Detalhe da pesquisa
1.
Sorafenib plus intensive chemotherapy in newly diagnosed FLT3-ITD AML: a randomized, placebo-controlled study by the ALLG.
Blood
; 142(23): 1960-1971, 2023 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37647654
2.
Expanding the π-system of fatty acid-anion transporter conjugates modulates their mechanism of proton transport and mitochondrial uncoupling activity.
Chemistry
; : e202400931, 2024 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38838073
3.
N,N'-Dimethylsquaramide as a central scaffold for anionophore design.
Org Biomol Chem
; 22(24): 4868-4876, 2024 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38764358
4.
4-Chloroisocoumarins as Chlamydial Protease Inhibitors and Anti-Chlamydial Agents.
Molecules
; 29(7)2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38611800
5.
The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavity.
J Biol Chem
; 296: 100282, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33450225
6.
Peripheral Administration of Selective Glycine Transporter-2 Inhibitor, Oleoyl-D-Lysine, Reverses Chronic Neuropathic Pain but Not Acute or Inflammatory Pain in Male Mice.
J Pharmacol Exp Ther
; 382(3): 246-255, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35779948
7.
Protonophoric and mitochondrial uncoupling activity of aryl-carbamate substituted fatty acids.
Org Biomol Chem
; 21(1): 132-139, 2022 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36453203
8.
l-3,4-dihydroxyphenylalanine (l-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease.
J Neurochem
; 150(1): 88-106, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30716176
9.
A novel synthetic analogue of ω-3 17,18-epoxyeicosatetraenoic acid activates TNF receptor-1/ASK1/JNK signaling to promote apoptosis in human breast cancer cells.
FASEB J
; 31(12): 5246-5257, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28798154
10.
Cytochrome P450-Mediated Biotransformation of Sorafenib and Its N-Oxide Metabolite: Implications for Cell Viability and Human Toxicity.
Chem Res Toxicol
; 28(1): 92-102, 2015 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25489883
11.
Selective inhibition of human solute carrier transporters by multikinase inhibitors.
Drug Metab Dispos
; 42(11): 1851-7, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25165131
12.
Effects of cationic head group structure on cytotoxicity and mitochondrial actions of amphiphilic ionic liquids.
Food Chem Toxicol
; 183: 114202, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38007213
13.
Cytotoxicity of acridinium-based ionic liquids: Structure-activity relationship and mechanistic studies.
Chem Biol Interact
; 396: 111042, 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38735455
14.
The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU.
Int J Biochem Cell Biol
; 171: 106571, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38608921
15.
The Role of Autophagy in Human Uveal Melanoma and the Development of Potential Disease Biomarkers and Novel Therapeutic Paradigms.
Biomedicines
; 12(2)2024 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38398064
16.
Cell-derived microparticles: new targets in the therapeutic management of disease.
J Pharm Pharm Sci
; 16(2): 238-53, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23958193
17.
Fatty Acid-Activated Proton Transport by Bisaryl Anion Transporters Depolarises Mitochondria and Reduces the Viability of MDA-MB-231 Breast Cancer Cells.
Biomolecules
; 13(8)2023 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37627266
18.
Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2.
ACS Chem Neurosci
; 14(15): 2634-2647, 2023 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37466545
19.
Inclusion of the in-chain sulfur in 3-thiaCTU increases the efficiency of mitochondrial targeting and cell killing by anticancer aryl-urea fatty acids.
Eur J Pharmacol
; 939: 175470, 2023 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36543287
20.
An update on inflammation in uveal melanoma.
Biochimie
; 212: 114-122, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37105300