Pesquisa | BVS IEC

1.

Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning.

McCurdy, Shannon R; Radojcic, Vedran; Tsai, Hua-Ling; Vulic, Ante; Thompson, Elizabeth; Ivcevic, Sanja; Kanakry, Christopher G; Powell, Jonathan D; Lohman, Brian; Adom, Djamilatou; Paczesny, Sophie; Cooke, Kenneth R; Jones, Richard J; Varadhan, Ravi; Symons, Heather J; Luznik, Leo.

Blood ; 139(4): 608-623, 2022 01 27.

Artigo em Inglês | MEDLINE | ID: mdl-34657151

2.

BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.

Jia, Wei; Poe, Jonathan C; Su, Hsuan; Anand, Sarah; Matsushima, Glenn K; Rathmell, Jeffrey C; Maillard, Ivan; Radojcic, Vedran; Imai, Kazuhiro; Reyes, Nancy J; Cardona, Diana M; Li, Zhiguo; Suthers, Amy N; Curry-Chisolm, Itaevia M; DiCioccio, Rachel A; Saban, Daniel R; Chen, Benny J; Chao, Nelson J; Sarantopoulos, Stefanie.

Blood ; 137(18): 2544-2557, 2021 05 06.

Artigo em Inglês | MEDLINE | ID: mdl-33534893

3.

Adoptive transfer of IL-4 reprogrammed Tc17 cells elicits anti-tumour immunity through functional plasticity.

Liu, Chiung-Hui; Lin, Bo-Shiou; Wu, Mei-Yao; Song, Ying-Chyi; Ke, Tao-Wei; Chou, Yu-Lun; Liu, Chuan-Teng; Lin, Chia-Hsin; Radojcic, Vedran; Drake, Charles; Yen, Hung-Rong.

Immunology ; 166(3): 310-326, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35322421

4.

Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4⁺ T Cells in Graft-versus-Host Disease.

Chung, Jooho; Radojcic, Vedran; Perkey, Eric; Parnell, Timothy J; Niknafs, Yashar; Jin, Xi; Friedman, Ann; Labrecque, Nathalie; Blazar, Bruce R; Brennan, Todd V; Siebel, Christian W; Maillard, Ivan.

J Immunol ; 203(2): 557-568, 2019 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-31182480

5.

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice.

Radojcic, Vedran; Paz, Katelyn; Chung, Jooho; Du, Jing; Perkey, Eric T; Flynn, Ryan; Ivcevic, Sanja; Zaiken, Michael; Friedman, Ann; Yan, Minhong; Pletneva, Maria A; Sarantopoulos, Stefanie; Siebel, Christian W; Blazar, Bruce R; Maillard, Ivan.

Blood ; 132(20): 2188-2200, 2018 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-30181175

6.

Transient blockade of delta-like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation.

Wood, Sherri; Feng, Jiane; Chung, Jooho; Radojcic, Vedran; Sandy-Sloat, Ashley R; Friedman, Ann; Shelton, Amy; Yan, Minhong; Siebel, Christian W; Bishop, D Keith; Maillard, Ivan.

J Immunol ; 194(6): 2899-908, 2015 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-25687759

7.

Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders.

Chiang, Mark Y; Radojcic, Vedran; Maillard, Ivan.

Curr Opin Hematol ; 23(4): 362-70, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27135981

8.

Hedgehog blockade in steroid-refractory sclerotic chronic graft-versus-host disease.

Radojcic, Vedran; Pletneva, Maria; Lee, Catherine J; Ivcevic, Sanja; Sarantopoulos, Stefanie; Couriel, Daniel.

Br J Haematol ; 195(2): e120-e122, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34142367

9.

PTCY keeps on giving!

Radojcic, Vedran; Luznik, Leo.

Blood ; 134(11): 848-849, 2019 09 12.

Artigo em Inglês | MEDLINE | ID: mdl-31515227

10.

The role of extracorporeal photopheresis in chronic graft-versus-host disease.

Radojcic, Vedran; Pletneva, Maria A; Couriel, Daniel R.

Transfus Apher Sci ; 52(2): 157-61, 2015 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-25716169

11.

Notching up B-cell pathology in chronic GVHD.

Radojcic, Vedran; Luznik, Leo.

Blood ; 130(19): 2053-2054, 2017 11 09.

Artigo em Inglês | MEDLINE | ID: mdl-29122773

12.

Multifaceted Burden of Chronic Graft-versus-Host Disease.

Radojcic, Vedran; Lee, Catherine J; Couriel, Daniel R.

Biol Blood Marrow Transplant ; 24(9): 1774-1775, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-30016655

13.

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.

Zhang, Yi; Sandy, Ashley R; Wang, Jina; Radojcic, Vedran; Shan, Gloria T; Tran, Ivy T; Friedman, Ann; Kato, Koji; He, Shan; Cui, Shuaiying; Hexner, Elizabeth; Frank, Dale M; Emerson, Stephen G; Pear, Warren S; Maillard, Ivan.

Blood ; 117(1): 299-308, 2011 Jan 06.

Artigo em Inglês | MEDLINE | ID: mdl-20870902

14.

Axatilimab for Chronic Graft-Versus-Host Disease After Failure of at Least Two Prior Systemic Therapies: Results of a Phase I/II Study.

Kitko, Carrie L; Arora, Mukta; DeFilipp, Zachariah; Zaid, Mohammad Abu; Di Stasi, Antonio; Radojcic, Vedran; Betts, Courtney B; Coussens, Lisa M; Meyers, Michael L; Qamoos, Hope; Ordentlich, Peter; Kumar, Vinit; Quaranto, Christine; Schmitt, Aaron; Gu, Yu; Blazar, Bruce R; Wang, Trent P; Salhotra, Amandeep; Pusic, Iskra; Jagasia, Madan; Lee, Stephanie J.

J Clin Oncol ; 41(10): 1864-1875, 2023 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-36459673

15.

STAT3 signaling in CD4+ T cells is critical for the pathogenesis of chronic sclerodermatous graft-versus-host disease in a murine model.

Radojcic, Vedran; Pletneva, Maria A; Yen, Hung-Rong; Ivcevic, Sanja; Panoskaltsis-Mortari, Angela; Gilliam, Anita C; Drake, Charles G; Blazar, Bruce R; Luznik, Leo.

J Immunol ; 184(2): 764-74, 2010 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-19995899

16.

Immune dysfunction signatures predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia.

Rutella, Sergio; Vadakekolathu, Jayakumar; Mazziotta, Francesco; Reeder, Stephen; Yau, Tung-On; Mukhopadhyay, Rupkatha; Dickins, Benjamin; Altmann, Heidi; Kramer, Michael; Knaus, Hanna A; Blazar, Bruce R; Radojcic, Vedran; Zeidner, Joshua F; Arruda, Andrea; Wang, Bofei; Abbas, Hussein A; Minden, Mark D; Tasian, Sarah K; Bornhäuser, Martin; Gojo, Ivana; Luznik, Leo.

J Clin Invest ; 132(21)2022 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-36099049

17.

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report.

Wolff, Daniel; Radojcic, Vedran; Lafyatis, Robert; Cinar, Resat; Rosenstein, Rachel K; Cowen, Edward W; Cheng, Guang-Shing; Sheshadri, Ajay; Bergeron, Anne; Williams, Kirsten M; Todd, Jamie L; Teshima, Takanori; Cuvelier, Geoffrey D E; Holler, Ernst; McCurdy, Shannon R; Jenq, Robert R; Hanash, Alan M; Jacobsohn, David; Santomasso, Bianca D; Jain, Sandeep; Ogawa, Yoko; Steven, Philipp; Luo, Zhonghui Katie; Dietrich-Ntoukas, Tina; Saban, Daniel; Bilic, Ervina; Penack, Olaf; Griffith, Linda M; Cowden, Meredith; Martin, Paul J; Greinix, Hildegard T; Sarantopoulos, Stefanie; Socie, Gerard; Blazar, Bruce R; Pidala, Joseph; Kitko, Carrie L; Couriel, Daniel R; Cutler, Corey; Schultz, Kirk R; Pavletic, Steven Z; Lee, Stephanie J; Paczesny, Sophie.

Transplant Cell Ther ; 27(10): 817-835, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34217703

18.

Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination.

Radojcic, Vedran; Bezak, Karl B; Skarica, Mario; Pletneva, Maria A; Yoshimura, Kiyoshi; Schulick, Richard D; Luznik, Leo.

Cancer Immunol Immunother ; 59(1): 137-48, 2010 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-19590872

19.

Mechanism of action of posttransplantation cyclophosphamide: more than meets the eye.

Radojcic, Vedran; Luznik, Leo.

J Clin Invest ; 129(6): 2189-2191, 2019 05 06.

Artigo em Inglês | MEDLINE | ID: mdl-31063990

20.

Rapamycin promotes emergence of IL-10-secreting donor lymphocyte infusion-derived T cells without compromising their graft-versus-leukemia reactivity.

Durakovic, Nadira; Radojcic, Vedran; Powell, Jonathan; Luznik, Leo.

Transplantation ; 83(5): 631-40, 2007 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-17353785

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Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning.

BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.

Adoptive transfer of IL-4 reprogrammed Tc17 cells elicits anti-tumour immunity through functional plasticity.

Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4⁺ T Cells in Graft-versus-Host Disease.

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice.

Transient blockade of delta-like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation.

Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders.

Hedgehog blockade in steroid-refractory sclerotic chronic graft-versus-host disease.

PTCY keeps on giving!

The role of extracorporeal photopheresis in chronic graft-versus-host disease.

Notching up B-cell pathology in chronic GVHD.

Multifaceted Burden of Chronic Graft-versus-Host Disease.

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.

Axatilimab for Chronic Graft-Versus-Host Disease After Failure of at Least Two Prior Systemic Therapies: Results of a Phase I/II Study.

STAT3 signaling in CD4+ T cells is critical for the pathogenesis of chronic sclerodermatous graft-versus-host disease in a murine model.

Immune dysfunction signatures predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia.

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report.

Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination.

Mechanism of action of posttransplantation cyclophosphamide: more than meets the eye.

Rapamycin promotes emergence of IL-10-secreting donor lymphocyte infusion-derived T cells without compromising their graft-versus-leukemia reactivity.