China. This mountain range is home to nine species of Leuctridae belonging to two genera, and the species identified in this work include one new species and three new records for the Qinling Mountains, all belonging to the genus Rhopalopsole. The new species is named R. tricuspis Qian and Du, sp. nov. A redescription of R. basinigra Yang and Yang 1995 is supplemented. A key is provided for the adult males of Leuctridae from the Qinling Mountains.

New species of Andropromachus (Phasmatodea: Lonchodidae: Necrosciinae: Necrosciini) from Yunnan Province, China.

BACKGROUND: The genus Andropromachus (Lonchodidae: Necrosciinae: Necrosciini) is a small genus of stick insects including four species with a distribution in northern Vietnam and south-western China. NEW INFORMATION: A new species of stick insects Andropromachusgulinqingensis sp. n. is described from Yunnan Province of China. Diagnostic characters of the new species are illustrated and an identification key to male and female Andropromachus is provided along with a checklist for all described species.

First record of the genus Medaura Stål (Phasmatodea, Phasmatidae, Clitumninae) from China, with description of a new species.

Background: The stick insect tribe, Medaurini in subfamily Clitumniae, contains 11 genera and 75 known species, with species diversity of this tribe being rich in southeast Asia and China, as is reflected in the Phasmida Species File Online [PSF]. The genus Medaura includes four named species and they are distributed over Bangladesh, Indonesia and India. The discovery of this new species in Xishuangbanna Dai Autonomous Prefecture marks the first identification of the genus Medaura in China. New information: The genus Medaura Stål is reported for the first time from China, based on a new species M.aculeiformis Xie & Qian sp. n. and the identification characteristics of species are described and illustrated in this paper.

Vascularized nanocomposite hydrogel mechanically reinforced by polyelectrolyte-modified nanoparticles.

Vascularization plays an important role in the initial stage of triggering bone defect repair. The combination of bioactive small molecule drugs and biomaterials has been a powerful strategy for vascularization in bone tissue engineering. In this study, an in situ crosslinked aldehyde hyaluronic acid (AHA)/N,O-carboxymethyl chitosan (NOCC) nanocomposite hydrogel doped with sphingosine 1-phosphate (S1P)-loaded polyelectrolyte-modified mesoporous silica nanoparticles (MSNs) was developed. The alginate/chitosan polyelectrolyte-modified MSNs (MSNs-ALG/CHI) were prepared via the electrostatic interaction. The incorporation of MSNs-ALG/CHI not only achieved a sustained release profile of the angiogenic drug, but also improved the mechanical property of the AHA/NOCC hydrogel due to the Schiff base reaction between the amino group in chitosan and the aldehyde group in AHA. In addition, in vitro cell experiments demonstrated that the nanocomposite hydrogel provided favorable support for cell adhesion and proliferation, and the S1P-loaded nanocomposite hydrogel was able to recruit endothelial cells. More importantly, the chicken chorioallantoic membrane (CAM) assay confirmed that the S1P-loaded nanocomposite hydrogel could significantly enhance capillary formation. More cell infiltration and better angiogenesis in the S1P loaded nanocomposite hydrogel were observed compared to the group without S1P loading after being implanted subcutaneously for 2 weeks. Furthermore, the subcutaneous implantation experiment further demonstrated that the incorporation of the S1P-loaded nanocomposite hydrogel could improve the tissue infiltration and new vessel formation within the macroporous poly(L-lactic acid)/polycaprolactone scaffold. Our results suggest that the nanocomposite hydrogel will be an excellent drug delivery system and the S1P-loaded nanocomposite hydrogel has great potential for vascularized bone regeneration application.

Recent Advances in the Enzyme-Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy.

The exploration of advanced probes for cancer diagnosis and treatment is of high importance in fundamental research and clinical practice. In comparison with the traditional "always-on" probes, the emerging activatable probes enjoy advantages in promoted accuracy for tumor theranostics by specifically releasing or activating fluorophores at the targeting sites. The main designing principle for these probes is to incorporate responsive groups that can specifically react with the biomarkers (e. g., enzymes) involved in tumorigenesis and progression, realizing the controlled activation in tumors. In this review, we summarize the latest advances in the molecular design and biomedical application of enzyme-responsive organic fluorescent probes. Particularly, the fluorophores can be endowed with ability of generating reactive oxygen species (ROS) to afford the photosensitizers, highlighting the potential of these probes in simultaneous tumor imaging and therapy with rational design. We hope that this review could inspire more research interests in the development of tumor-targeting theranostic probes for advanced biological studies.

Two new species of Mesonemoura (Plecoptera: Nemouridae) from Yunnan Province of China.

Two new species of the nemourid genus Mesonemoura from Yunnan Province of southwestern China are described, M. longiflagellata Xiao Qian sp. nov. from Pudatcuo National Park of Shangri-la City and M. tumida Qian Du sp. nov. from Cangshan Mountian of Dali City. The male and female terminalia of the new species are compared to related species.

Two new species of Sphaeronemoura (Plecoptera: Nemouridae) from Yunnan Province of China.

Two new species of the nemourid genus Sphaeronemoura are described based on males and females collected from Yunnan Province of southwestern China. The new taxa include S. kunmingensis Qian Du sp. nov. and S. campylura Qian Du sp. nov.. The new species are compared to related taxa.

A new species of Agnetina from China with redescription of Paragnetina indentata Wu amp; Claassen, 1934 (Plecoptera: Perlidae).

A new species of genus Agnetina (Plecoptera: Perlidae), Agnetina donans Qian Du sp. nov. from Xinjiang Uygur Autonomous Region of China is described from males and females. Additionally, Paragnetina indentata Wu Claassen, 1934 is redescribed from two males and a female collected from Mt. Gaoligong, Yunnan Province in southwestern China.

A remarkable new species of Nemoura (Plecoptera: Nemouridae) from Chuxiong Yi Autonomous Prefecture of Yunnan Province, China.

A new species of the genus Nemoura, N. latilongispina sp. nov. from Chuxiong Yi Autonomous Prefecture of Yunnan Province, southwestern China is described and illustrated. The new species is characterized by ventral sclerite of epiproct extended laterally, forming upcurved plates fringed with long spines along upper margin, and by the strongly sclerotized, fork-shaped cercus.

Two new species of Rhopalopsole (Plecoptera: Leuctridae) from China.

Two new species of the genus Rhopalopsole, R. brevidigitata Qian & Du, sp. nov. and R. faciursina Qian & Du, sp. nov. are described and illustrated from Yunnan Province of southwestern China. The new species are compared to similar taxa in the R. vietnamica and R. shaanxiensis groups, respectively.