Detalhe da pesquisa
1.
Cystine-glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity.
Proc Natl Acad Sci U S A
; 116(19): 9533-9542, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31019077
2.
Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors.
BMC Genomics
; 21(1): 2, 2020 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31898484
3.
Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1.
J Pharmacokinet Pharmacodyn
; 47(5): 513-526, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32710210
4.
Assessing Reuse of Hypodermic Needles in Mice by means of Digital Imaging, Photomicrography, Bacterial Culture, Analysis of Nest Building, and Animal Vocalization.
J Am Assoc Lab Anim Sci
; 62(3): 205-211, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36990673
5.
Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity.
Mol Cancer Ther
; 22(2): 254-263, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36722141
6.
Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade.
Mol Cancer Ther
; 21(9): 1462-1472, 2022 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35793468
7.
Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft model.
MAbs
; 13(1): 1958662, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34347577
8.
Preclinical Evaluation of 89Zr-Df-IAB22M2C PET as an Imaging Biomarker for the Development of the GUCY2C-CD3 Bispecific PF-07062119 as a T Cell Engaging Therapy.
Mol Imaging Biol
; 23(6): 941-951, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34143379
9.
Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia.
Clin Cancer Res
; 27(2): 622-631, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33148666
10.
Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors.
MAbs
; 13(1): 1850395, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33459147
11.
2-Aryl-4,5,6,7-tetrahydro-1,3-benzothiazol-7-ols as a class of antitumor agents selectively active in securin(-/-) cells.
Bioorg Med Chem Lett
; 20(13): 3903-5, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20627558
12.
Anti-tumor immunity influences cancer cell reliance upon ATG7.
Oncoimmunology
; 9(1): 1800162, 2020 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32923161
13.
PF-06804103, A Site-specific Anti-HER2 Antibody-Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers.
Mol Cancer Ther
; 19(10): 2068-2078, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32747418
14.
A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers.
Clin Cancer Res
; 26(9): 2188-2202, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31996389
15.
Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1).
Mol Cancer Ther
; 17(1): 243-253, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29054985
16.
A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions.
Sci Transl Med
; 9(372)2017 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28077676
17.
Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase.
Cancer Res
; 64(11): 3958-65, 2004 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15173008
18.
Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2).
J Med Chem
; 46(1): 49-63, 2003 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-12502359
19.
Explant-cell culture of primary mammary tumors from MMTV-c-Myc transgenic mice.
In Vitro Cell Dev Biol Anim
; 40(1-2): 14-21, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15180438
20.
Advances in patient-derived tumor xenografts: from target identification to predicting clinical response rates in oncology.
Biochem Pharmacol
; 91(2): 135-43, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24950467