Detalhe da pesquisa
1.
A Dynamic and Combinatorial Histone Code Drives Malaria Parasite Asexual and Sexual Development.
Mol Cell Proteomics
; 21(3): 100199, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35051657
2.
New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic Acid Derivatives.
Chembiochem
; 23(21): e202200427, 2022 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36106425
3.
The ecdysone receptor regulates several key physiological factors in Anopheles funestus.
Malar J
; 21(1): 97, 2022 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35305668
4.
Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation.
BMC Genomics
; 20(1): 920, 2019 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31795940
5.
Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.
Antimicrob Agents Chemother
; 62(8)2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29866868
6.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
7.
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.
J Antimicrob Chemother
; 73(5): 1279-1290, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420756
8.
Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.
Malar J
; 14: 213, 2015 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25994518
9.
Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.
Bioorg Med Chem
; 23(16): 5131-43, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25684422
10.
Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs.
Antimicrob Agents Chemother
; 58(5): 2586-97, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24550329
11.
Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration.
Eur J Med Chem
; 271: 116429, 2024 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38663284
12.
Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites.
Antimicrob Agents Chemother
; 57(6): 2874-7, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23545535
13.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
14.
Streamlined and Robust Stage-Specific Profiling of Gametocytocidal Compounds Against Plasmodium falciparum.
Front Cell Infect Microbiol
; 12: 926460, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35846744
15.
Adapt or Die: Targeting Unique Transmission-Stage Biology for Malaria Elimination.
Front Cell Infect Microbiol
; 12: 901971, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35755845
16.
Adsorption to the Surface of Hemozoin Crystals: Structure-Based Design and Synthesis of Amino-Phenoxazine ß-Hematin Inhibitors.
ChemMedChem
; 17(10): e202200139, 2022 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35385211
17.
In vitro dual activity of Aloe marlothii roots and its chemical constituents against Plasmodium falciparum asexual and sexual stage parasites.
J Ethnopharmacol
; 297: 115551, 2022 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35850311
18.
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model.
J Med Chem
; 65(24): 16695-16715, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36507890
19.
Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer.
Front Pharmacol
; 13: 875647, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35600849
20.
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages.
Sci Transl Med
; 14(667): eabo7219, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36260689