Detalhe da pesquisa
1.
Continuous-flow injection microfluidic thrombin assays: The effect of binding kinetics on observed enzyme inhibition.
Anal Biochem
; 528: 38-46, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28456636
2.
Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome.
J Med Chem
; 62(20): 9246-9253, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31560200
3.
Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform.
J Med Chem
; 61(10): 4335-4347, 2018 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29701962
4.
Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery.
Biochem J
; 399(1): 47-57, 2006 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16776649
5.
The background, discovery and clinical development of BCR-ABL inhibitors.
Drug Discov Today
; 18(19-20): 992-1000, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23769978
6.
Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery.
ACS Med Chem Lett
; 4(8): 768-72, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900744
7.
Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform.
J Med Chem
; 56(7): 3033-47, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23441572
8.
cis-6-oxo-hexahydro-2-oxa-1,4-diazapentalene and cis-6-oxo-hexahydropyrrolo[3,2-c]pyrazole based scaffolds: design rationale, synthesis and cysteinyl proteinase inhibition.
Bioorg Med Chem Lett
; 15(5): 1327-31, 2005 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15713380
9.
A single-step method for the production of sugar hydrazides: intermediates for the chemoselective preparation of glycoconjugates.
Bioconjug Chem
; 16(3): 722-8, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15898743
10.
Synthesis and evaluation of cis-hexahydropyrrolo[3,2-b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases.
Bioorg Med Chem
; 13(3): 609-25, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15653329
11.
Novel chemoselective linkage chemistry toward controlled loading of ligands to proteins through in situ real-time quantification of conjugate formation.
Bioconjug Chem
; 15(5): 1010-20, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15366954
12.
Bicyclic peptidomimetic tetrahydrofuro[3,2-b]pyrrol-3-one and hexahydrofuro[3,2-b]pyridine-3-one based scaffolds: synthesis and cysteinyl proteinase inhibition.
Bioorg Med Chem
; 12(21): 5689-710, 2004 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15465346
13.
Functionalised 2,3-dimethyl-3-aminotetrahydrofuran-4-one and N-(3-oxo-hexahydrocyclopenta[b]furan-3a-yl)acylamide based scaffolds: synthesis and cysteinyl proteinase inhibition.
Bioorg Med Chem
; 12(11): 2903-25, 2004 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15142551