Detalhe da pesquisa
1.
High-resolution structure and strain comparison of infectious mammalian prions.
Mol Cell
; 81(21): 4540-4551.e6, 2021 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34433091
2.
Cryo-EM of prion strains from the same genotype of host identifies conformational determinants.
PLoS Pathog
; 18(11): e1010947, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36342968
3.
Domain-specific Quantification of Prion Protein in Cerebrospinal Fluid by Targeted Mass Spectrometry.
Mol Cell Proteomics
; 18(12): 2388-2400, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31558565
4.
Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates.
PLoS Pathog
; 13(9): e1006623, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28910420
5.
PrP P102L and Nearby Lysine Mutations Promote Spontaneous In Vitro Formation of Transmissible Prions.
J Virol
; 91(21)2017 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28835493
6.
PrPSc-Specific Antibody Reveals C-Terminal Conformational Differences between Prion Strains.
J Virol
; 90(10): 4905-4913, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26937029
7.
Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins.
J Virol
; 86(21): 11763-78, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22915801
8.
Time course of prion seeding activity in cerebrospinal fluid of scrapie-infected hamsters after intratongue and intracerebral inoculations.
J Clin Microbiol
; 50(4): 1464-6, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22238438
9.
Cryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains.
Nat Commun
; 13(1): 4005, 2022 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35831291
10.
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra.
Biochemistry
; 50(21): 4479-90, 2011 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-21539311
11.
Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors.
J Biol Chem
; 285(19): 14083-7, 2010 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20304915
12.
The most infectious prion protein particles.
Nature
; 437(7056): 257-61, 2005 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-16148934
13.
Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.
Proc Natl Acad Sci U S A
; 105(36): 13626-31, 2008 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18757733
14.
Transmission of CJD from nasal brushings but not spinal fluid or RT-QuIC product.
Ann Clin Transl Neurol
; 7(6): 932-944, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32538552
15.
Antisense oligonucleotides extend survival of prion-infected mice.
JCI Insight
; 52019 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31361599
16.
Publisher Correction: Early preclinical detection of prions in the skin of prion-infected animals.
Nat Commun
; 10(1): 640, 2019 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30718499
17.
Early preclinical detection of prions in the skin of prion-infected animals.
Nat Commun
; 10(1): 247, 2019 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30651538
18.
Immunodetection of PrPSc Using Western Immunoblotting Techniques.
Methods Mol Biol
; 1658: 51-66, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28861782
19.
RT-QuIC Assays for Prion Disease Detection and Diagnostics.
Methods Mol Biol
; 1658: 185-203, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28861791
20.
Amplified Detection of Prions and Other Amyloids by RT-QuIC in Diagnostics and the Evaluation of Therapeutics and Disinfectants.
Prog Mol Biol Transl Sci
; 150: 375-388, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28838670