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Bioorg Med Chem Lett
; 14(22): 5569-72, 2004 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15482926
RESUMO
The preparation and evaluation of novel aryl urea analogs as broad-spectrum antibacterial agents is described. Numerous compounds showed low micromolar minimum inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria. Selected analogs also exhibited in vivo efficacy in a lethal murine model of bacterial septicemia.