RESUMO
BACKGROUND: Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. RESULTS: In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts. CONCLUSIONS: In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.
Assuntos
Genética Populacional , Adulto , Idoso , Feminino , Dosagem de Genes/genética , Frequência do Gene , Variação Genética , Haplótipos , Humanos , Desequilíbrio de Ligação , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , EspanhaRESUMO
Se realizó una estrategia de intervención en salud en 30 estudiantes entre 16 y 18 años de edad, quienes presentaban conductas inapropiadas, pertenecientes al Instituto Preuniversitario "Alfredo Guillot Pozo" de Santiago de Cuba, con vistas a mejorar su comportamiento. Se llevaron a cabo acciones educativas que incluyeron: tratamiento terapéutico por parte del equipo de salud, recursos educativos y actividades psicoterapéuticas, donde también participaron familiares, profesores y directivos de las organizaciones de masas. En la serie predominaron el sexo masculino, los adolescentes procedentes de familias disfuncionales y la mala relación hogar-escuela. El aporte del trabajador social junto al médico de la familia, fue valioso para lograr el enfoque integral del adolescente en su medio familiar, escolar y social.
A health intervention strategy in 30 students aged 16 to 18 who presented inappropriate behaviors, belonging to "Alfredo Guillot Pozo" senior high school in Santiago de Cuba, was carried out with the purpose of improving their behavior. Some educational actions were carried out such as: therapeutic treatment by the health team, educational resources and psychotherapeutic activities, where relatives, professors and mass organizations managers also participated. The male sex, adolescents coming from dysfunctional families and home-school poor relationship prevailed in the series. The social worker's contribution along with the family physician was valuable to achieve the adolescent's comprehensive focusing in his family, school and social environment.