Detalhe da pesquisa
1.
Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis.
BMC Biol
; 20(1): 147, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35729566
2.
The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis.
Mol Microbiol
; 99(4): 794-807, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26538472
3.
HadBD dehydratase from Mycobacterium tuberculosis fatty acid synthase type II: A singular structure for a unique function.
Protein Sci
; 33(4): e4964, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38501584
4.
Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13.
J Biol Chem
; 287(40): 33675-90, 2012 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22825853
5.
A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone.
J Biol Chem
; 287(46): 38434-41, 2012 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23002234
6.
Acylation of glycerolipids in mycobacteria.
Nat Commun
; 14(1): 6694, 2023 10 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37872138
7.
Negative regulation by Ser/Thr phosphorylation of HadAB and HadBC dehydratases from Mycobacterium tuberculosis type II fatty acid synthase system.
Biochem Biophys Res Commun
; 412(3): 401-6, 2011 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21819969
8.
Chemical synthesis, biological evaluation and structure-activity relationship analysis of azaisoindolinones, a novel class of direct enoyl-ACP reductase inhibitors as potential antimycobacterial agents.
Bioorg Med Chem
; 19(21): 6225-32, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21975068
9.
Revisiting the assignment of Rv0241c to fatty acid synthase type II of Mycobacterium tuberculosis.
J Bacteriol
; 192(15): 4037-44, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20511508
10.
Correction: Pleiotropic Effect of AccD5 and AccE5 Depletion in Acyl-Coenzyme A Carboxylase Activity and in Lipid Biosynthesis in Mycobacteria.
PLoS One
; 15(11): e0242528, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33175908
11.
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis.
Sci Rep
; 10(1): 2112, 2020 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32034201
12.
Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family.
Biochim Biophys Acta
; 1774(2): 303-11, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17240207
13.
HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness.
Sci Rep
; 8(1): 6034, 2018 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29662082
14.
Functional reconstitution of the Mycobacterium tuberculosis long-chain acyl-CoA carboxylase from multiple acyl-CoA subunits.
FEBS J
; 284(7): 1110-1125, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28222482
15.
Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J Mol Biol
; 429(10): 1554-1569, 2017 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28377293
16.
New Insights into the Mycolate-Containing Compound Biosynthesis and Transport in Mycobacteria.
Trends Microbiol
; 24(9): 725-738, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27268593
17.
Evaluation of the inhibitory activity of (aza)isoindolinone-type compounds: toward in vitro InhA action, Mycobacterium tuberculosis growth and mycolic acid biosynthesis.
Chem Biol Drug Des
; 88(5): 740-755, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27301022
18.
Ligand-induced fit in mycobacterial MabA: the sequence-specific C-terminus locks the conformational change.
Proteins
; 60(3): 392-400, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15977159
19.
Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis.
J Mol Biol
; 320(2): 249-61, 2002 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12079383
20.
The Non-Essential Mycolic Acid Biosynthesis Genes hadA and hadC Contribute to the Physiology and Fitness of Mycobacterium smegmatis.
PLoS One
; 10(12): e0145883, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26701652