Detalhe da pesquisa
1.
Pharmacokinetics and safety of sacubitril/valsartan (LCZ696) in patients with mild and moderate hepatic impairmentâ©.
Int J Clin Pharmacol Ther
; 55(9): 728-739, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28737127
2.
The effect of LCZ696 (sacubitril/valsartan) on amyloid-ß concentrations in cerebrospinal fluid in healthy subjects.
Br J Clin Pharmacol
; 81(5): 878-90, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26663387
3.
Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization.
Eur J Clin Pharmacol
; 72(8): 917-24, 2016 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-27083930
4.
Effect of renal function on the pharmacokinetics of LCZ696 (sacubitril/valsartan), an angiotensin receptor neprilysin inhibitor.
Eur J Clin Pharmacol
; 72(9): 1065-73, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27230850
5.
Effect of food on the oral bioavailability of the angiotensin receptor - neprilysin inhibitor sacubitril/valsartan (LCZ696) in healthy subjectsâ©.
Int J Clin Pharmacol Ther
; 54(12): 1012-1018, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27719743
6.
Pharmacokinetics of serelaxin in patients with hepatic impairment: a single-dose, open-label, parallel group study.
Br J Clin Pharmacol
; 79(6): 937-45, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25511105
7.
Cytochrome P450 2C19*2 polymorphism in patients with stable coronary heart disease and risk for secondary cardiovascular disease events: results of a long-term follow-up study in routine clinical care.
BMC Cardiovasc Disord
; 13: 61, 2013 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23981380
8.
Genetic Diversity in Drug Transporters: Impact in African Populations.
Clin Transl Sci
; 13(5): 848-860, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32100958
9.
New paradigm for expediting drug development in Asia.
Drug Discov Today
; 25(3): 491-496, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31926136
10.
PK/PD modelling and simulations: utility in drug development.
Drug Discov Today
; 13(7-8): 341-6, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18405847
11.
African Genetic Diversity: Implications for Cytochrome P450-mediated Drug Metabolism and Drug Development.
EBioMedicine
; 17: 67-74, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-28237373
12.
Assessment of Drug-Drug Interaction Potential Between Atorvastatin and LCZ696, A Novel Angiotensin Receptor Neprilysin Inhibitor, in Healthy Chinese Male Subjects.
Eur J Drug Metab Pharmacokinet
; 42(2): 309-318, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-27245340
13.
Effects of age and sex on the pharmacokinetics of LCZ696, an angiotensin receptor neprilysin inhibitor.
J Clin Pharmacol
; 56(1): 78-86, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26073563
14.
Pharmacodynamic and Pharmacokinetic Profiles of Sacubitril/Valsartan (LCZ696) in Patients with Heart Failure and Reduced Ejection Fraction.
Cardiovasc Ther
; 34(4): 191-8, 2016 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26990595
15.
Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects.
Clin Pharmacol Drug Dev
; 5(1): 27-39, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27119576
16.
Pergolide: multiple-dose pharmacokinetics in patients with mild to moderate Parkinson disease.
Clin Neuropharmacol
; 28(3): 120-5, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15965310
17.
Serial measurements of N-terminal pro-brain natriuretic peptide in patients with coronary heart disease.
PLoS One
; 10(1): e0117143, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25629613
18.
Pharmacokinetic drug-drug interaction assessment between LCZ696, an angiotensin receptor neprilysin inhibitor, and hydrochlorothiazide, amlodipine, or carvedilol.
Clin Pharmacol Drug Dev
; 4(6): 407-17, 2015 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27137712
19.
Safety and tolerability of serelaxin, a recombinant human relaxin-2 in development for the treatment of acute heart failure, in healthy Japanese volunteers and a comparison of pharmacokinetics and pharmacodynamics in healthy Japanese and Caucasian populations.
J Clin Pharmacol
; 55(4): 415-22, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25408331
20.
Evaluation of methods for improving precision of blood pressure measurements in phase I clinical trials.
J Clin Pharmacol
; 44(5): 457-63, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15102865