Detalhe da pesquisa
1.
Multivalent pyrrolidines acting as pharmacological chaperones against Gaucher disease.
Bioorg Chem
; 146: 107295, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38513326
2.
Exploring the plasticity of the InhA substrate-binding site using new diaryl ether inhibitors.
Bioorg Chem
; 143: 107032, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38128204
3.
IDO1 and TDO inhibitory evaluation of analogues of the marine pyrroloiminoquinone alkaloids: Wakayin and Tsitsikammamines.
Bioorg Med Chem Lett
; 40: 127910, 2021 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33711443
4.
N,O-Dialkyl deoxynojirimycin derivatives as CERT START domain ligands.
Bioorg Med Chem Lett
; 30(2): 126796, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31757669
5.
Concise asymmetric synthesis of new enantiomeric C-alkyl pyrrolidines acting as pharmacological chaperones against Gaucher disease.
Org Biomol Chem
; 18(39): 7852-7861, 2020 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32975266
6.
First triclosan-based macrocyclic inhibitors of InhA enzyme.
Bioorg Chem
; 95: 103498, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31855823
7.
Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors.
Molecules
; 24(2)2019 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30669468
8.
Iminosugar-based ceramide mimicry for the design of new CERT START domain ligands.
Bioorg Med Chem
; 25(6): 1984-1989, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28237558
9.
Asymmetric Synthesis and Binding Study of New Long-Chain HPA-12 Analogues as Potent Ligands of the Ceramide Transfer Protein CERT.
Chemistry
; 22(19): 6676-86, 2016 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27031925
10.
The CERT antagonist HPA-12: first practical synthesis and individual binding evaluation of the four stereoisomers.
Bioorg Med Chem
; 23(9): 2004-9, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25818765
11.
Design of granulatimide and isogranulatimide analogues as potential Chk1 inhibitors: Study of amino-platforms for their synthesis.
Bioorg Med Chem
; 22(17): 4961-7, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25047935
12.
Phenyl dialkynylcarbinols, a Bioinspired Series of Synthetic Antitumor Acetylenic Lipids.
J Med Chem
; 66(20): 13918-13945, 2023 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37816126
13.
Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA.
Eur J Med Chem
; 259: 115646, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37482022
14.
In vitro toxicological effects of estrogenic mycotoxins on human placental cells: structure activity relationships.
Toxicol Appl Pharmacol
; 259(3): 366-75, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22310176
15.
Isolation and identification of ten new sildenafil derivatives in an alleged herbal supplement for sexual enhancement.
J Pharm Biomed Anal
; 191: 113482, 2020 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32898728
16.
Modification of endothelial nitric oxide synthase by 4-oxo-2(E)-nonenal(ONE) in preeclamptic placentas.
Free Radic Biol Med
; 141: 416-425, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31323312
17.
Hemisynthesis, Antitumoral Effect, and Molecular Docking Studies of Ferutinin and Its Analogues.
Chem Biol Drug Des
; 87(3): 382-97, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26432755
18.
Pyrrolidinone and pyrrolidine derivatives: Evaluation as inhibitors of InhA and Mycobacterium tuberculosis.
Eur J Med Chem
; 123: 462-475, 2016 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27490025
19.
Synthesis and in vitro antiproliferative activity of amido and amino analogues of the marine alkaloid isogranulatimide.
ChemMedChem
; 10(4): 607-9, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25735892
20.
Design, synthesis and evaluation of new GEQ derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth.
Eur J Med Chem
; 101: 218-35, 2015 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26142487