[Clinical and evolutive study of plasma cell leukemia. Apropos of 9 cases]. / Estudio clínico y evolutivo de la leucemia de células plasmáticas. A propósito de nueve casos.

Nine patients were diagnosed with plasma cell leukemia (PCL) from 1982-1995 at our hospital. Seven patients had primary PCL and the other two patients a secondary from. In this study the clinical and analytical features are reported, as well as the therapy and response obtained in these patients. Also, the karyotype findings in bone marrow of four of these patients are reported. At diagnosis, the most common symptom was bone pain which was associated with osteolytic lesions or diffuse bone demineralization. Analytical features were similar to those reported in other series of patients with PCL. Different therapeutical regimens were used, and VAD was the most commonly employed. Two patients underwent consolidation therapy with autologous transplantation of hemopoietic stem cells. The mean survival time was 5.5 months. Although PCL prognosis associated with chemotherapy is still poor, myeloablative therapy with hemopoietic support can increase the survival length in these patients.

[Simultaneous presentation of multiple myeloma and sarcoidosis]. / Mieloma múltiple y sarcoidosis de presentación simultánea.

The association between sarcoidosis and neoplasms has been described by different authors. Hodgkin's disease and non Hodgkin lymphoma are the neoplasms associated frequently with sarcoid reaction. However, the simultaneous appearance of multiple myeloma disease and sarcoidosis is very infrequent because only eleven cases have been described. The case of a 49 year old patient with simultaneous appearance of smoldering myeloma and sarcoidosis is presented. The smoldering myeloma had an aggressive evolution to multiple myeloma. The role that sarcoidosis may play in the genesis of multiple myeloma is discussed.