Detalhe da pesquisa
1.
In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment.
Antimicrob Agents Chemother
; 59(9): 5664-74, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26149995
2.
Whole cell screen based identification of spiropiperidines with potent antitubercular properties.
Bioorg Med Chem Lett
; 25(16): 3234-45, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26087937
3.
1,4-azaindole, a potential drug candidate for treatment of tuberculosis.
Antimicrob Agents Chemother
; 58(9): 5325-31, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24957839
4.
Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: structure-activity relationship and in vivo efficacy in a mouse model of tuberculosis.
Antimicrob Agents Chemother
; 58(1): 61-70, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24126580
5.
In vitro and in vivo efficacy of ß-lactams against replicating and slowly growing/nonreplicating Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 57(6): 2506-10, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23507276
6.
Effect of coadministration of moxifloxacin and rifampin on Mycobacterium tuberculosis in a murine aerosol infection model.
Antimicrob Agents Chemother
; 56(6): 3054-7, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22470118
7.
Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis.
J Med Chem
; 60(4): 1379-1399, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28075132
8.
Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.
Nat Commun
; 6: 6715, 2015 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25823686
9.
Benzimidazoles: novel mycobacterial gyrase inhibitors from scaffold morphing.
ACS Med Chem Lett
; 5(7): 820-5, 2014 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25050172
10.
Pharmacokinetics and dose response of anti-TB drugs in rat infection model of tuberculosis.
Tuberculosis (Edinb)
; 94(3): 282-6, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24629633
11.
Lead optimization of 1,4-azaindoles as antimycobacterial agents.
J Med Chem
; 57(13): 5728-37, 2014 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24874895
12.
Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against Mycobacterium tuberculosis.
J Med Chem
; 57(11): 4889-905, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24809953
13.
N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds.
J Med Chem
; 57(15): 6642-52, 2014 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25007124
14.
4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity.
J Med Chem
; 57(12): 5419-34, 2014 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24871036
15.
Effect of repeated dosing on rifampin exposure in BALB/c mice.
Eur J Pharm Sci
; 49(1): 33-8, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23395915
16.
Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA Gyrase B.
J Med Chem
; 56(21): 8834-48, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24088190
17.
Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.
J Med Chem
; 56(23): 9701-8, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24215368
18.
Fast mouse PK (Fast PK): a rapid screening method to increase pharmacokinetic throughput in pre-clinical drug discovery.
Eur J Pharm Sci
; 47(2): 444-50, 2012 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22789493