Recent Advances, Challenges, and Future Perspectives of ZnO Nanostructure Materials Towards Energy Applications.

In this approach, zinc oxide (ZnO) is a multipurpose substance with remarkable characteristics such as high sensitivity, a large specific area, non-toxicity, excellent compatibility, and a high isoelectric point, which make it attractive for discussion with some limitations. It is the most favorable possible option for the collection of nanostructures in terms of structure and their characteristics. The development of numerous ZnO nanostructure-based electrochemical sensors and biosensors used in health diagnosis, pharmaceutical evaluation, food hygiene, and contamination of the environment monitoring is described, as well as the production of ZnO nanostructures. Nanostructured ZnO has good chemical and temperature durability as an n-type semiconducting material, making it useful in a wide range of uses, from luminous materials to supercapacitors, batteries, solar cells, photocatalysis, biosensors, medicinal devices, and more. When compared to the bulk materials, the nanosized materials have both a higher rate of disintegration and a higher solubility. Furthermore, ZnO nanoparticles are regarded as top contenders for electrochemical sensors due to their strong electrochemical behaviors and electron transmission characteristics. The impact of many factors, including selectivity, sensitivity, detection limit, strength, and structures, arrangements, and their respective functioning processes, has been investigated. This study concentrated a substantial amount of its attention on the recent advancements that have been made in ZnO-based nanoparticles, composites, and modified materials for use in the application areas of energy storage and conversion devices as well as biological applications. Supercapacitors, Li-ion batteries, dye-sensitized solar cells, photocatalysis, biosensors, medicinal, and biological systems have been studied. ZnO-based materials are constantly analyzed for their advantages in energy and life science applications.

Progress and Perspectives on Promising Covalent-Organic Frameworks (COFs) Materials for Energy Storage Capacity.

In recent years, a new class of highly crystalline advanced permeable materials covalent-organic frameworks (COFs) have garnered a great deal of attention thanks to their remarkable properties, such as their large surface area, highly ordered pores and channels, and controllable crystalline structures. The lower physical stability and electrical conductivity, however, prevent them from being widely used in applications like photocatalytic activities and innovative energy storage and conversion devices. For this reason, many studies have focused on finding ways to improve upon these interesting materials while also minimizing their drawbacks. This review article begins with a brief introduction to the history and major milestones of COFs development before moving on to a comprehensive exploration of the various synthesis methods and recent successes and signposts of their potential applications in carbon dioxide (CO2 ) sequestration, supercapacitors (SCs), lithium-ion batteries (LIBs), and hydrogen production (H2 -energy). In conclusion, the difficulties and potential of future developing with highly efficient COFs ideas for photocatalytic as well as electrochemical energy storage applications are highlighted.

Gold Fluorescence Nanoparticles for Enhanced SERS Detection in Biomedical Sensor Applications: Current Trends and Future Directions.

Nanotechnology has emerged as a pivotal tool in biomedical research, particularly in developing advanced sensing platforms for disease diagnosis and therapeutic monitoring. Since gold nanoparticles are biocompatible and have special optical characteristics, they are excellent choices for surface-enhanced Raman scattering (SERS) sensing devices. Integrating fluorescence characteristics further enhances their utility in real-time imaging and tracking within biological systems. The synergistic combination of SERS and fluorescence enables sensitive and selective detection of biomolecules at trace levels, providing a versatile platform for early cancer diagnosis and drug monitoring. In cancer detection, AuNPs facilitate the specific targeting of cancer biomarkers, allowing for early-stage diagnosis and personalized treatment strategies. The enhanced sensitivity of SERS, coupled with the tunable fluorescence properties of AuNPs, offers a powerful tool for the identification of cancer cells and their microenvironment. This dual-mode detection not only improves diagnostic accuracy but also enables the monitoring of treatment response and disease progression. In drug detection, integrating AuNPs with SERS provides a robust platform for identifying and quantifying pharmaceutical compounds. The unique spectral fingerprints obtained through SERS enable the discrimination of drug molecules even in complex biological matrices. Furthermore, the fluorescence property of AuNPs makes it easier to track medication distribution in real-time, maximizing therapeutic effectiveness and reducing adverse effects. Furthermore, the review explores the role of gold fluorescence nanoparticles in photodynamic therapy (PDT). By using the complementary effects of targeted drug release and light-induced cytotoxicity, SERS-guided drug delivery and photodynamic therapy (PDT) can increase the effectiveness of treatment against cancer cells. In conclusion, the utilization of gold fluorescence nanoparticles in conjunction with SERS holds tremendous potential for revolutionizing cancer detection, drug analysis, and photodynamic therapy. The dual-mode capabilities of these nanomaterials provide a multifaceted approach to address the challenges in early diagnosis, treatment monitoring, and personalized medicine, thereby advancing the landscape of biomedical applications.

Chemistry Aspects and Designing Strategies of Flexible Materials for High-Performance Flexible Lithium-Ion Batteries.

In recent years, flexible and wearable electronics such as smart cards, smart fabrics, bio-sensors, soft robotics, and internet-linked electronics have impacted our lives. In order to meet the requirements of more flexible and adaptable paradigm shifts, wearable products may need to be seamlessly integrated. A great deal of effort has been made in the last two decades to develop flexible lithium-ion batteries (FLIBs). The selection of suitable flexible materials is important for the development of flexible electrolytes self-supported and supported electrodes. This review is focused on the critical discussion of the factors that evaluate the flexibility of the materials and their potential path toward achieving the FLIBs. Following this analysis, we present how to evaluate the flexibility of the battery materials and FLIBs. We describe the chemistry of carbon-based materials, covalent-organic frameworks (COFs), metal-organic frameworks (MOFs), and MXene-based materials and their flexible cell design that represented excellent electrochemical performances during bending. Furthermore, the application of state-of-the-art solid polymer and solid electrolytes to accelerate the development of FLIBs is introduced. Analyzing the contributions and developments of different countries has also been highlighted in the past decade. In addition, the prospects and potential of flexible materials and their engineering are also discussed, providing the roadmap for further developments in this fast-evolving field of FLIB research.

Bioresource Polymer Composite for Energy Generation and Storage: Developments and Trends.

The ever-growing demand of human society for clean and reliable energy sources spurred a substantial academic interest in exploring the potential of biological resources for developing energy generation and storage systems. As a result, alternative energy sources are needed in populous developing countries to compensate for energy deficits in an environmentally sustainable manner. This review aims to evaluate and summarize the recent progress in bio-based polymer composites (PCs) for energy generation and storage. The articulated review provides an overview of energy storage systems, e. g., supercapacitors and batteries, and discusses the future possibilities of various solar cells (SCs), using both past research progress and possible future developments as a basis for discussion. These studies examine systematic and sequential advances in different generations of SCs. Developing novel PCs that are efficient, stable, and cost-effective is of utmost importance. In addition, the current state of high-performance equipment for each of the technologies is evaluated in detail. We also discuss the prospects, future trends, and opportunities regarding using bioresources for energy generation and storage, as well as the development of low-cost and efficient PCs for SCs.

Synthesis of Electrical Conductive Metal-Organic Frameworks for Electrochemical Applications.

Electrical conductivity is very important property of nanomaterials for using wide range of applications especially energy applications. Metal-organic frameworks (MOFs) are notorious for their low electrical conductivity and less considered for usage in pristine forms. However, the advantages of high surface area, porosity and confined catalytic active sites motivated researchers to improve the conductivity of MOFs. Therefore, 2D electrical conductive MOFs (ECMOF) have been widely synthesized by developing the effective synthetic strategies. In this article, we have summarized the recent trends in developing the 2D ECMOFs, following the summary of potential applications in the various fields with future perspectives.

Recent Advances of Transition Metal Dichalcogenides-Based Materials for Energy Storage Devices, in View of Monovalent to Divalent Ions.

The fast growth of electrochemical energy storage (EES) systems necessitates using innovative, high-performance electrode materials. Among the various EES devices, rechargeable batteries (RBs) with potential features like high energy density and extensive lifetime are well suited to meet rapidly increasing energy demands. Layered transition metal dichalcogenides (TMDs), typical two dimensional (2D) nanomaterial, are considered auspicious materials for RBs because of their layered structures and large specific surface areas (SSA) that benefit quick ion transportation. This review summarizes and highlights recent advances in TMDs with improved performance for various RBs. Through novel engineering and functionalization used for high-performance RBs, we briefly discuss the properties, characterizations, and electrochemistry phenomena of TMDs. We summarised that engineering with multiple techniques, like nanocomposites used for TMDs receives special attention. In conclusion, the recent issues and promising upcoming research openings for developing TMDs-based electrodes for RBs are discussed.

2D MXenes Nanosheets for Advanced Energy Conversion and Storage Devices: Recent Advances and Future Prospects.

Since the initial MXenes were discovered in 2011, several MXene compositions constructed using combinations of various transition metals have been developed. MXenes are ideal candidates for different applications in energy conversion and storage, because of their unique and interesting characteristics, which included good electrical conductivity, hydrophilicity, and simplicity of large-scale synthesis. Herein, we study the current developments in two-dimensional (2D) MXene nanosheets for energy storage and conversion technologies. First, we discuss the introduction to energy storage and conversion devices. Later, we emphasized on 2D MXenes and some specific properties of MXenes. Subsequently, research advances in MXene-based electrode materials for energy storage such as supercapacitors and rechargeable batteries is summarized. We provide the relevant energy storage processes, common challenges, and potential approaches to an acceptable solution for 2D MXene-based energy storage. In addition, recent advances for MXenes used in energy conversion devices like solar cells, fuel cells and catalysis is also summarized. Finally, the future prospective of growing MXene-based energy conversion and storage are highlighted.

Recent Advances in Bioactive Carbon Nanotubes Based on Polymer Composites for Biosensor Applications.

Recent breakthroughs in the field of carbon nanotubes (CNTs) have opened up unprecedented opportunities for the development of specialized bioactive CNT-polymers for a variety of biosensor applications. The incorporation of bioactive materials, including DNA, aptamers and antibodies, into CNTs to produce composites of bioactive CNTs has attracted considerable attention. In addition, polymers are essential for the development of biosensors as they provide biocompatible conditions and are the ideal matrix for the immobilization of proteins. The numerous applications of bioactive compounds combined with the excellent chemical and physical properties of CNTs have led to the development of bioactive CNT-polymer composites. This article provides a comprehensive overview of CNT-polymer composites and new approaches to encapsulate bioactive compounds and polymers in CNTs. Finally, biosensor applications of bioactive CNT-polymer for the detection of glucose, H2O2 and cholesterol were investigated. The surface of CNT-polymer facilitates the immobilization of bioactive molecules such as DNA, enzymes or antibodies, which in turn enables the construction of state-of-the-art, future-oriented biosensors.

Assessment of heavy metals accumulation by vegetables irrigated with different stages of textile wastewater for evaluation of food and health risk.

Wastewater irrigation for vegetable cultivation is greatly concerned about the presence of toxic metals in irrigated soil and vegetables which causes possible threats to human health. This study aimed to ascertain the accumulation of heavy metals (HMs) in edible parts of vegetables irrigated with different stages of textile dyeing wastewater (TDW). Bio-concentration factor (BCF), Estimated daily intake (EDI), and target hazard quotient (THQ) were computed to estimate human health risks and speculate the hazard index (HI) of adults and children with the consumption of HMs contaminated vegetables at recommended doses. Five vegetables (red amaranth, Indian spinach, cauliflower, tomato, and radish) in a pot experiment were irrigated with groundwater (T1) and seven stages of TDW (T2∼T8) following a randomized complete block design (RCBD) with three replications. Among the TDW stages, T8, T7, T4, and T5 exhibited elevated BCF, EDI, THQ, and HI due to a rising trend in the accumulation of Pb, Cd, Cr, and Ni heavy metals in the edible portion of the red amaranth, followed by radish, Indian spinach, cauliflower, and tomato. The general patterns of heavy metal (HM) accumulation, regarded as vital nutrients for plants, were detected in the following sequence: Zn > Mn/Cu > Fe. Conversely, toxic metals were found to be Cd/Cr > Ni > Pb, regardless of the type of vegetables. Principal Component Analysis (PCA) identified T8, T7, and T4 of TDW as the primary contributors to the accumulation of heavy metals in the vegetables examined. Furthermore, the analysis of the heavy metals revealed that the BCF, THQ, and HI values for all studied metals were below 1, except for Pb. This suggests that the present consumption rates of different leafy and non-leafy vegetables, whether consumed individually or together, provide a low risk in terms of heavy metal exposure. Nevertheless, the consumption of T8, T7, and T4 irrigated vegetables, specifically Indian spinach alone or in combination with red amaranth and radish, by both adults and children, at the recommended rate, was found to pose potential health risks. On the other hand, T2, T3, and T6 irrigated vegetables were deemed safe for consumption. These findings indicated that the practice of irrigating the vegetables with T8, T7, and T4 stages of TDW has resulted in a significant buildup of heavy metals in the soils and edible parts of vegetables which are posing health risks to adults and children. Hence, it is imperative to discharge the T8, T7, and T4 stages of TDW after ETP to prevent the contamination of vegetables and mitigate potential health risks.

Microenvironmental autophagy promotes tumour growth.

As malignant tumours develop, they interact intimately with their microenvironment and can activate autophagy, a catabolic process which provides nutrients during starvation. How tumours regulate autophagy in vivo and whether autophagy affects tumour growth is controversial. Here we demonstrate, using a well characterized Drosophila melanogaster malignant tumour model, that non-cell-autonomous autophagy is induced both in the tumour microenvironment and systemically in distant tissues. Tumour growth can be pharmacologically restrained using autophagy inhibitors, and early-stage tumour growth and invasion are genetically dependent on autophagy within the local tumour microenvironment. Induction of autophagy is mediated by Drosophila tumour necrosis factor and interleukin-6-like signalling from metabolically stressed tumour cells, whereas tumour growth depends on active amino acid transport. We show that dormant growth-impaired tumours from autophagy-deficient animals reactivate tumorous growth when transplanted into autophagy-proficient hosts. We conclude that transformed cells engage surrounding normal cells as active and essential microenvironmental contributors to early tumour growth through nutrient-generating autophagy.

Nanotechnology-Based Strategies for Extended-Release Delivery of Angiotensin Receptor Blockers (ARBs): A Comprehensive Review.

There has been a significant shift in the perception of hypertension as an important contributor to the global disease burden. Approximately 6 % and 8 % of pregnancies are affected by hypertension, which can adversely affect the mother and the fetus. Furthermore, a hypertensive individual is at increased risk of developing kidney disease, arterial hardening, eye damage, and strokes. Using angiotensin receptor blockers (ARBs) is widespread in treating hypertension, heart failure, coronary artery disease, and diabetic nephropathy. Despite this, some ARBs have limited use due to their poor oral bioavailability and water solubility. To tackle this, a variety of nanoparticle (NP)-based systems, such as polymeric NPs (i. e., dendrimers), polymeric micelles, polymer-drug conjugates, lipid NPs, nanoemulsions, self-emulsifying drug delivery systems (SEDDS), solid lipid NPs (SLNs), nanostructured lipid carriers (NLCs), carbon-based nanocarriers, inorganic NPs, and nanocrystals, have been recently developed for efficient delivery of losartan, Valsartan (Val), Olmesartan (OLM), Telmisartan (TEL), Candesartan, Eprosartan, Irbesartan, and Azilsartan to target cells. This review article provides a literature-based comparison of the various classes of ARBs, their mechanisms of action, and an overview of the nanoformulations developed for ARB delivery and successfully applied to managing hypertension, diabetic complications, and other conditions.

Metal-Organic Frameworks Derived Electrocatalysts for Oxygen and Carbon Dioxide Reduction Reaction.

The increasing demands of energy and environmental concerns have motivated researchers to cultivate renewable energy resources for replacing conventional fossil fuels. The modern energy conversion and storage devices required high efficient and stable electrocatalysts to fulfil the market demands. In previous years, we are witness for considerable developments of scientific attention in Metal-organic Frameworks (MOFs) and their derived nanomaterials in electrocatalysis. In current review article, we have discussed the progress of optimistic strategies and approaches for the manufacturing of MOF-derived functional materials and their presentation as electrocatalysts for significant energy related reactions. MOFs functioning as a self-sacrificing template bid different benefits for the preparation of metal nanostructures, metal oxides and carbon-abundant materials promoting through the porous structure, organic functionalities, abundance of metal sites and large surface area. Thorough study for the recent advancement in the MOF-derived materials, metal-coordinated N-doped carbons with single-atom active sites are emerging candidates for future commercial applications. However, there are some tasks that should be addressed, to attain improved, appreciative and controlled structural parameters for catalytic and chemical behavior.

Non-enzymatic electrochemical sensing of dopamine from COVID-19 quarantine person.

The worldwide outbreak of COVID-19 pandemic, is not only a great threat to the victim life but it is leaving invisible devastating negative affect on mental health of quarantined individual because of isolation, depression, bereavement, and loss of income. Therefore, the precise monitoring catecholamine neurotransmitters specifically of dopamine (DA) is of great importance to assess the mental health. Thus, herein we have synthesized Co-based zeolitic imidazolate framework (ZIF-67) through solvothermal method for precise monitoring of DA. To facilitate the fast transportation of ions, highly conductive polymer, poly(3,4-ethylenedioxythiophene; PEDOT) has been integrated on the surface of ZIF-67 which not only provides the smooth pathway for ions/electrons transportation but also saves the electrode from pulverization. The fabricated ZIF-67/PEDOT electrode shows a significant sensing performance towards DA detection in terms of short diffusion pathways by expositing more active sites, over good linear range (15-240 µM) and a low detection limit of (0.04 µM) even in the coexistence of the potentially interfering molecules. The developed ZIF-67/PEDOT sensor was successfully employed for sensitive and selective monitoring of DA from COVID-19 quarantined person blood, thus suggesting reliability of the developed electrode.

Development of a Toxic Lead Ionic Sensor Using Carboxyl-Functionalized MWCNTs in Real Water Sample Analyses.

Functional multiwall carbon nanotubes (f-MWCNTs) are of significant interest due to their dispersion ability in the aqueous phase and potential application in environmental, nanotechnology, and biological fields. Herein, we functionalized MWCNTs by a simple acid treatment under ultra-sonification, which represented a terminal or side-functional improvement for the fabrication of a toxic lead ion sensor. The f-MWCNTs were characterized in detail by XRD, Raman, XPS, BET, UV/vis, FTIR, and FESEM-coupled XEDS techniques. The analytical performance of the f-MWCNTs was studied for the selective detection of toxic lead ions by inductively coupled plasma-optical emission spectrometry (ICP-OES). The selectivity of the f-MWCNTs was evaluated using several metal ions such as Cd2+, Co2+, Cr3+, Cu2+, Fe3+, Ni2+, Pb2+, and Zn2+ ions. Lastly, the newly designed ionic sensor was successfully employed to selectively detect lead ions in several environmental water samples with reasonable results. This approach introduced a new technique for the selective detection of heavy metal ions using functional carbon nanotubes with ICP-OES for the safety of environmental and healthcare fields on a broad scale.

An Electrochemical Approach for the Selective Detection of Cancer Metabolic Creatine Biomarker with Porous Nano-Formulated CMNO Materials Decorated Glassy Carbon Electrode.

The facile wet-chemical technique was used to prepare the low-dimensional nano-formulated porous mixed metal oxide nanomaterials (CuO.Mn2O3.NiO; CMNO NMs) in an alkaline medium at low temperature. Detailed structural, morphological, crystalline, and functional characterization of CMNO NMs were performed by X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-vis), Fourier-transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), and energy-dispersive X-ray spectroscopy (EDS) analyses. An efficient and selective creatine (CA) sensor probe was fabricated by using CMNO NMs decorated onto glassy carbon electrode (GCE) as CMNO NMs/GCE by using Nafion adhesive (5% suspension in ethanol). The relation of current versus the concentration of CA was plotted to draw a calibration curve of the CMNO NMs/GCE sensor probe, which was found to have a very linear value (r2 = 0.9995) over a large dynamic range (LDR: 0.1 nM~0.1 mM) for selective CA detection. The slope of LDR by considering the active surface area of GCE (0.0316 cm2) was applied to estimate the sensor sensitivity (14.6308 µAµM-1 cm-2). Moreover, the detection limit (21.63 ± 0.05 pM) of CMNO MNs modified GCE was calculated from the signal/noise (S/N) ratio at 3. As a CA sensor probe, it exhibited long-term stability, good reproducibility, and fast response time in the detection of CA by electrochemical approach. Therefore, this research technique is introduced as a promising platform to develop an efficient sensor probe for cancer metabolic biomarker by using nano-formulated mixed metal oxides for biochemical as well as biomedical research for the safety of health care fields.

Phenolic sensor development based on chromium oxide-decorated carbon nanotubes for environmental safety.

A nanocomposite (NC) composed of chromium(III)oxide nanomaterials decorated carbon nanotubes (Cr2O3-CNT NC) was prepared via a simple solution method with reducing agents in an alkaline medium. The Cr2O3-CNT NC was characterized using ultraviolet-visible (UV/Vs.) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, energy-dispersive X-ray spectroscopy (XEDS), X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and field-emission scanning electron microscopy (FESEM). The Cr2O3-CNT composite was deposited on a flat glassy carbon electrode (GCE) with conducting nafion (5%) binders to produce a sensor that exhibited fast response and high selectivity toward 4-methoxyphenol (4MP) in phosphate buffer phase at pH 7. Furthermore, the sensor performance parameters, including the sensitivity, lower detection range, reliability, and reproducibility, ease of integration, long-term stability, and selectivity were investigated in detail. The calibration plot was found to be linear in the concentration range of 0.01 nM-0.1 µM. The sensitivity and detection limit were calculated as 1.4768 µA cm-2 µM-1 and 0.06428 ± 0.0002 nM (at a signal-to-noise ratio of 3), respectively. Thus, it was concluded that the proposed selective and efficient sensor represents a promising approach to effectively detect toxic phenolic compounds in the environment with acceptable and reliable results.

Ultrasensitive and selective 4-aminophenol chemical sensor development based on nickel oxide nanoparticles decorated carbon nanotube nanocomposites for green environment.

Nickel oxide nanoparticles decorated carbon nanotube nanocomposites (NiO·CNT NCs) were prepared in a basic medium by using facile wet-chemical routes. The optical, morphological, and structural properties of NiO·CNT NCs were characterized using Fourier transformed infra-red (FT-IR), Ultra-violet visible (UV/Vis) spectroscopy, field-emission scanning electron microscopy (FESEM), X-ray energy dispersed spectroscopy (XEDS), X-ray photoelectron spectroscopy (XPS), and powder X-ray diffraction (XRD) methods. Selective 4-aminophenol (4-AP) chemical sensor was developed by a flat glassy carbon electrode (GCE, surface area: 0.0316cm2) fabricated with a thin-layer of NCs. Electrochemical responses including higher sensitivity, large dynamic range (LDR), limit of detection (LOD), and long-term stability towards 4-AP were obtained using the fabricated chemical sensors. The calibration curve was found linear (R2=0.914) over a wide range of 4-AP concentration (0.1nmol/L-0.1mol/L). In perspective of slope (2×10-5µA/µM), LOD and sensitivity were calculated as 15.0±0.1pM and ~6.33×10-4µA/(µM·cm) respectively. The synthesized NiO·CNT NCs using a wet-chemical method is a significant route for the development of ultrasensitive and selective phenolic sensor based on nano-materials for environmental toxic substances. It is suggested that a pioneer and selective development of 4-AP sensitive sensor using NiO·CNT NCs by a facile and reliable current vs voltage (I-V) method for the major application of toxic agents in biological, green environmental, and health-care fields in near future.

Silica-gel Particles Loaded with an Ionic Liquid for Separation of Zr(IV) Prior to Its Determination by ICP-OES.

A new ionic liquid loaded silica gel amine (SG-APTMS-N,N-EPANTf2) was developed, as an adsorptive material, for selective adsorption and determination of zirconium, Zr(IV), without the need for a chelating intermediate. Based on a selectivity study, the SG-APTMS-N,N-EPANTf2 phase showed a perfect selectivity towards Zr(IV) at pH 4 as compared to other metallic ions, including gold [Au(III)], copper [Cu(II)], cobalt [Co(II)], chromium [Cr(III)], lead [Pb(II)], selenium [Se(IV)] and mercury [Hg(II)] ions. The influence of pH, Zr(IV) concentration, contact time and interfering ions on SG-APTMS-N,N-EPANTf2 uptake for Zr(IV) was evaluated. The presence of incorporated donor atoms in newly synthesized SG-APTMS-N,N-EPANTf2 phase played a significant role in enhancing its uptake capacity of Zr(IV) by 78.64% in contrast to silica gel (activated). The equilibrium and kinetic information of Zr(IV) adsorption onto SG-APTMS-N,N-EPANTf2 were best expressed by Langmuir and pseudo second-order kinetic models, respectively. General co-existing cations did not interfere with the extraction and detection of Zr(IV). Finally, the analytical efficiency of the newly developed method was also confirmed by implementing it for the determination of Zr(IV) in several water samples.

Development of penicillin G biosensor based on penicillinase enzymes immobilized onto bio-chips.

Penicillin G (Pen-G) biosensor was developed by immobilizing penicillinase enzymes (Pen-X) onto tiny bio-chips using thioglycolic acid self-assembled monolayer (TGA-SAM). The selective pen-G biosensor was investigated by ferri/ferrocyanide couple using electrochemical method for catalytic hydrolysis of Pen-G/Pen-X in a very sensible approach. Pen-G was detected with modified bio-chip (Gold electrode of bio-chip/Thioglycolic acid/Penicillinase enzyme, in shortly AuE/TGA/Pen-X) by reliable cyclic voltammetric method at pH 7.1 in room conditions. The AuE/TGA/Pen-X modified bio-chip sensor demonstrates good linearity (50.0 nM to 5.0 mM; R = 0.9987), low-detection limit (~1.26 nM, SNR ~ 3), and higher sensitivity (~4.97 µA.µM(-1).cm(-2)), lowest-small sample volume (<70.0 µL), good stability, selectivity, and reproducibility. To the best of our knowledge, this is the first statement in which such a very high sensitivity, low-detection limit, and low-sample volume are required for Pen-G biosensor using AuE/TGA/Pen-X bio-chips assembly. The results of these studies have introduced for biomedical applications with interesting assembly (AuE/TGA/Pen-X) towards the development of selective Pen-G biosensors. The AuE/TGA-SAM system was implemented a facile approach to the integration of Pen-X/Pen-G fabricated bio-chips, which can offer analytical access to a large group of enzymes for wide range of biomedical applications in health-care fields.