An in-depth examination of requirements for disclosure risk assessment.

The use of formal privacy to protect the confidentiality of responses in the 2020 Decennial Census of Population and Housing has triggered renewed interest and debate over how to measure the disclosure risks and societal benefits of the published data products. We argue that any proposal for quantifying disclosure risk should be based on prespecified, objective criteria. We illustrate this approach to evaluate the absolute disclosure risk framework, the counterfactual framework underlying differential privacy, and prior-to-posterior comparisons. We conclude that satisfying all the desiderata is impossible, but counterfactual comparisons satisfy the most while absolute disclosure risk satisfies the fewest. Furthermore, we explain that many of the criticisms levied against differential privacy would be levied against any technology that is not equivalent to direct, unrestricted access to confidential data. More research is needed, but in the near term, the counterfactual approach appears best-suited for privacy versus utility analysis.

Health system strengthening: Integration of breast cancer care for improved outcomes.

The adoption of the goal of universal health coverage and the growing burden of cancer in low- and middle-income countries makes it important to consider how to provide cancer care. Specific interventions can strengthen health systems while providing cancer care within a resource-stratified perspective (similar to the World Health Organization-tiered approach). Four specific topics are discussed: essential medicines/essential diagnostics lists; national cancer plans; provision of affordable essential public services (either at no cost to users or through national health insurance); and finally, how a nascent breast cancer program can build on existing programs. A case study of Zambia (a country with a core level of resources for cancer care, using the Breast Health Global Initiative typology) shows how a breast cancer program was built on a cervical cancer program, which in turn had evolved from the HIV/AIDS program. A case study of Brazil (which has enhanced resources for cancer care) describes how access to breast cancer care evolved as universal health coverage expanded. A case study of Uruguay shows how breast cancer outcomes improved as the country shifted from a largely private system to a single-payer national health insurance system in the transition to becoming a country with maximal resources for cancer care. The final case study describes an exciting initiative, the City Cancer Challenge, and how that may lead to improved cancer services.

The Breast Health Global Initiative 2018 Global Summit on Improving Breast Healthcare Through Resource-Stratified Phased Implementation: Methods and overview.

BACKGROUND: The Breast Health Global Initiative (BHGI) established a series of resource-stratified, evidence-based guidelines to address breast cancer control in the context of available resources. Here, the authors describe methodologies and health system prerequisites to support the translation and implementation of these guidelines into practice. METHODS: In October 2018, the BHGI convened the Sixth Global Summit on Improving Breast Healthcare Through Resource-Stratified Phased Implementation. The purpose of the summit was to define a stepwise methodology (phased implementation) for guiding the translation of resource-appropriate breast cancer control guidelines into real-world practice. Three expert consensus panels developed stepwise, resource-appropriate recommendations for implementing these guidelines in low-income and middle-income countries as well as underserved communities in high-income countries. Each panel focused on 1 of 3 specific aspects of breast cancer care: 1) early detection, 2) treatment, and 3) health system strengthening. RESULTS: Key findings from the summit and subsequent article preparation included the identification of phased-implementation prerequisites that were explored during consensus debates. These core issues and concepts are key components for implementing breast health care that consider real-world resource constraints. Communication and engagement across all levels of care is vital to any effectively operating health care system, including effective communication with ministries of health and of finance, to demonstrate needs, outcomes, and cost benefits. CONCLUSIONS: Underserved communities at all economic levels require effective strategies to deploy scarce resources to ensure access to timely, effective, and affordable health care. Systematically strategic approaches translating guidelines into practice are needed to build health system capacity to meet the current and anticipated global breast cancer burden.

Optimisation of the continuum of supportive and palliative care for patients with breast cancer in low-income and middle-income countries: executive summary of the Breast Health Global Initiative, 2014.

Supportive care and palliative care are now recognised as critical components of global cancer control programmes. Many aspects of supportive and palliative care services are already available in some low-income and middle-income countries. Full integration of supportive and palliative care into breast cancer programmes requires a systematic, resource-stratified approach. The Breast Health Global Initiative convened three expert panels to develop resource allocation recommendations for supportive and palliative care programmes in low-income and middle-income countries. Each panel focused on a specific phase of breast cancer care: during treatment, after treatment with curative intent (survivorship), and after diagnosis with metastatic disease. The panel consensus statements were published in October, 2013. This Executive Summary combines the three panels' recommendations into a single comprehensive document covering breast cancer care from diagnosis through curative treatment into survivorship, and metastatic disease and end-of-life care. The recommendations cover physical symptom management, pain management, monitoring and documentation, psychosocial and spiritual aspects of care, health professional education, and patient, family, and caregiver education.

Self-Movement Screening using the Symmio Application is Reliable and Valid for Identifying Musculoskeletal Risk Factors.

Background: Musculoskeletal health problems are one of the greatest healthcare expenses in the United States but patient-driven screening procedures to detect risk factors do not exist. Hypothesis/Purpose: The purpose was to establish the inter-rater reliability of the Symmio Self-Screen application in untrained individuals and to investigate its accuracy to detect MSK risk factors such as pain with movement, movement dysfunction, and decreased dynamic balance. Study Design: Cross-Sectional. Methods: Eighty (42 male, 38 female) healthy individuals mean age 26.5 ± 9.4 participated in the study. The inter-rater reliability of Symmio application was established by comparing self-screen scores from untrained subjects with the results simultaneously determined by a trained healthcare provider. Each subject was evaluated for pain with movement, movement dysfunction, and deficits in dynamic balance by two trained evaluators who were blinded to the Symmio results. The validity of Symmio was determined by comparing self-screen performance dichotomized as pass or fail with the reference standard of pain with movement, failure on the Functional Movement Screen™, and asymmetry on the Y Balance Test-Lower Quarter™ using three separate 2x2 contingency tables. Results: The mean Cohen's kappa coefficient was 0.68 (95% CI, 0.47-0.87) and the absolute agreement was 89% between self-assessment of subjects and the observation of a trained healthcare provider. There were significant associations for the presence of pain with movement (p=0.003), movement dysfunction (p=0.001), and dynamic balance deficits (p=0.003) relative to poor Symmio performance. The accuracy of Symmio to identify pain with movement, movement dysfunction, and dynamic balance deficits were 0.74 (95% CI, 0.63-0.83), 0.73 (95% CI, 0.62-0.82), and 0.69 (95% CI, 0.57-0.79), respectively. Conclusions: The Symmio Self-Screen application is a reliable and feasible screening tool that can be used to identify MSK risk factors. Level of Evidence: Level 2.

HER1-ECD vaccination dispenses with emulsification to elicit HER1-specific anti-proliferative effects.

EGFR (HER1) highlights as one of the most relevant tumor associated antigen in epithelial malignant cells. Monoclonal antibodies and tyrosine kinase inhibitors against EGFR remain as the most advanced approaches in clinical trials. More recently, an active immunotherapy using the HER1 extracellular domain (ECD) adjuvated in very small size proteoliposomes (VSSP) and emulsified in Montanide ISA-51 demonstrated its strength to inhibit tumor cell line proliferation by arresting cells in G(0)/G(1) stage and induction of apoptosis. In this study, we present a simpler HER1-ECD-based formulation, which is lacking the oily component Montanide ISA-51. Generated antibodies following non-emulsive formulation immunization recognized membrane EGFR; avoid EGF and TGFalpha coupling to EGFR leading to a marked abrogation of EGFR phosphorylation levels. Non-emulsive formulation also arrests cell cycle in G(0)/G(1) stage, demonstrating it preserves previous formulation quality in a newer and simpler formulation.

Acute appendicitis in Amyand's hernia: ultrasound findings and histopathology correlation. A case report.

Amyand's hernia is an uncommon form of inguinal hernia. It represents <1% of all hernias and its complication with appendicitis is still rarer with 0.1-0.13% being reported. A 78-year-old woman was taken to the emergency room with pain in the right groin. The patient was assessed by ultrasound with the clinical suspicion of an inguinal hernia. We present the ultrasonographic features of appendicitis within an inguinal hernia sac. A tubular image that terminated in a blind-ended tip in the longitudinal plane and a target image on the cross-sectional plane were consistent with the sonographically demonstrated appendix. The diagnosis of Amyand's hernia is difficult in the clinical setting. The patient is frequently referred to surgery with the diagnosis of an incarcerated hernia. Ultrasound is a good imaging modality that detects and characterizes this uncommon condition.

Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Cuba.

The contribution of BRCA1 and BRCA2 to breast cancer incidence in Cuba has not yet been explored. In order to estimate the proportion of breast cancers due to BRCA1 and BRCA2 mutations in Cuba, and to identify possible Cuban founder mutations, we conducted a study of unselected breast cancer patients from Havana, Cuba. We enrolled 336 women with breast cancer from a large public hospital in the city. A family history of cancer was obtained from each patient and a blood sample was processed for DNA analysis. Mutations in BRCA1 and BRCA2 were sought using a combination of techniques, but all mutations were confirmed by direct sequencing. We were able to successfully complete testing on samples from 307 women. Among these, eight mutations were identified (seven in BRCA2 and one in BRCA1) representing 2.6% of the total, including 10% of familial cases and 10% of cases under age forty. One BRCA2 mutation (c.3394C > T) was found in two women, but no clear example of a founder mutation was identified. In summary, BRCA1 and BRCA2 mutations are not uncommon in Cuban women with breast cancer, but the absence of founder mutations precludes the development of a rapid and inexpensive clinical screening test.

La rehabilitación integral en pacientes post COVID-19

Introducción: El equipo de rehabilitación asume un papel importante en el manejo de secuelas que pueden derivarse de la COVID-19 por el virus SARS-CoV-2. Objetivo: Caracterizar a pacientes que han padecido la COVID-19 y relacionar las pautas terapéuticas en rehabilitación con variables de interés. Métodos: Se realizó un estudio descriptivo en el Policlínico Universitario Santa Clara, de enero a septiembre del año 2021. En la totalidad de pacientes 322 con diagnóstico confirmado de COVID-19, por la prueba de reacción en cadena de la polimerasa en tiempo real con examen negativo al egreso. Se estudiaron las variables: edad, sexo, comorbilidades, síntomas y presencia de complicaciones en el curso de la enfermedad, síntomas post COVID-19, pautas rehabilitadoras. Se mostraron distribuciones de frecuencias absolutas y relativas. En el análisis estadístico se utilizó la prueba de independencia basada en la distribución chi cuadrado. Se tuvo en cuenta consideraciones éticas. Resultados: Prevaleció el sexo masculino y el grupo de edad entre 18 a 59 años; la comorbilidad más frecuente fue la hipertensión arterial. En el curso de la enfermedad fue la tos el síntoma más frecuente y en la valoración post COVID-19 la debilidad muscular. Un porcentaje elevado de casos necesitó rehabilitación, ya sea domiciliaria o institucional. La necesidad de rehabilitación domiciliaria o institucional alcanzó mayor frecuencia ante la presencia de comorbilidades y complicaciones. Conclusiones: Las comorbilidades y complicaciones mostraron una relación estadísticamente significativa con las pautas terapéuticas.

Introduction: The rehabilitation team assumes an important role in the management of sequelae that may result from COVID-19 due to the SARS-CoV-2 virus. Objectives: To characterize patients who have suffered from COVID-19 and relate therapeutic guidelines in rehabilitation with variables of interest. Methods: A descriptive study at the Santa Clara University Polyclinic, from January to September 2021. In all patients (322) with a confirmed diagnosis for SARS-CoV-2, by the polymerase chain reaction test in time real with negative exam at discharge. The variables were studied: age, sex, comorbidities, symptoms and presence of complications in the course of the disease, post-COVID-19 symptoms, rehabilitation guidelines. Absolute and relative frequency distributions were shown. In the statistical analysis, the test of independence based on the chi-square distribution was used. Ethical considerations were taken into account. Results: The male sex and the age group between 18 to 59 years prevailed; the most frequent comorbidity was high blood pressure. During the course of the disease, cough was the most frequent symptom and in the post-COVID-19 assessment, muscle weakness. A high percentage of cases required rehabilitation, either home or institutional. The need for home or institutional rehabilitation was more frequent in the presence of comorbidities and complications. Conclusions: Comorbidities and complications showed a statistically significant relationship with therapeutic guidelines.

Treatment of NSCLC patients with an EGF-based cancer vaccine: report of a Phase I trial.

Epidermal Growth Factor (EGF) promotes tumor cell proliferation and survival upon binding to its receptor. We have developed a new active specific immunotherapy based on EGF deprivation. In the present paper, we show the results of a Phase I trial in 43 patients with advanced non-small cell lung cancer (NSCLC) who received the EGF vaccine. Patients who had already received first line therapy were randomized to receive a single or double dose of the EGF vaccine, weekly for four weeks and monthly thereafter. No significant toxicity was seen after vaccination. Adverse events consisted primarily of fever, chills, nausea, vomiting and flushing. Fifteen patients (39%) developed a good antibody response (GAR) against EGF. The geometric mean of the antibody titer was higher in the double dose group. EGF concentration was quantified in serum. An inverse correlation between anti-EGF antibody titers and EGF concentration was seen after immunization. Vaccinated patients achieved median survival times of 8.23 months from randomization. Patients who received the double dose of treatment showed a trend toward increased survival in comparison with patients who received the single dose. GAR and patients in whom the serum EGF decreased below the 168 pg/ml cut-off point had a significantly better survival when compared to poor responders or patients in which the EGF levels were not considerably reduced. Our results confirm the immunogenicity of the EGF vaccine in the treatment of patients with advanced stage NSCLC. Antibody titers and serum EGF levels appear to correlate with patient survival.

Relationship between IL-10 and tumor markers in breast cancer patients.

Tumor markers are expressed due to molecular alterations of the tumor cells, and we can relate them to the immune system to find new associations to improve prognosis. IL-10 inhibits the generation of immune responses at the tumor site. To determine IL-10 expression in the tumor microenvironment and to associate it with certain tumor markers, 27 breast cancer patients were monitored by immunohistochemistry. The results showed that 23 breast cancer samples exhibited a strong expression of IL-10. IL-10 was associated with some poor prognosis tumor makers. A direct association between IL-10, Bcl-2, and Bax was detected. The relationship between IL-10 and Bax was statistically significant (P=0.001). An inverse association of IL-10 with p53 was observed. IL-10 reflects a suppressive tumor microenvironment, and its relationship with apoptosis markers can suggest an increase in the aggressiveness of the tumor even if it still is at an early stage.

Evaluación de los resultados en el tratamiento de los pacientes con fracturas de pilón tibial / Outcomes assessment in the treatment of patients with tibial pylon fractures

RESUMEN Introducción: las fracturas de pilón tibial son un desafío para el cirujano y actualmente existe controversia en cuanto a su tratamiento. Objetivo: evaluar los resultados del tratamiento aplicado. Materiales y métodos: se realizó un estudio observacional, descriptivo, longitudinal, con el universo de estudio de todos los pacientes que fueron atendidos y tratados con fractura de pilón tibial desde el 1 de enero de 2015 al 31 de diciembre de 2016. Se seleccionó una muestra de 27 pacientes. Resultados: hubo un predominio del sexo masculino (78 %), y del grupo de edades de 40 a 49 años para ambos sexos (37 %). Prevalecieron las fracturas producidas por accidentes de tránsito, con 59 %. Las fracturas cerradas fueron las más representadas, con 78 %. El 67 % de los pacientes no presentaron lesiones asociadas y predominaron las fracturas tipo II en el 55 % del total. Se aplicó tratamiento quirúrgico a un 74 % y se logró la consolidación en un 78 % de los casos antes de las 16 semanas. Antes de las 20 semanas se le indicó el apoyo al 78 % de los casos. Se complicaron 13 pacientes, para un 48 % del total. A pesar de ello, como resultado final, fueron evaluados de excelente y bien el 63 % de los pacientes. Conclusiones: la fractura de pilón tibial constituye una lesión de muy difícil manejo para el cirujano traumatólogo de hoy (AU).

ABSTRACT Introduction: tibial pylon fractures are a challenge for the surgeon surgery and currently there is a controversy regarding their treatment. Objective: to assess the outcomes of the applied treatment. Materials and methods: an observational, descriptive, longitudinal study was carried out with the study universe of all the patients who were attended and treated with tibial pylon fracture from January 1st, 2015 to December 31st, 2016. A sample composed by 27 patients was chosen. Results: male sex (78 %) and both-sexes 40-49 age group (37 %) predominated. There was a predominance of fractures caused by traffic accidents with 59 %, being closed fractures the most represented ones, with 78 %. 67 % of the patients did not present associated injuries, being type II fractures predominant in 55 % of the total. 74 % of the cases underwent surgery, achieving consolidation in 78 % of the cases before 16 weeks. Before 20 weeks, 78 % of the cases were indicated to set on their foot, and 13 patients had complications, representing 48 % of the total. In spite of this, 63 % of the patients were evaluated as excellent and well as final outcome. Conclusions: the tibial pylon fracture is an injury of very difficult handling for the today's orthopedic surgeon (AU).

Historia de la Ortopedia y Traumatología en la provincia de Matanzas / History of Orthopedics and Traumatology in Matanzas Province

Introducción: El presente trabajo aborda la historia de la especialidad de Ortopedia y Traumatología desde el momento de su aparición en la provincia de Matanzas en el período pre revolucionario, hasta la actualidad. Objetivos: Exponer las evidencias históricas que muestran el derrotero de esta especialidad, y las figuras que jugaron y juegan un papel importante en la formación de especialistas. Métodos: Se utilizó el método de revisión documental sobre el tema, que contempló los documentos editados de 1941 al 2020. Se confeccionó un cuestionario para recoger la información aportada por los testigos entrevistados. Se revisaron los artículos publicados en la revista Médica que se encuentran en la Biblioteca Gener del Monte, de Matanzas (ejemplares únicos), así como otras investigaciones sobre la historia de la medicina matancera. Conclusiones: El esfuerzo desarrollado por la provincia desde el punto de vista asistencial, docente e investigativo ha contribuido a la preservación de la historia de la Ortopedia matancera y de sus actores para las actuales y futuras generaciones(AU)

Introduction: The present work addresses the history of the specialty of Orthopedics and Traumatology from the moment of its appearance in Matanzas province during the pre-revolutionary period, to the present day. Objectives: To show the historical evidence the historical evidence that displays the course of this specialty, and the personalities who played and play important roles in the training specialists. Methods: The document review method on the subject was used, considering the documents published from 1941 to 2020. A questionnaire was made to collect the information provided by the interviewed witnesses. The articles published in the Medical Journal found in Gener del Monte Library in Matanzas (single copies) were reviewed, as well as other investigations on the history of medicine in Matanzas. Conclusions: The effort established by the province, in care, teaching and research has contributed to the preservation of the history of Matanzas Orthopedics and its players for current and future generations(AU)

Evaluación del validismo posterior al tratamiento quirúrgico en fracturas del extremo proximal de fémur / Assessment of validism after surgical treatment in fractures of the femur proximal end

RESUMEN Introducción: la fractura de cadera es una de las causas más frecuentes de cirugía traumatológica. La selección del material de osteosíntesis constituye el objetivo fundamental en el tratamiento quirúrgico, lo que puede influir en el nivel de validismo alcanzado. Objetivo: evaluar el nivel de validismo en los pacientes intervenidos quirúrgicamente, con diferentes implantes según los diferentes tipos de fracturas del extremo proximal de fémur. Atendidos en el Hospital Provincial Clínico Quirúrgico "Comandante Faustino Pérez Hernández" de la provincia de Matanzas. Materiales y métodos: se realizó un estudio prospectivo, longitudinal donde se estudiaron todos aquellos pacientes con fractura de cadera. En el periodo comprendido desde el 1er de enero del 2016 al 31 de diciembre del 2017. Resultados: predominó el sexo femenino con un 60 % y el grupo de edades de 70 a 79 años para ambos sexos. Prevaleció la fractura extracapsular en un 74 %. El material de osteosíntesis más representado fue el clavo intramedular Gt y en las intracapsulares la prótesis simple. El tiempo quirúrgico se comportó con un tiempo menor a 2 h y el egreso antes de los 5 días. El 48,2 % de los pacientes fueron evaluados de bueno según nivel de validismo alcanzado posterior al tratamiento aplicado. Conclusiones: la fractura de cadera es propia de pacientes adultos mayores que sobrepasan los 65 años. La intervención quirúrgica de urgencia con una adecuada selección del método de osteosíntesis, disminuye un serio problema de salud en el contexto médico, social y epidemiológico cubano (AU).

ABSTRACT Introduction: hip fracture is one of the most frequent indications of trauma surgery. The choice of the osteosynthesis material is the main objective in the surgical treatment, which can influence the level of validity achieved. Objective: to assess the level of validism in patients who underwent surgery with different implants according to the different types of fracture of the proximal end of the femur in the Provincial Surgical Clinical Hospital Comandante Faustino Pérez Hernández of the province of Matanzas. Materials and methods: A prospective, longitudinal study was carried out in all patients with hip fracture in the period from January 1st 2016 to December 31st 2017. Results: female sex (60%) and the 70-79 age group for both sexes (36%) predominated. The extracapsular fracture prevailed with 74%. The most represented osteosynthesis material was the Gt intramedullary nail, and the simple prosthesis in the intracapsular ones. Surgical time was less than 2 hours and the patients were discharged before the 5th day. 48.2% of patients were evaluated as good according to the level of validism achieved after the applied treatment. Conclusions: hip fracture is proper of elder adult people aged more than 65 years. The emergency surgical intervention with an adequate choice of the osteosynthesis method, reduces a serious health problem in the Cuban epidemiological, social and medical context (AU).

Comportamiento de las lesiones traumáticas del anillo pélvico / Behavior of the traumatic lesions of the pelvic ring

RESUMEN Introducción: las lesiones traumáticas del anillo pélvico constituyen un desafío para los cirujanos ortopedistas por su alta morbimortalidad y las consecuencias que de ellas derivan. Objetivo: describir el comportamiento de variables demográficas y clínicas en los pacientes atendidos por lesiones traumáticas del anillo pélvico en el Hospital Universitario "Comandante Faustino Pérez Hernández" de Matanzas Materiales y Métodos: se realizó un estudio longitudinal prospectivo descriptivo de los pacientes ingresados en el servicio de ortopedia y traumatología por presentar lesiones traumáticas del anillo pélvico en dicho centro en el período comprendido de enero del 2009 a enero del 2019. Se seleccionaron variables demográficas y clínicas Resultados: el estudio incluyó a 48 pacientes. Predominó el sexo masculino 29 pacientes para un 60,4%, la edad de mayor frecuencia estuvo entre 31 a 50 años. Predominaron las fracturas tipo B con 24 pacientes para 50% y el tratamiento quirúrgico con 27 pacientes para 56,2%, dentro de las complicaciones inmediatas predominó el shock hipovolémico en 14 pacientes para 29.1%, en las tardías la sepsis superficial con 6 pacientes, 12.5%. Conclusiones: las lesiones traumáticas del anillo pélvico siempre deben ser tratadas como lesiones graves, por lo que deben ser valoradas de forma multidisciplinaria y apegados a protocolos de actuación, y con especialistas de alta experiencia profesional (AU).

SUMMARY Introduction: pelvic ring traumatic lesions are a challenge for orthopedic surgeons due to their high morbi-mortality and the consequences derived from them. Objective: to describe the behavior of clinical and demographic variables in patients cared due to pelvic ring traumatic lesions in the University Hospital "Comandante Faustino Perez Hernandez" of Matanzas. Method: a descriptive, prospective, longitudinal research was carried out in patients admitted to the Orthopedics and Traumatology Service of the before-named hospital for presenting pelvic ring traumatic lesions in the period from January 2009 until January 2019. Clinical and demographic variables were chosen. Results: the study included 48 patients. Male sex predominated, 29 patients, 60.4 %; the most frequent age ranged between 31 and 50 years. Type B fractures predominated with 24 patients and 50 %; surgical treatment also predominated with 27 patients and 56.2 %; among the immediate complications, hypovolemic shock predominated in 14 patients for 29.1 %; among the late ones, surface sepsis predominated with 6 patients, 12.5 %. Conclusions: pelvic ring traumatic lesions should be always treated like serious lesions; therefore they should be evaluated in a multidiscipline way, adhered to the intervention protocols, and by highly experienced professionals (AU).

Triple transferencia tendinosa en la parálisis radial alta. A propósito de un caso / Triple tendinous transference in high radial paralysis. Apropos of a case

RESUMEN La parálisis del nervio radial producida por lesiones a nivel del brazo es considerada una parálisis alta, y se caracteriza por presentar la muñeca y los dedos flexionados y el pulgar en aducción con imposibilidad para la extensión de los mismos (muñeca y dedos). Todos los autores coinciden en que, para la extensión de la muñeca, el músculo de elección a transferir es el pronador redondo para el segundo radial. Sin embargo, hay diversidad de criterios sobre la utilización del palmar mayor o del cubital anterior para el extensor común de los dedos, y del palmar menor para el extensor largo del pulgar. Se presentó el caso de un paciente de 31 años de edad, con antecedente de accidente de tránsito y diagnóstico de parálisis radial alta de 18 meses de evolución, en el que se decide tratamiento quirúrgico utilizando el músculo cubital anterior después de una rehabilitación exitosa, obteniéndose excelentes resultados (AU).

ABSTRACT The radial nerve paralysis produced by lesions at the level of the arm is considered a high paralysis, and is characterized by presenting the wrist and fingers flexed and the thumb in adduction with impossibility of extending them (wrist and fingers). All consulted authors agree that, for wrist extension, the elective muscle to transfer is the round pronator for the second radial. However, there are different criteria on the use of the palmar major or anterior ulnar for the common finger extender, and the palmar minor for the long thumb extender. We presented the case of a 31-year-old patient, with a history of traffic accident and diagnosis of 18-month high radial paralysis, in which surgical treatment using the anterior ulnar muscle after a successful rehabilitation was decided, obtaining excellent results (AU).

Influencia de los factores pronósticos en la rehabilitación de pacientes geriátricos con ictus isquémico / Influence of prognostic factors in the rehabilitation of geriatric patients with ischemic ictus

RESUMEN Fundamento: la enfermedad cerebrovascular es en la actualidad uno de los problemas de salud más importantes, tanto en países desarrollados como subdesarrollados. Objetivo: valorar el grado de independencia funcional alcanzada en el proceso de rehabilitación en pacientes geriátricos con ictus isquémico según los factores pronósticos presentes. Métodos: se realizó un estudio prospectivo en pacientes geriátricos en la sala de rehabilitación del policlínico Santa Clara de enero de 2017 a diciembre de 2018 con diagnóstico clínico y radiológico de ictus isquémico. El universo de estudio estuvo constituido por 31 pacientes, se identificaron los factores pronósticos y se aplicó el Índice de Barthel al inicio y final de realizar el tratamiento neurorehabilitador. En el análisis estadístico se utilizaron pruebas no paramétricas, independencia basada en la distribución chi cuadrado y para muestras relacionadas, homogeneidad marginal. Resultados: predominaron los pacientes con edad entre los 60 y 69 años del sexo masculino. Los factores pronósticos encontrados en mayor frecuencia fueron la afectación del hemisferio dominante, retracciones osteotendinosas, desarrollo psicológico negativista y la colaboración pasiva. Previo al tratamiento en pacientes con menos de dos factores pronósticos, predominó la dependencia leve y al final se igualan los dependientes leves e independientes, en los pacientes con dos o más factores, al inicio del tratamiento predominaron los dependientes moderados y al final los dependientes leves. Conclusiones: la rehabilitación neurológica mejoró en la independencia de las actividades de la vida diaria de los pacientes geriátricos con ictus isquémico, que se hace más evidente cuando este se asocia a menos de dos factores pronósticos.

ABSTRACT Background: cerebrovascular disease is currently one of the most important health problems, both in developed and underdeveloped countries. Objective: to value the grade of functional independence reached in the rehabilitation process in patient geriatrics with ischemic ictus according to the factors present presage. Methods: a prospective study was carried out in geriatric patients in the rehabilitation room of the Santa Clara Polyclinic from January 2017 to December 2018 with a clinical and radiological diagnosis of ischemic ictus. The study universe was constituted by 31 patients, the prognostic factors were identified and the Barthel Index was applied at the beginning and end of the neuro-rehabilitation treatment. In the statistical analysis, nonparametric tests were used. (Independence based on the Chi square distribution and for related samples, marginal homogeneity). Results: male patients with age between 60 and 69 years of age are predominant. The prognostic factors found most frequently were the involvement of the dominant hemisphere, osteotendinous retractions, negative psychological development and passive collaboration. Prior to treatment, in patients with less than two prognostic factors, mild dependence predominated and in the end mild and independent dependents are equalized; in patients with two or more factors, moderate dependents predominated at the start of treatment and mild dependents at the end. Conclusions: neurological rehabilitation improves independence in the activities of daily life of geriatric patients with ischemic ictus that becomes more evident when this is associated with less than two prognostic factors.

The cross-classified multilevel measurement model: an explanation and demonstration.

The link between the hierarchical generalized linear model (HGLM) and the Rasch model's parameterization has already been demonstrated by several researchers. Extensions have been described that include higher clustering levels to model more appropriately the contextual effects that are frequently encountered in educational research. However, pure hierarchies are relatively rare and instead cross-classified data structures are more frequently encountered. Cross-classified random effect modeling (CCREM) is still not commonly used. Use of CCREM in combination with the multilevel measurement model (MMM) has been recently introduced and is described further in the current study. Specifically, the link between the MMM and the CCREM MMM (termed "CCMMM" model) is provided. A dataset was simulated to demonstrate interpretation of the CCMMM model's parameters and to compare results under a CCMMM versus HGLM analysis. An Appendix is provided to demonstrate SAS GLIMMIX code used to estimate HGLM and CCMMM models' parameters.

A monoclonal antibody against NeuGc-containing gangliosides contains a regulatory idiotope involved in the interaction with B and T cells.

P3 (IgM-kappa) is a monoclonal antibody (mAb) reacting with N-glycolyl neuraminic acid (NeuGc)-containing gangliosides and sulfated glycolipids. To explore the nature of the idiotope defined by 1E10, we used a phage-displayed random peptide library. After three rounds of selection, seven different phagotopes were isolated. Noteworthy, all the sequences were found to bear the basic amino acid-rich motifs KPPR (3) or RRPR/K (4). This recursive selection of basic sequences by 1E10 mAb confirmed previous suggestions of the involvement of charged residues in the interaction between gamma-type Ab2 and P3 mAb. The binding of 1E10 to phage peptides representing each group was completely inhibited by P3 mAb. In addition, other Ab2 to P3 were able to recognize these peptides. Thus, phage peptides seem to be mimotopes of the idiotope recognized by anti-idiotypic antibodies in P3. Phage motifs were represented in the lineal sequence of P3's heavy chain H-CDR3 and a 14-mer peptide representing this region was able to specifically inhibit 1E10 binding to P3. Previous studies showed that P3's idiotype was autoimmunogenic and shared by antibodies with different specificities. Now, we demonstrated that P3 mAb is able to activate a network cascade involving autologous anti-idiotypic and anti-anti-idiotypic T cells. Thus, P3's idiotype fulfill the three criteria previously established to define a "regulatory idiotype". Particularly, data presented here revealed the immunodominance of the H-CDR3 of this mAb as a T cell epitope. Thus, H-CDR3 is simultaneously involved in the interaction of P3 mAb with anti-idiotypic B and T cells, behaving as a potential regulatory idiotope.