Detalhe da pesquisa
1.
Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop.
J Biol Chem
; 291(4): 1854-1865, 2016 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26627831
2.
The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.
Proteomics
; 15(2-3): 447-61, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25330774
3.
The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.
Pflugers Arch
; 467(8): 1783-94, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25277268
4.
Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells.
bioRxiv
; 2024 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38496440
5.
Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.
J Biol Chem
; 287(44): 36639-49, 2012 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22942289
6.
Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator.
iScience
; 24(6): 102542, 2021 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34142049
7.
A chemical corrector modifies the channel function of F508del-CFTR.
Mol Pharmacol
; 78(3): 411-8, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20501743
8.
Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease.
Biochem J
; 418(1): 185-90, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18945216
9.
A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stability.
Mol Pharmacol
; 75(6): 1430-8, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339490
10.
The intact CFTR protein mediates ATPase rather than adenylate kinase activity.
Biochem J
; 412(2): 315-21, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18241200
11.
Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
Cells
; 8(8)2019 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31370288
12.
The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1-NBD2 heterodimer.
Biochem J
; 401(2): 581-6, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16989640
13.
Evaluation of the membrane-spanning domain of ClC-2.
Biochem J
; 396(3): 449-60, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16526942
14.
Nucleotides bind to the C-terminus of ClC-5.
Biochem J
; 398(2): 289-94, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16686597
15.
Dimeric cystic fibrosis transmembrane conductance regulator exists in the plasma membrane.
Biochem J
; 374(Pt 3): 793-7, 2003 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12820897
16.
Stable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective pore.
Biochem J
; 375(Pt 3): 633-41, 2003 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12892562
17.
ATPase assay of purified, reconstituted CFTR protein.
J Cyst Fibros
; 3 Suppl 2: 133-4, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15463945
18.
Methods to study CFTR protein in vitro.
J Cyst Fibros
; 3 Suppl 2: 79-83, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15463933
19.
Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods.
J Cyst Fibros
; 3 Suppl 2: 119-21, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15463942
20.
The patch-clamp and planar lipid bilayer techniques: powerful and versatile tools to investigate the CFTR Cl- channel.
J Cyst Fibros
; 3 Suppl 2: 101-8, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15463939