Tracking contaminants in groundwater flowing across a river bottom within a complex karst system: Clues from hydrochemistry, stable isotopes, and tracer tests.

Tracking contaminants in karst aquifers is challenging because of the high heterogeneity encountered in carbonate rocks. Multi-tracer tests, combined with chemical and isotopic analyses, were conducted to solve a groundwater contamination incident within a complex karst aquifer in Southwest China. Results showed that: (1) the wastewater from a paper mill, public sewers, and septic tanks were the three main potential contaminant sources identified by chemical and isotopic methods; (2) a direct effect of the paper mill wastewater with high Na+ (up to 2230.5 mg/L) and chemical oxygen demand (COD) concentrations on spring water quality was confirmed by multi-tracer tests, which changed the water type from Ca-HCO3 in the 1970s to Ca-Na-HCO3 in the present study and resulted in a depleted carbon isotope value (-16.5‰); and (3) the studied aquifer is a highly complex karst system, due to two conduits crossed each other without mixing, contaminants traveled a long distance (up to 14 km) within the lower conduit, paper mill-contaminated groundwater flowed across a river bottom and discharged to the opposite bank, and an active subsurface divide occurred. After several months of operation, the groundwater restoration measure based on karst hydrogeologic conditions proved that cutting off contaminant sources for karst aquifer self-restore was effective in practice, which contributed to the decline in NH4+ (from 7.81 mg/L to 0.04 mg/L), Na+ (from 50.12 mg/L to 4.78 mg/L), and COD (from 16.42 mg/L to 0.9 mg/L) concentrations coupled with an increase in δ13C-DIC value (from -16.5‰ to -8.4‰) in the earlier contaminated karst spring. This study's integrated method is expected to screen and confirm contaminant sources within complex karst systems rapidly and effectively, thereby contributing to karst groundwater environmental management.

The emerging role of pyroptosis-related inflammasome pathway in atherosclerosis.

Atherosclerosis (AS), a chronic sterile inflammatory disorder, is one of the leading causes of mortality worldwide. The dysfunction and unnatural death of plaque cells, including vascular endothelial cells (VEC), macrophages, and vascular smooth muscle cells (VSMC), are crucial factors in the progression of AS. Pyroptosis was described as a form of cell death at least two decades ago. It is featured by plasma membrane swelling and rupture, cell lysis, and consequent robust release of cytosolic contents and pro-inflammatory mediators, including interleukin-1ß (IL-1ß), IL-18, and high mobility group box 1 (HMGB1). Pyroptosis of plaque cells is commonly observed in the initiation and development of AS, and the levels of pyroptosis-related proteins are positively correlated with plaque instability, indicating the crucial contribution of pyroptosis to atherogenesis. Furthermore, studies have also identified some candidate anti-atherogenic agents targeting plaque cell pyroptosis. Herein, we summarize the research progress in understating (1) the discovery and definition of pyroptosis; (2) the characterization and molecular mechanisms of pyroptosis; (3) the regulatory mechanisms of pyroptosis in VEC, macrophage, and VSMC, as well as their potential role in AS progression, aimed at providing therapeutic targets for the prevention and treatment of AS.

Controllable Orientation Growth of ZSM-5 for Methanol to Hydrocarbon Conversion: Cooperative Effects of Seed Induction and Medium pH Control.

The growth orientation of ZSM-5 zeolites strongly affects product selectivity in methanol conversion reaction. Here, we proposed a versatile synthetic strategy by introducing seeds and controlling medium pH to achieve controllable orientation growth of ZSM-5. The systematic analysis of the crystallization process indicated that the introduction of seeds ensured successful crystallization in a quasi-neutral solution and the dissolution rate of seeds and aluminosilicate determined the growth orientation of ZSM-5. In the quasi-neutral solution, the slow dissolution of seeds and aluminosilicate enhanced growth advantages along the c axis. The ratio between the length of the c axis and b axis (Lc/Lb) of the obtained ZSM-5 at pH of 7 could reach 8.1, much higher than 1.8 obtained at pH of 11. No obvious impact of seed added amount on growth orientation was found, while with increasing seed crystal size, the obtained ZSM-5 showed preferred growth along the c axis. The Lc/Lb of the sample adding seeds with a size of 355 nm reached 7.9, much higher than 2.1 of the sample adding seeds with a size of 70 nm. The obtained ZSM-5 with specific growth orientation exhibited potential shape selectivity in methanol to aromatics and olefin reaction. This work opens new possibilities to tailor the orientation growth of ZSM-5 based on the seed-induced strategy under mild conditions.

CdS Nanocubes Adorned by Graphitic C3N4 Nanoparticles for Hydrogenating Nitroaromatics: A Route of Visible-Light-Induced Heterogeneous Hollow Structural Photocatalysis.

Modulating the transport route of photogenerated carriers on hollow cadmium sulfide without changing its intrinsic structure remains fascinating and challenging. In this work, a series of well-defined heterogeneous hollow structural materials consisting of CdS hollow nanocubes (CdS NCs) and graphitic C3N4 nanoparticles (CN NPs) were strategically designed and fabricated according to an electrostatic interaction approach. It was found that such CN NPs/CdS NCs still retained the hollow structure after CN NP adorning and demonstrated versatile and remarkably boosted photoreduction performance. Specifically, under visible light irradiation (λ ≥ 420 nm), the hydrogenation ratio over 2CN NPs/CdS NCs (the mass ratio of CN NPs to CdS NCs is controlled to be 2%) toward nitrobenzene, p-nitroaniline, p-nitrotoluene, p-nitrophenol, and p-nitrochlorobenzene can be increased to 100%, 99.9%, 83.2%, 93.6%, and 98.2%, respectively. In addition, based on the results of photoelectrochemical performances, the 2CN NPs/CdS NCs reach a 0.46% applied bias photo-to-current efficiency, indicating that the combination with CN NPs can indeed improve the migration and motion behavior of photogenerated carriers, besides ameliorating the photocorrosion and prolonging the lifetime of CdS NCs.

Characterization, Classification, and Authentication of Polygonatum sibiricum Samples by Volatile Profiles and Flavor Properties.

The importance of monitoring key aroma compounds as food characteristics to solve sample classification and authentication is increasing. The rhizome of Polygonatum sibiricum (PR, Huangjing in Chinese) has great potential to serve as an ingredient of functional foods owing to its tonic effect and flavor properties. In this study, we aimed to characterize and classify PR samples obtained from different processing levels through their volatile profiles and flavor properties by using electronic nose, electronic tongue, and headspace gas chromatography-mass spectrometry. Nine flavor indicators (four odor indicators and five taste indicators) had a strong influence on the classification ability, and a total of 54 volatile compounds were identified in all samples. The traditional Chinese processing method significantly decreased the contents of aldehydes and alkanes, while more ketones, nitrogen heterocycles, alcohols, terpenoids, sulfides, and furans/pyrans were generated in the processing cycle. The results confirmed the potential applicability of volatile profiles and flavor properties for classification of PR samples, and this study provided new insights for determining the processing level in food and pharmaceutical industries based on samples with specific flavor characteristics.

Transmission, refraction and dark-field retrieval in hard X-ray grating interferometry.

A three-image algorithm is proposed to retrieve the sample's transmission, refraction and dark-field information in hard X-ray grating interferometry. Analytical formulae of the three-image algorithm are theoretically derived and presented, and evaluated by proof-of-principle synchrotron radiation experiments. The results confirm the feasibility of the proposed algorithm. The novelty of the proposed algorithm is that it allows versatile and tunable multimodal X-ray imaging by substantially relaxing the existing limitations on the lateral grating position. Furthermore, this algorithm can also be adapted for samples with negligible refraction, reducing the number of required sample measurements to two. Furthermore, the noise properties of the retrieved images are investigated in terms of the standard deviations. Theoretical models are presented and verified by synchrotron radiation measurements. It is shown that the noise standard deviations exhibit strong dependence on the lateral grating position, especially in the case of refraction and dark-field images. Further noise reduction and dose reduction can thus be possible by optimizing the lateral grating position for a selected region of interest. Those results can serve as general guidelines to optimize the data acquisition scheme for specific applications and problems.

Quality assessment of Typhae Pollen Carbonisata based on chromaticity analysis combined with UPLC fingerprinting and thrombin activity.

INTRODUCTION: Typhae pollen (TP) has been used as an anticoagulant in traditional Chinese medicine and throughout Asia. Typhae Pollen Carbonisata (TPC), a processed product of TP, has hemostatic properties. TPC is produced by frying TP, and the degree of processing can be judged by the colour change from yellow to brown. OBJECTIVE: To establish a novel method for quality assessment of TPC and discriminate TPC from underdone products and overdone products. METHODOLOGY: The Commission Internationale de l'Eclairage (CIE) L* a* b* colour space values of TP and TPC were measured to establish the colour model of TPC. Ultra-performance liquid chromatography was developed for fingerprinting. Thrombin activity promoting rates, clotting time, and bleeding time illustrated the difference in the hemostatic effect of the processed products. Chemometric approaches were performed to reveal the correlation between components and colour values or thrombin activity. RESULTS: Reference ranges of colour values and mathematical functions of TPC were established. The developed method was found to be fast, economic, sensitive, and stable. Fingerprints and thrombin activity in conjunction with partial least squares (PLS) demonstrated that peaks 2, 4, 7, 30, and 36 (isorhamnetin) were the main contributors for colour values and hemostatic activity of TPC. CONCLUSIONS: TPC and its unqualified products can be effectively distinguished based on chromaticity analysis, which provides a powerful tool for the comprehensive evaluation of the quality of Chinese herbal medicines.

Single-image phase retrieval for hard X-ray grating interferometry.

A single-image method is proposed for quantitative phase retrieval in hard X-ray grating interferometry. This novel method assumes a quasi-homogeneous sample, with a constant ratio between the real and imaginary parts of its complex refractive index. The method is first theoretically derived and presented, and then validated by synchrotron radiation experiments. Compared with the phase-stepping method, the presented approach abandons grating scanning and multiple image acquisition, and is therefore advantageous in terms of its simplified acquisition procedure and reduced data-collection times, which are especially important for applications such as in vivo imaging and phase tomography. Moreover, the sample's phase image, instead of its first derivative, is directly retrieved. In particular, the stripe artifacts encountered in the integrated phase images are significantly suppressed. The improved quality of the retrieved phase images can be beneficial for image interpretation and subsequent processing. Owing to its requirement for a single image and its robustness against noise, the present method is expected to find use in potential investigations in diverse applications.

Optimal design of high-power cascade co-pumping Er/Yb-codoped fiber lasers.

The Yb-ASE problem has been a main obstacle to the power scaling of Er/Yb-codoped fiber lasers (EYDFLs). In this Letter, cascade co-pumping high-power EYDFLs, i.e., EYDFLs with an Yb-band resonant cavity, are proposed and systematically analyzed, for the first time to the best of our knowledge. A high-Q Yb-band cavity is introduced in an EYDFL to lock and recycle the Yb band energy. The oscillation wavelength of the Yb cavity, the reflectivity of the output fiber grating, and the length of the fiber are optimized numerically. Thermal effects are also considered in the study. The simulation results show that compared to ordinary EYDFLs, the introduction of an appropriate Yb cavity can not only effectively suppress the Yb-ASE, increase the output power, and improve the pump conversion efficiency, but can also greatly shorten the optimal gain fiber length. Cascade co-pumping is a promising way to improve the performance of high-power EYDFLs.

Apigenin Retards Atherogenesis by Promoting ABCA1-Mediated Cholesterol Efflux and Suppressing Inflammation.

BACKGROUND/AIMS: The development of atherosclerosis is accompanied by escalating inflammation and lipid accumulation within blood vessel walls. ABCA1 plays a crucial role in mediating cholesterol efflux from macrophages, which protects against atherogenesis. This research was designed to explore the effects and underlying mechanisms of apigenin (4', 5, 7-trihydroxyflavone) on ABCA1-mediated cellular cholesterol efflux and LPS-stimulated inflammation in RAW264.7 macrophages and apoE-/- mice. METHODS: Expression of genes or proteins was examined by RT-PCR or western blot analysis. Liquid scintillation counting was used to detect percent cholesterol efflux. Cellular cholesterol content was measured using HPLC assay. The secretion levels of pro-inflammatory cytokines were quantified by ELISA assay. Atherosclerotic lesion sizes were determined with Oil Red O staining. The contents of macrophages and smooth muscle cells in atherosclerotic lesion were evaluated using immunohistochemistry. Plasma TC, TG, HDL-C and LDL-C levels in apoE-/- mice were evaluated using commercial test kits. RESULTS: Apigenin potently increased ABCA1 expression through miR-33 repression in a dose- and time-dependent manner. Treatment with apigenin significantly increased ABCA1-mediated cholesterol efflux, and reduced TC, FC and CE levels in macrophage-derived foam cells. In LPS-treated macrophages, the expression levels of TLR-4, MyD88 and p-IκB-α as well as nuclear NF-κB p65 were decreased by the addition of apigenin. Moreover, apigenin markedly decreased secretion levels of several pro-inflammatory cytokines. Lastly, in LPS-challenged apoE-/- mice, apigenin administration augmented ABCA1 expression, decreased the contents of macrophages and smooth muscle cells in atherosclerotic lesion, reduced miR-33, TLR-4, and NF-κB p65 levels, improved plasma lipid profile and relieved inflammation, which results in less atherosclerotic lesion size. CONCLUSIONS: Taken together, these results suggest that apigenin may attenuate atherogenesis through up-regulating ABCA1-mediated cholesterol efflux and inhibiting inflammation.

Method for estimating the Stark splitting of rare-earth ions from the measured cross-section spectra.

A method to estimate the Stark levels of the rare-earth ions doped in a laser medium from the measured emission and absorption cross-sections is proposed. The method is based on the McCumber theory, which can calculate the emission/absorption cross-sections from the given Stark levels. By fitting the calculated emission/absorption spectra to the measured ones through a numerical optimization process, the Stark levels of the RE ions can be determined. As examples, the Stark levels of the laser-emission-related manifolds of Er3+ and Yb3+ ions in a gain fiber and two doped glasses have been determined by the proposed method. The data were then used to analyze the temperature-dependent population of the Stark levels. This method avoids the difficulties in direct measurement of the Stark levels in a cryogenic temperature environment. It is important to the evaluation of the thermal load, distribution, and design of the thermal management system of high-power fiber lasers and amplifiers.

Self-Reference Refractive Index Sensor Based on Independently Controlled Double Resonances in Side-Coupled U-Shaped Resonators.

A plasmonic, refractive, index nanosensor is investigated theoretically and numerically in two U-shaped cavities side-coupled to a metal⁻dielectric⁻metal (MDM) waveguide. A transparency window between two transmission dips is observed. The physical origin of the transmission phenomenon is revealed by mapping the magnetic field distribution. Independent double resonances are realized through the proposed design. Double resonances showed diverse responses to the variations of the structural dimensions. In particular, they presented different dependences on a refraction index of the medium in an individual resonator. One resonance exhibited a remarkable shift with the increase of the refraction index; however, the other resonance remained unchanged. On the basis of this unique characteristic of differing sensitivities, self-reference sensing is discussed. The nanosensor yielded a high sensitivity of 917 nm/RIU and a figure of merit of 180 RIU−1. This work is helpful in terms of the design of on-chip optical sensors with high sensitivity and improved detection accuracy in complicated environments.

Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner.

BACKGROUND/AIMS: Previous studies have demonstrated that leonurine, a unique alkaloid compound of Herba leonuri, can exert anti-oxidative and anti-inflammatory effects on the development of atherosclerosis (AS). This study was designed to investigate the effects of leonurine on cholesterol efflux from THP-1 macrophage-derived foam cells and development of atherosclerotic lesions in apoE-/- mice, and further determine the potential mechanisms. METHODS: Human THP-1 cells were fully differentiated into foam cells by the pre-treatment with phorbol-12-myristate-13-acetate (PMA) and oxidized density lipoproteins (ox-LDL). After cells were incubated with various concentrations of leonurine, Oil Red O staining and high-performance liquid chromatography (HPLC) assays were utilized to detect cellular lipid accumulation and cholesterol content, respectively. Cellular cholesterol efflux was determined by liquid scintillation counting. The mRNA and protein levels of ATP-binding cassette transporter A1/G1 (ABCA1/G1), peroxisome proliferator-activated receptor γ (PPARγ) and liver X receptor α (LXRα) in foam cells were assessed using real-time quantitative PCR (RT-qPCR) and western blot analyses, respectively. Plasma triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) levels in apoE-/- mice were evaluated using enzymatic methods. The atherosclerotic lesion sizes and collagen contents in aortic roots were determined by Oil Red O and Masson's trichrome staining, respectively. RESULTS: Oil Red O staining and liquid scintillation counting assays showed that leonurine significantly inhibited lipid accumulation and promoted 3H-cholesterol efflux in human THP-1 macrophage-derived foam cells in a concentration-dependent manner. Besides, both the mRNA and protein levels of ABCA1/G1, PPARγ and LXRα were enhanced by leonurine, which were attenuated by LXRα siRNA or PPARγ siRNA transfection. Finally, leonurine improved plasma lipid profile, decreased atherosclerotic lesion sizes, increased collagen contents and amplified PPARγ, LXRα and ABCA1/G1 expressions in aortic roots of apoE-/- mice. CONCLUSIONS: Leonurine can promote cholesterol efflux and alleviate cellular lipid accumulation by magnifying the expression of ABCA1/G1 in a PPARγ/LXRα signaling pathway-dependent manner in human THP-1 macrophage-derived foam cells and abate atherogenesis in apoE-/- mice, which may offer a promising therapeutic intervention of leonurine in protecting against AS.

Tunable compact nanosensor based on Fano resonance in a plasmonic waveguide system.

An ultracompact plasmonic refractive index sensor based on Fano resonance is proposed. The sensor comprises a metal-insulator-metal waveguide with a stub and a side-coupled split-ring resonator. The effect of structural parameters on Fano resonance and the refractive index sensitivity of the system are analyzed in detail by investigating the transmission spectrum. Simulation results show that Fano resonance has different dependences on the parameters of the sensor structure. The reason is further discussed based on the field pattern. The peak wavelength and lineshape can be easily tuned by changing the key parameters. Furthermore, dual Fano resonance effects with different frequency intervals are obtained, which are mainly induced by the symmetry breaking of the structure. The proposed sensor yields sensitivity higher than 1.4×103 nm/RIU and a figure of merit of 1.2×105. The sensitivity and figure of merit can be further improved by optimizing the geometry parameters.

Clinical research of the five needles combined with rehabilitation training treatment dysphagia after stroke.

To compare therapeutic effects of Five Needles of the Nape and routine acupuncture on treatment of pseudo bulbar paralysis dysphagia after Brain stroke. 60 patients were randomly divided into five key groups and routine acupuncture, and 30 cases in each group. The group of Five Needles of the Nape set points to take dumb door, Tianzhu, cure choke point with acupuncture treatment which cooperate with swallowing training . The group of routine acupuncture set points to take Lian Quan, Tong Li, Zhao Hai points with acupuncture treatment. Both groups were acupunctured once a day, 6 times a week and 2 weeks is a period of treatment, evaluating curative effect after two courses of treatment. The total effective rate of Five Needles of the Nape group was 93.3%, when the total effective rate of routine acupuncture group was 80.0%.as a consequence Five Needles of the Nape group is superior to routine acupuncture group (P<0.05). Five Needles of the Nape have better clinical efficacy than routine acupuncture on treatment of pseudo bulbar paralysis dysphagia after Brain stroke.

Influences of Bushen Xingnao Decoction on expression of vascular endothelial growth factor, IL-1ß and tumor necrosis factor-α in vascular dementia rats.

To observe influences of Bushen Xingnao Decoction (BSXND) on expression of vascular endothelial growth factor (VEGF), IL-1ßß and tumor necrosis factor-α (TNF-α) in brain tissues and serum level of vascular dementia rats and to investigate neuroprotective mechanism of BSXND for vascular dementia. Wistar rats were randomly divided into normal group (N group), sham operation group (S group), dementia model group (M group) and Bushen Xingnao decoction treatment group (MT group). After the model was successfully established, 2, 4, 6 weeks were regarded as observation point. Expressions of VEGF, IL-1ß and TNF-α in serum and brain of rat brain were measured by enzyme linked immunosorbent assay. The expressions of IL-1ß and TNF-α in MT group were lower than those in M group (P&< 0.05), the expression of VEGF in MT group was higher than that in M group (P&< 0.05); the expressions of VEGF, IL-1ß and TNF-α in MT and M groups were higher than those in N and S groups (P&<0.01). BSXND can reduce the levels of IL-1ß and TNF-α in brain tissues and serum of vascular dementia rats and increase the expression of VEGF. BSXND can play cerebral protective role by suppressing the neuroinflammation response of vascular dementia rats and enhancing vascular repair.

A multiobjective interval programming model for wind-hydrothermal power system dispatching using 2-step optimization algorithm.

Wind-hydrothermal power system dispatching has received intensive attention in recent years because it can help develop various reasonable plans to schedule the power generation efficiency. But future data such as wind power output and power load would not be accurately predicted and the nonlinear nature involved in the complex multiobjective scheduling model; therefore, to achieve accurate solution to such complex problem is a very difficult task. This paper presents an interval programming model with 2-step optimization algorithm to solve multiobjective dispatching. Initially, we represented the future data into interval numbers and simplified the object function to a linear programming problem to search the feasible and preliminary solutions to construct the Pareto set. Then the simulated annealing method was used to search the optimal solution of initial model. Thorough experimental results suggest that the proposed method performed reasonably well in terms of both operating efficiency and precision.

Enhancing Earth data analysis in 5G satellite networks: A novel lightweight approach integrating improved deep learning.

Efficiently handling huge data amounts and enabling processing-intensive applications to run in faraway areas simultaneously is the ultimate objective of 5G networks. Currently, in order to distribute computing tasks, ongoing studies are exploring the incorporation of fog-cloud servers onto satellites, presenting a promising solution to enhance connectivity in remote areas. Nevertheless, analyzing the copious amounts of data produced by scattered sensors remains a challenging endeavor. The conventional strategy of transmitting this data to a central server for analysis can be costly. In contrast to centralized learning methods, distributed machine learning (ML) provides an alternative approach, albeit with notable drawbacks. This paper addresses the comparative learning expenses of centralized and distributed learning systems to tackle these challenges directly. It proposes the creation of an integrated system that harmoniously merges cloud servers with satellite network structures, leveraging the strengths of each system. This integration could represent a major breakthrough in satellite-based networking technology by streamlining data processing from remote nodes and cutting down on expenses. The core of this approach lies in the adaptive tailoring of learning techniques for individual entities based on their specific contextual nuances. The experimental findings underscore the prowess of the innovative lightweight strategy, LMAED2L (Enhanced Deep Learning for Earth Data Analysis), across a spectrum of machine learning assignments, showcasing remarkable and consistent performance under diverse operational conditions. Through a strategic fusion of centralized and distributed learning frameworks, the LMAED2L method emerges as a dynamic and effective remedy for the intricate data analysis challenges encountered within satellite networks interfaced with cloud servers. The empirical findings reveal a significant performance boost of our novel approach over traditional methods, with an average increase in reward (4.1 %), task completion rate (3.9 %), and delivered packets (3.4 %). This report suggests that these advancements will catalyze the integration of cutting-edge machine learning algorithms within future networks, elevating responsiveness, efficiency, and resource utilization to new heights.

METTL3-mediated m6 A methylation of TRAF5 inhibits lung adenocarcinoma cell metastasis via activation of the PI3K/AKT/NF-κB signaling pathway.

Tumor necrosis factor receptor-associated factor 5 (TRAF5) has been implicated in the pathogenesis of human malignancies. This work aimed to clarify the role of TRAF5 in lung adenocarcinoma (LUAD) progression. Herein, we uncovered that TRAF5 level was reduced in LUAD tissues. Low TRAF5 expression correlated with dismal prognosis in LUAD patients. Moreover, upregulated TRAF5 impeded cell viability, migration, and invasion, induced apoptosis in vitro, as well as impaired tumorigenicity in vivo. However, depletion of TRAF5 revealed opposing results. Moreover, TRAF5 was identified as the downstream target of methyltransferase-like 3 (METTL3)-elicited N6 -methyladenosine (m6 A) modification. METTL3 stabilized TRAF5 mRNA and positively modulated TRAF5 level. Further, TRAF5 depletion relieved the repressive phenotype caused by METTL3 addition. In addition, it was manifested that the METTL3/TRAF5 axis served as an inhibitor in LUAD through the PI3K/AKT/Nuclear Factor-Kappa B (NF-κB) signaling. Collectively, we propose that METTL3-mediated TRAF5 m6 A modification exerted as a vital tumor inhibitory function in LUAD development. The METTL3/TRAF5 axis may be a critical effector of LUAD progression.

Association of dietary niacin intake with the prevalence and incidence of chronic obstructive pulmonary disease.

Evidence regarding the association between dietary niacin intake and chronic obstructive pulmonary disease (COPD) is limited. Our study investigates the relationship between dietary niacin intake and the prevalance and incidence of COPD in the adult population of the United States, using data from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2018. Data on niacin intake were extracted through dietary intake interviews. COPD diagnoses were based on lung function, medical history, and medication usage. We analyzed the association between niacin consumption and COPD using multiple logistic regression and restricted cubic spline models. The study included 7055 adult participants, divided into COPD (n = 243; 3.44%) and non-COPD (n = 6812; 96.56%) groups. Those with COPD had lower average niacin intake (21.39 ± 0.62 mg/day) compared to the non-COPD group (25.29 ± 0.23 mg/day, p < 0.001). In the adjusted multivariable model, the odds ratios (OR) and 95% confidence intervals (CI) for COPD in the highest versus lowest quartile of dietary niacin intake were 0.55 (0.33 to 0.89, P for trend = 0.009). Subgroup analysis, after adjustment for various variables, revealed no significant interaction effects. Dietary niacin intake was inversely associated with COPD prevalence in US adults. Participants with the highest dietary niacin intake demonstrated the lowest odds of COPD. The potential of dietary niacin supplementation as a strategy to mitigate COPD warrants further investigation.