Detalhe da pesquisa
1.
1,25-Dihydroxyvitamin D3 suppresses CD4+ T-cell effector functionality by inhibition of glycolysis.
Immunology
; 166(3): 299-309, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35322416
2.
Positron emission tomography and magnetic resonance imaging in experimental human malaria to identify organ-specific changes in morphology and glucose metabolism: A prospective cohort study.
PLoS Med
; 18(5): e1003567, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34038421
3.
Optimised collection of non-uniformly sampled 2D-HSQC NMR spectra for use in metabolic flux analysis.
Magn Reson Chem
; 59(3): 287-299, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32830359
4.
Quantitative Isotopomer Rates in Real-Time Metabolism of Cells Determined by NMR Methods.
Chembiochem
; 20(17): 2207-2211, 2019 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30990951
5.
TNF-α signals through ITK-Akt-mTOR to drive CD4+ T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis.
Sci Signal
; 17(833): eadg5678, 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38652761
6.
Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia.
Sci Rep
; 14(1): 1729, 2024 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38242919
7.
LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic ß cells.
Cell Rep
; 43(4): 114047, 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38607916
8.
VHL-deficiency leads to reductive stress in renal cells.
Free Radic Biol Med
; 208: 1-12, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506952
9.
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.
Cell Rep
; 42(5): 112372, 2023 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37086404
10.
Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation.
Cell Rep
; 40(7): 111193, 2022 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35977513
11.
Positron emission tomography and magnetic resonance imaging of the brain in experimental human malaria, a prospective cohort study.
Sci Rep
; 12(1): 5696, 2022 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35383257
12.
Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell.
Sci Rep
; 12(1): 19657, 2022 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36385275
13.
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Cell Rep
; 38(5): 110320, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35108535
14.
Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2.
Sci Rep
; 11(1): 9092, 2021 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33907288
15.
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
Cancer Res
; 81(13): 3480-3494, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34127497
16.
A framework for tracer-based metabolism in mammalian cells by NMR.
Sci Rep
; 9(1): 2520, 2019 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30792403
17.
Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy.
Blood Adv
; 7(10): 2228-2236, 2023 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36399517
18.
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722).
J Med Chem
; 61(18): 8226-8240, 2018 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30199249
19.
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
J Med Chem
; 59(8): 3671-88, 2016 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27055065