Detalhe da pesquisa
1.
Cooperation Between Distinct Cancer Driver Genes Underlies Intertumor Heterogeneity in Hepatocellular Carcinoma.
Gastroenterology
; 159(6): 2203-2220.e14, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32814112
2.
Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2.
EMBO J
; 34(13): 1773-85, 2015 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25979827
3.
Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns.
Genome Res
; 20(7): 972-80, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20488932
4.
PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib.
Sci Rep
; 12(1): 12501, 2022 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35864202
5.
The complex role of EZH2 in the tumor microenvironment: opportunities and challenges for immunotherapy combinations.
Future Med Chem
; 12(15): 1415-1430, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32723083
6.
Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.
PLoS Biol
; 4(8): e242, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16802858
7.
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
J Med Chem
; 61(3): 650-665, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29211475
8.
Drosophila nipped-B protein supports sister chromatid cohesion and opposes the stromalin/Scc3 cohesion factor to facilitate long-range activation of the cut gene.
Mol Cell Biol
; 24(8): 3100-11, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15060134
9.
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
J Med Chem
; 59(18): 8306-25, 2016 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27512831
10.
Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth.
Oncotarget
; 6(5): 2928-38, 2015 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25671303
11.
Methylation Abnormalities in Mammary Carcinoma: The Methylation Suicide Hypothesis.
J Cancer Ther
; 5(14): 1311-1324, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25960928
12.
Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
J Med Chem
; 59(24): 11196, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27936698
13.
Epigenetic reprogramming in solid tumors: therapeutic implications of EZH2 gain-of-function mutations.
Epigenomics
; 7(5): 687-90, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26317265
14.
Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells.
Chromosoma
; 117(1): 51-66, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17909832
15.
Large-scale structure of genomic methylation patterns.
Genome Res
; 16(2): 157-63, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16365381
16.
Computational prediction of methylation status in human genomic sequences.
Proc Natl Acad Sci U S A
; 103(28): 10713-6, 2006 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-16818882