1.
Org Biomol Chem
; 12(30): 5634-44, 2014 Aug 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24962358
RESUMO
A general and efficient approach was developed for the introduction of S-functionality at the C-5 position of cytosine and uracil nucleosides and their analogues. The key step is a palladium-catalyzed C-S coupling of the corresponding 5-bromo nucleoside derivative and alkyl thiol. The butyl 3-mercaptopropionate coupling products were further converted to the corresponding disulphides, the stable precursors of 5-mercaptopyrimidine nucleosides.