Upper respiratory tract microbiome profiles in SARS-CoV-2 Delta and Omicron infected patients exhibit variant specific patterns and robust prediction of disease groups.

IMPORTANCE: The role of the upper respiratory tract (URT) microbiome in predicting lung health has been documented in several studies. The dysbiosis in COVID patients has been associated with disease outcomes by modulating the host immune system. However, although it has been known that different SARS-CoV-2 variants manifest distinct transmissibility and mortality rates in human populations, their effect on the composition and diversity of the URT microbiome has not been studied to date. Unlike the older variant (Delta), the newer variant (Omicron) have become more transmissible with lesser mortality and the symptoms have also changed significantly. Hence, in the present study, we have investigated the change in the URT microbiome associated with Delta and Omicron variants and identified variant-specific signatures that will be useful in the assessment of lung health and can be utilized for nasal probiotic therapy in the future.

Epilepsy awareness among parents of school children--a municipal survey.

A pilot study was undertaken to assess the knowledge, attitude and practice of parents of school-going children in a semi-urban municipal area of Bengal. An open-ended questionnaire with 14 questions were put in local language. A total of 1068 parents were interviewed with 76.9% males and 23.1% females. Most of them (60.7%) having an educational level above primary but below higher secondary school level; 41.4% surveyed believe epilepsy is caused by an infection and 40.8% have the idea that it is contagious too; 80.3% have the idea that epilepsy can be treated but 7.3% interviewed carry the idea that it cannot be treated at all. Only 35.9% responders are ready to allow an epileptic child to attend school and sit together with other children. In terms of first-aid management only 36.6% mentioned some useful first-aid measure. The general public attitude is reflected in this study. False belief and negative attitude leads to barrier in children education. Larger and comprehensive community-based educational programme is very much essential to bring about a change in negative attitude towards epilepsy.