Detalhe da pesquisa
1.
Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis.
Cell
; 167(7): 1734-1749.e22, 2016 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27984724
2.
Allele-Specific Silencing Ameliorates Restrictive Cardiomyopathy Attributable to a Human Myosin Regulatory Light Chain Mutation.
Circulation
; 140(9): 765-778, 2019 08 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31315475
3.
Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity.
Toxicol Appl Pharmacol
; 406: 115213, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32877659
4.
Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes.
Circ Res
; 120(10): 1572-1583, 2017 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28400398
5.
Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness.
Proc Natl Acad Sci U S A
; 112(41): 12705-10, 2015 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26417073
6.
Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation.
FASEB J
; 30(4): 1464-79, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26675706
7.
For whom the cells pull: Hydrogel and micropost devices for measuring traction forces.
Methods
; 94: 51-64, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26265073
8.
Give heart cells a beat: An interactive museum exhibit that synchronizes stem cell-derived cardiomyocytes to visitors' heartbeat.
Stem Cell Reports
; 19(3): 426-433, 2024 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38335963
9.
Reproducibility of drug-induced effects on the contractility of an engineered heart tissue derived from human pluripotent stem cells.
Front Pharmacol
; 14: 1212092, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37469866
10.
Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment.
Toxicol Sci
; 190(2): 117-126, 2022 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36099065
11.
IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making.
Toxics
; 10(5)2022 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35622645
12.
Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate).
ALTEX
; 39(2): 297314, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35064273
13.
Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes.
J Pharmacol Toxicol Methods
; 110: 107083, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34098110
14.
Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism, and accumulation.
Clin Transl Sci
; 14(3): 1049-1061, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33382907
15.
CRISPR/Cas9-based targeting of fluorescent reporters to human iPSCs to isolate atrial and ventricular-specific cardiomyocytes.
Sci Rep
; 11(1): 3026, 2021 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33542270
16.
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes.
Stem Cell Reports
; 16(9): 2169-2181, 2021 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34019816
17.
Nuclear shape, mechanics, and mechanotransduction.
Circ Res
; 102(11): 1307-18, 2008 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-18535268
18.
Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method.
J Pharmacol Toxicol Methods
; 105: 106895, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32629158
19.
Liver Microphysiological Systems for Predicting and Evaluating Drug Effects.
Clin Pharmacol Ther
; 106(1): 139-147, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30993668
20.
Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms.
Front Pharmacol
; 10: 884, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31447679