Is oral microbiota associated with overweight and obesity in children and adolescents? A systematic review.

This article aims to verify the relationship between the composition and diversity of oral microbiota with overweight and obese children and adolescents. This systematic review was registered in PROSPERO, followed PRISMA 2020, and included an electronic search until March 2022, in PubMed/MEDLINE, Web of Science, Scopus, and The Cochrane Library databases. Studies were eligible if they compared the oral microbiota according to nutrition status among children and adolescents. Independent peers using JBI Critical Appraisal Checklists assessed the quality of studies. Eleven studies were eligible to be included in this review, with a total of 1,695 children and adolescents, 224 were obese, 190 were overweight, 1,154 were eutrophics and 127 were underweight. The most frequent phyla in overweight and obese children and adolescents, in comparison to their counterparts were Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria and Fusobacteria. It was identified that nine of the eleven articles selected showed an association between oral microbiota and overweight and obesity in children and adolescents. We observed that there is an important association between oral bacterial composition diversity and overweight and obesity. This finding indicates the relevance of the evaluation and surveillance in oral health to control cases of overweight and obesity in children and adolescents.

Higher atherogenic risk in schoolchildren is associated with MTMR9 rs2293855 gene polymorphism and genetic score.

Childhood dyslipidaemia is associated with the occurrence of cardiovascular diseases in adulthood, so evaluating whether an individual has a genetic predisposition to this pathology is of great importance for early action of prevention and treatment. This study aimed to evaluate the association between the FTO (rs9939609), MC4R (rs17782313) and MTMR9 (rs2293855) polymorphisms, the obesity-related genetic risk score and atherogenic risk in Brazilian children. This is a cross-sectional study conducted in 544 children aged 4-9 years in the city of Viçosa, Minas Gerais state, Brazil. The single nucleotide polymorphisms rs9939609, rs17782313 and rs2293855, were identified by the system TaqMan SNP genotyping and the obesity-related genetic risk score was determined. The lipid profile (serum total cholesterol [TC], high density lipoprotein [HDL] cholesterol, low density lipoprotein [LDL] cholesterol, triglycerides) was analysed and the atherogenic indices (Castelli I and II indices), atherogenic coefficient (AC), lipoprotein combined index (LCI) and plasma atherogenic index (PAI) were calculated. A semi-structured questionnaire was applied, obtaining data on the sociodemographic, economic and lifestyle characteristics of the children. Weight and height measurements were performed in all children, and body composition was evaluated by Dual-Energy X-ray Absorptiometry (DXA). 55.5% of the sample had dyslipidaemia, while 28.5% of the sample had at least one polymorphism and 2.2% had three polymorphisms. Children with the AG/AA genotypes in the rs2293855 polymorphism had lower HDL cholesterol levels and higher TC/HDL cholesterol, LDL/HDL cholesterol ratios and AC. Those with one or more polymorphisms (rs9939609, rs17782313 and rs2293855) in the genetic risk score had lower HDL cholesterol levels and higher TC/HDL cholesterol ratios, AC, LCI and PAI. In conclusion, the risk allele of the rs2293855 polymorphism and a higher obesity-related genetic risk score were positively associated with higher atherogenic risk in Brazilian children.

Accurate determination of energy needs in children and adolescents with cancer.

Studies on children with cancer have suggested that energy expenditure may indeed be greater than predicted for healthy children. Nutritional assessment is important for intervention and for the prevention of complications associated with malnutrition. The present study aimed to describe the nutritional status, energy expenditure, and substrate utilization of children and adolescents with cancer compared to healthy children matched for age, sex, and body mass index. Subjects were evaluated by anthropometry, food intake pattern, and body composition analysis. Energy expenditure and substrate oxidation were measured by indirect calorimetry. Indirect calorimetry data, energy, and macronutrient intake, anthropometry, and body composition parameters showed no significant differences between groups. There was no evidence of increased energy expenditure or of a change in substrate utilization in children with cancer compared to the healthy group. The data regarding usual food consumption showed no significant differences between groups.

Polymorphisms on rs9939609 FTO and rs17782313 MC4R genes in children and adolescent obesity: A systematic review.

The aim of this review was to assess whether the presence of rs9939609 and rs17782313 polymorphisms increase the risk for obesity among children and adolescents. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist and it was registered in PROSPERO. The search was performed in the PubMed/Medline, The Cochrane Library, and Web of Science databases. The risk of bias of the studies was accessed using the Newcastle-Ottawa scale and JBI Critical Appraisal Checklist for Analytical. The search of the databases retrieved 859 references. Twelve studies were eligible to be included in this systematic review. Five studies founded a positive association between overweight and obesity in children and adolescents with the presence of the rs17783213 and four studies with rs9939609. Three studies did not find an association between overweight and obesity in children and adolescents with the presence of rs17782313 or rs9939609. One found a protective effect for obesity in individuals with risk A allele referring to rs9939609, one found a synergistic effect in relation to the presence of polymorphisms rs17782313 and rs9939609 for obese phenotype, and one observed that the presence together of the rs9939609, rs17782313, and rs12970134 MC4R were significant for the presence of obesity in children and adolescents. The results suggest that depending on the population evaluated and ethnicity, the polymorphisms rs17782313 and rs9939609 could be associated with overweight and obesity in children and adolescents.

The polymorphism rs17782313 near MC4R gene is related with anthropometric changes in women submitted to bariatric surgery over 60 months.

OBJECTIVE: Evaluate whether the polymorphism rs17782313 near MC4R gene influences long-term outcomes after bariatric surgery. METHODS: The rs16782313 polymorphism was genotyped in 217 individuals undergoing bariatric surgery and analyzed in detail in 141 women. Data for comorbidities, BMI, excess weight loss (EWL), and body composition were obtained before and during 60 months after surgery. RESULTS: The risk allele was found in 65 (47%) of the 141 women. Pre-surgical body weight and BMI were higher in carriers of the rs17782313 polymorphism (CC + CT group) than in non-carriers (TT group) (p = 0.039 and 0.047, respectively). The number of women who acquired surgical success (EWL > 50%), was lower in CC + CT group compared to TT group (p = 0.015). The minimum BMI seen during the 60 months of follow-up was higher in CC + CT group compared to TT group (p = 0.028). The number of women who presented BMI < 30 kg/m2 (no longer classified as obesity) after 24 months of surgery was inferior in CC + CT group (6 out 35 patients - 17%) than in TT group (19 out 49 patients - 37%, p = 0.043). Moreover, the number of patients maintaining BMI > 35 kg/m2 were higher carriers (18 out 35 patients - 51%) compare to non-carriers (16 out 49 patients - 32%, p = 0.045). CONCLUSION: Women with extreme obesity carrying rs17782313 MC4R polymorphism present a higher pre-surgical BMI, are more unlikely to reach non-obesity BMI (<30 kg/m2) and tend to maintain a BMI > 35 kg/m2 that characterize treatment failure.

Violência no contexto escolar e ideação suicida na adolescência / Violencia en el contexto escolar e ideación suicida en la adolescencia / Violence in the school context and suicidal ideation in adolescence

Objetivo: analisar a violência escolar sofrida e praticada e a sua associação com a ideação suicida, entre adolescentes com 12 a 18 anos. Método: pesquisa realizada com 643 adolescentes, matriculados em escolas estaduais da cidade do Recife, Pernambuco, Brasil. Foram aplicados dois questionários: "Global School-based Student Health Survey" e "Violência na Escola". Para análise estatística utilizou-se o teste Qui-quadrado, grau de associação foi analisado por meio da razão de prevalências. Resultados: as prevalências de violência escolar e de ideação suicida foram de 62,2% e 17,4%, respectivamente. Cerca de 28% dos adolescentes relataram já terem se sentido muito triste, 14% deles declararam sentir solidão frequentemente. Houve associação significativa da ideação suicida com a violência sofrida na faixa etária de 15-18 anos. Conclusão: os resultados apontam para a necessidade de ações de saúde, que visem fortalecer os fatores de proteção e prevenção das situações de risco para a violência e ideação suicida.

Objective: to analyze the school violence suffered and practiced and its association with suicidal ideation among adolescents aged 12 to 18 years. Method: study conducted with 643 adolescents registered in state schools in the city of Recife, Pernambuco, Brazil. Two questionnaires were applied: "Global School-based Student Health Survey" and "Violence at School". For statistical analysis, the Chi-square test was used, degree of association was analyzed using the prevalence ratio. Results: the prevalence of school violence and suicidal ideation was 62.2% and 17.4%, respectively. About 28% of the adolescents reported having felt very sad, 14% of them reported feeling loneliness frequently. There was a significant association between suicidal ideation and violence in the age group of 15-18 years. Conclusion: the results point to the need for health actions aimed at strengthening the protective and prevention factors of risk situations for violence and suicidal ideation.

Objetivo: analizar la violencia escolar sufrida y practicada y su asociación con la ideación suicida entre adolescentes de 12 a 18 años. Método: estudio realizado con 643 adolescentes matriculados en escuelas estatales en la ciudad de Recife, Pernambuco, Brasil. Se aplicaron dos cuestionarios: "Global School-based Student Health Survey" y "Violencia en la Escuela". Para el análisis estadístico, se utilizó la prueba Chi-cuadrada, se analizó el grado de asociación utilizando la relación de prevalencia. Resultados: la prevalencia de la violencia escolar y la ideación suicida fue del 62,2% y del 17,4%, respectivamente. Alrededor del 28% de los adolescentes informaron que se habían sentido muy triste, el 14% de ellos reportaron sentir la soledad con frecuencia. Hubo una asociación significativa entre la ideación suicida y la violencia en el grupo de edad de 15-18 años. Conclusión: los resultados apuntan a la necesidad de acciones sanitarias encaminadas a fortalecer los factores de protección y prevención de las situaciones de riesgo para la violencia y la ideación suicida.

Resting energy expenditure adaptation after short-term caloric restriction in morbidly obese women / Adaptação do gasto energético de repouso após restrição calórica de curto prazo em mulheres com obesidade mórbida

Objective:The objective of this study was to describe changes in the resting energy expenditure, substrate oxidation rate, and body composition in morbidly obese women subjected to short-term caloric restriction. Methods:This was a prospective study that included ten obese women with body mass index greater than 40 kg/m2 and aged between 20-50 years. The participants were hospitalized for eight days and received a controlled conventional low-calorie diet, 1200 kcal/day, for seven days. Body weight, body mass index, abdominal circumference, body composition, resting energy expenditure, and substrate oxidation rate were evaluated at the beginning and at the end of the study. Results:A significant reduction in body weight (p=0.005), body mass index (p=0.005), abdominal circumference (p=0.005), fat mass (p=0.005) and fat-free mass (p=0.008) was observed at the end of the study. There was an average reduction in resting energy expenditure of approximately 124 kcal/day (5%). Substrate oxidation rate did not show statistically significant changes. There was a positive correlation only between body weight reduction and fat-free mass reduction (r=0.753; p=0.012). Conclusion:There was an adaptive response of the resting energy expenditure with short-term energy restriction in morbidly obese women with a 5% reduction in resting energy expenditure and a positive correlation between weight loss and the fat-free mass, which indicates the influence of fat-free mass on the decrease in resting energy expenditure. Therefore, short-term caloric restriction in morbidly obese women led to a decrease in resting energy expenditure and fat-free mass, which suggests a rapid adaptation of energy expenditure.

Objetivo:Descrever as mudanças no gasto energético de repouso, na taxa de oxidação de substrato e na composição corporal em mulheres obesas mórbidas submetidas à restrição calórica de curto prazo. Métodos:Este foi um estudo prospectivo com dez mulheres obesas com índice de massa corporal maior que 40 kg/m2 e idade entre 20-50 anos. As participantes foram hospitalizadas por sete dias consecutivos e receberam uma dieta hipocalórica convencional controlada de 1200 kcal/dia. Peso corporal, índice de massa corporal, circunferência abdominal, composição corporal, gasto energético de repouso e taxa de oxidação de substratos foram avaliados no início e no final do estudo.Resultados:Reduções significativas no peso corporal (p=0,005), índice de massa corporal (p=0,005), circunferência abdominal (p=0,005), massa gorda (p=0,005) e massa livre de gordura (p=0,008) foram observadas no final do estudo. O gasto energético de repouso mostrou redução média de aproximadamente 124 kcal/dia (5%). A taxa de oxidação de substratos não apresentou mudanças estatisticamente significativas. Houve correlação importante apenas entre a redução do peso corporal e a redução da massa livre de gordura (r=0,753, p=0,012). Conclusão:Houve uma resposta adaptativa do gasto energético de repouso com restrição energética em curto prazo em mulheres obesas mórbidas, apresentando redução média de 5% do gasto energético de repouso e correlação entre a perda de peso e a massa livre de gordura, o que indica a influência da mesma na diminuição do gasto energético de repouso. Portanto, a restrição calórica de curto prazo em mulheres obesas mórbidas leva à diminuição no gasto energético de repouso e na massa livre de gordura, sugerindo uma rápida adaptação do gasto energético.

Dietary Intake, Anthropometric and Body Composition Assessment of Adolescents Enrolled in a Basic Health Unit in Ribeirão Preto, São Paulo, Brazil / Ingestão dietética, avaliação antropométrica e composição corporal de adolescentes atendidos em um Centro de Atenção Primária à Saúde em Ribeirão Preto, São Paulo, Brasil

Objectives: This study aimed to describe and compare the nutritional profile of three groups of adolescents of the same age and gender, diagnosed as overweight, obese and eutrophic as determined by the Body Mass Index (BMI). Materials and Methods: This is a cross-sectional, observational, comparative, and descriptive study in which adolescents were evaluated using anthropometric measurements suchas skinfolds, waist circumference, BMI and body composition assessed by bioelectric impedance. Asemi-quantitative questionnaire about eating frequency was applied to evaluate food intake. The sample was determined by convenience. A total of 517 adolescents were attended at the CMSCVL between October 2005 and December 2006. Of these, 141 (27.3%) agreed to participate and satisfied the inclusion criteria...

Objetivos: Este estudo teve como objetivo descrever e comparar o perfil nutricional de três grupos de adolescentes da mesma idade e sexo, com diagnóstico de sobrepeso, obesidade e eutrofia, determinado pelo Índice de Massa Corporal (IMC). Materiais e Métodos: Estudo transversal, observacional, comparativo, descritivo, no qual os adolescentes foram avaliados utilizando medidas antropométricas, tais como dobras cutâneas, circunferência da cintura, IMC e composição corporal avaliada pela impedância bioelétrica. Um questionário semi-quantitativo sobre a freqüência alimentar foi aplicado para avaliar a ingestão de alimentos. A amostra foi determinada por conveniência. Foram atendidos no CMSCVL, no período entre outubro de 2005 e dezembro de 2006, 517 adolescentes. Desse total, 141 (27,3%) concordaram em participar e estavam dentro dos critérios de inclusão...