RESUMO
Ten 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates were synthesized and evaluated for antitumor activity. The 2-phenoxyethyl ester exhibited activity against P-388 lymphocytic leukemia, and the n-butyl and n-pentyl esters exhibited activity against L-1210 lymphoid leukemia in initial screening tests.
Assuntos
Antineoplásicos/síntese química , Clorambucila/análogos & derivados , Animais , Antineoplásicos/farmacologia , Fenômenos Químicos , Química , Clorambucila/síntese química , Clorambucila/farmacologia , Clorambucila/uso terapêutico , Leucemia L1210/tratamento farmacológico , Leucemia P388/tratamento farmacológico , Leucemia Experimental/tratamento farmacológico , Neoplasias Experimentais/tratamento farmacológicoRESUMO
Ten 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates were synthesized and evaluated for antitumor activity. The 2-phenoxyethyl ester exhibited activity against P-388 lymphocytic leukemia, and the n-butyl and n-pentyl esters exhibited activity against L-1210 lymphoid leukemia in initial screening tests.
RESUMO
In science education, inquiry-based approaches to teaching and learning provide a framework for students to building critical-thinking and problem-solving skills. Teacher professional development has been an ongoing focus for promoting such educational reforms. However, despite a strong consensus regarding best practices for professional development, relatively little systematic research has documented classroom changes consequent to these experiences. This paper reports on the impact of sustained, multiyear professional development in a program that combined neuroscience content and knowledge of the neurobiology of learning with inquiry-based pedagogy on teachers' inquiry-based practices. Classroom observations demonstrated the value of multiyear professional development in solidifying adoption of inquiry-based practices and cultivating progressive yearly growth in the cognitive environment of impacted classrooms.
Assuntos
Docentes , Neurociências/educação , Aprendizagem Baseada em Problemas , Ciência/educação , Ensino , Currículo/estatística & dados numéricos , Avaliação Educacional/estatística & dados numéricos , Docentes/estatística & dados numéricos , Humanos , Conhecimento , Aprendizagem Baseada em Problemas/estatística & dados numéricos , Ensino/estatística & dados numéricosAssuntos
Antineoplásicos/síntese química , Compostos de Mostarda Nitrogenada/síntese química , Amidas/síntese química , Amidas/uso terapêutico , Animais , Antineoplásicos/uso terapêutico , Butiratos/síntese química , Butiratos/uso terapêutico , Carcinoma , Carcinoma 256 de Walker/tratamento farmacológico , Linhagem Celular , Humanos , Leucemia L1210/tratamento farmacológico , Leucemia Experimental/tratamento farmacológico , Neoplasias Bucais , Compostos de Mostarda Nitrogenada/uso terapêutico , Espectrofotometria InfravermelhoAssuntos
Antineoplásicos/síntese química , Óxidos P-Cíclicos/síntese química , Dioxinas/síntese química , Animais , Antineoplásicos/uso terapêutico , Carcinoma 256 de Walker/tratamento farmacológico , Fenômenos Químicos , Química , Óxidos P-Cíclicos/uso terapêutico , Dioxinas/uso terapêutico , Raios Infravermelhos , Leucemia L1210/tratamento farmacológico , Métodos , EspectrofotometriaRESUMO
This retrospective analysis evaluates the effect of intravenously administered immunoglobulin against infections occurring during bone marrow depression after cancer chemotherapy in 85 children with leukemia and lymphoma. There was no statistical difference between patients with and without immunoglobulin administration neither when immunoglobulins were used prophylactically nor therapeutically in addition to antibodies during episodes of infection. Duration of fever, duration of antibiotic therapy, maximum of temperature, white blood cell counts, and kind of infections were comparable in 84 fever episodes in patients who had received immunoglobulin therapeutically and 69 fever episodes in patients who had not. This study supports the aspect that immunoglobulin administration does not have preventive or therapeutic efficacy on infections during cancer chemotherapy in children.