Detalhe da pesquisa
1.
Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
Blood
; 142(1): 44-61, 2023 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37023372
2.
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models.
Prostate
; 84(10): 909-921, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38619005
3.
Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss.
BMC Med Genet
; 21(1): 35, 2020 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32066420
4.
LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML.
Blood
; 131(15): 1730-1742, 2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29453291
5.
The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy.
Haematologica
; 106(11): 3004-3007, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233450
6.
A public resource facilitating clinical use of genomes.
Proc Natl Acad Sci U S A
; 109(30): 11920-7, 2012 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22797899
7.
Cardiac R2* values are independent of the image analysis approach employed.
Magn Reson Med
; 72(2): 485-91, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24123261
8.
A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload.
Blood
; 119(14): 3263-8, 2012 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22251482
9.
R2 and R2* are equally effective in evaluating chronic response to iron chelation.
Am J Hematol
; 89(5): 505-8, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24452753
10.
A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome.
Am J Med Genet A
; 161A(8): 2040-6, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23824657
11.
Bomedemstat as an investigative treatment for myeloproliferative neoplasms.
Expert Opin Investig Drugs
; 32(10): 879-886, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37804041
12.
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes.
Wellcome Open Res
; 8: 146, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37520936
13.
Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41.
Blood Adv
; 7(20): 6092-6107, 2023 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37406166
14.
Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing.
Clin Cancer Res
; 28(20): 4551-4564, 2022 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35920742
15.
A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload.
Haematologica
; 96(4): 521-5, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21173101
16.
Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse.
Am J Physiol Endocrinol Metab
; 298(6): E1236-43, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20354157
17.
Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition.
Cancer Discov
; 10(10): 1500-1513, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32606137
18.
RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML.
Blood Adv
; 4(6): 1131-1144, 2020 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32208489
19.
Response to "De novo mutation of the TGFB3 latency-associated peptide domain in a patient with overgrowth and Loeys-Dietz syndrome features".
Am J Med Genet A
; 164A(8): 2144-5, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24817670
20.
The use of appropriate calibration curves corrects for systematic differences in liver R2* values measured using different software packages.
Br J Haematol
; 161(6): 888-91, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23496418