Association of a single nucleotide polymorphism in pregnancy-associated plasma protein-A2 with developmental dysplasia of the hip: a case-control study.

Developmental dysplasia of the hip (DDH), previously known as congenital hip dislocation, is a frequently disabling condition characterized by premature arthritis in later life. Genetic influence on DDH has been long known, but is still poorly understood. Previously, we have performed a genome-wide linkage scan with Affymetrix 10K genechip for a four-generation Chinese family, which included 19 healthy members and five patients with DDH. Parametric and nonparametric multipoint linkage analyses were carried out with Genespring GT v.2.0 software, and the logarithm of odds (LOD) score and nonparametric linkage (NPL) score were calculated. For parametric linkage analysis, an assuming autosomal recessive trait was used with full penetrance, and Affymetrix "Asian" allele frequencies. The NPL score of 2.698 (P=0.0156) and LOD score of 2.119 (θ=0) were obtained on chromosome 1q25.2a for one marker (rs726252). The single nucleotide polymorphism (SNP) rs726252 locates in the region of fifth intron of pregnancy-associated plasma protein-A2 (PAPPA2). Although neither LOD nor NPL scores of rs726252 has exceeded 3.0, several researches have demonstrated that PAPPA2 have important consequences for the development of the fetus and normal postnatal growth. To further evaluate this possible association, in the present study, we examined the genetic association of rs726252 in PAPPA2 gene with sporadic DDH in Han Chinese population using case-control study, including 310 patients with sporadic DDH and 487 control subjects, and found a significant association between PAPPA2 and DDH.

NiP/CuO composites: Electroless plating synthesis, antibiotic photodegradation and antibacterial properties.

This work reports a simple method to prepare nickel-phosphorus (Ni-P) alloy modified CuO (Ni-P/CuO) composite, which shows excellent performance in terms of photodegradation antibiotics, particularly regarding the antibacterial properties. The Ni-P/CuO composites were prepared via two steps. The first step was to produce CuO by the hydrothermal method and the second step was to grow Ni-P in-situ on the surface of CuO through electroless plating. After loading of Ni-P, the photocatalytic activity of CuO for the decomposition of antibiotics is significantly increased under visible light irradiation. The photocatalytic activity of Ni-P/CuO with 4 wt% Ni-P loading is 25 times higher than that of CuO. Compared with CuO, the antibacterial activity of Ni-P/CuO with 4 wt% Ni-P loading against Escherichia coli is strongly increased. Based on the photoluminescence and photocurrent measurements of CuO and Ni-P/CuO, Ni-P cocatalyst improves the separation and transfer of the photogenerated charge in CuO, and enhances the photocatalytic activity of antibacterial performance. This work reveals that using Ni-P as the cocatalyst can strengthen the photocatalytic performance of CuO, which has great application potential in water purification and antibacterial treatments.