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1.
BMC Med Educ ; 21(1): 63, 2021 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-33468117

RESUMO

BACKGROUND: Most studies evaluating career aspirations among gender are performed in Anglo-Saxon countries. Two recent French studies looked at the career choice of residents in obstetrics & gynecology. It seemed useful to us to broaden this questioning to other specialties, by proposing a study to all residents in the same Faculty. The objective of our study was to describe residents' career aspirations and possible barriers according to gender. METHODS: Declarative cross-sectional survey, using questionnaires sent by email to the specialty residents of the Faculty of Medicine of Lille (France). An analysis by specialty group (i.e., medicine, surgery, obstetrics & gynecology, and anesthesia & resuscitation) and a comparison of the results according to gender were performed. RESULTS: Of the 1384 specialty residents currently in training, 462 answered the questionnaire (33.38%), among whom 289 women and 173 men (average age = 27.08 ± 0.091 years). Seventeen women (5.9%) were currently considering a university hospital career versus 37 men (21.4%) (p = 0.001). Gender analysis made it possible to identify obstacles to engaging in a university career: lacking a female model, more frequent doubting the ability to undertake this type of career among women (61.6%) than men (35.3%) (p < 0.001), and gender discrimination felt in the workplace for 51.6% of women (versus 7.5% of men, p < 0.001). Subgroup analysis showed specificities related to each specialty. CONCLUSIONS: Few residents plan to embark upon a university hospital career, let alone female residents. There are considerations specific to each specialty and marked gender differences regarding career aspirations. Many features have been identified as obstacles to access to university hospital positions for women. It is important to develop strategies to remove these barriers and enable women to pursue such university careers. TRIAL REGISTRATION: Not applicable (no intervention).


Assuntos
Internato e Residência , Medicina , Adulto , Escolha da Profissão , Estudos Transversais , Feminino , França , Humanos , Masculino , Inquéritos e Questionários
2.
Hum Reprod ; 33(3): 411-415, 2018 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-29315418

RESUMO

STUDY QUESTION: What are the fertility outcomes in women wishing to conceive after experiencing a severe complication from surgical removal of colorectal endometriosis? SUMMARY ANSWER: The pregnancy rate (PR) among women who wished to conceive after a severe complication of surgery for colorectal endometriosis was 41.2% (spontaneously for 80%, after ART procedure for 20%). WHAT IS KNOWN ALREADY: While the long-term benefit of surgery on pain and quality of life is well documented for women with colorectal endometriosis, it exposes women to the risk of severe complications. However, little is known about fertility outcomes in women experiencing such severe postoperative complications. STUDY DESIGN, SIZE, DURATION: This retrospective cohort study included women who experienced a severe complication after surgery for colorectal endometriosis between January 2004 and June 2014, and who wished to conceive. A total of 53 patients met the inclusion criteria. The fertility outcome was available for 48 women, who were therefore included in the analysis. The median follow-up was 5 years. PARTICIPANTS/MATERIALS, SETTING, METHODS: All the women underwent complete removal of colorectal endometriosis. Postoperative severe complications were defined as grades III-IV of the Clavien-Dindo classification. Fertility outcomes, PR and cumulative pregnancy rate (CPR), were estimated. MAIN RESULTS AND THE ROLE OF CHANCE: Most women experienced a grade IIIb complication (83.3%). Of 48 women, 20 became pregnant (overall PR: 41.2%); spontaneously for 16 (80%) and after ART procedure for 4 (20%). The median interval between surgery and first pregnancy was 3 years. The live birth rate was 14/48 (29.2%). The 5-year CPR was 46%. A lower CPR was found for women who experienced anastomotic leakage (with or without rectovaginal fistula) (P = 0.02) or deep pelvic abscess (with or without anastomotic leakage) (P = 0.04). LIMITATIONS REASONS FOR CAUTION: Due to a lack of information, no sub-analysis was done to investigate other parameters potentially impacting fertility outcomes. WIDER IMPLICATIONS OF THE FINDINGS: The PR for our population was slightly lower to that observed in the literature for women who experience such surgery without consideration for the occurrence of complications. However, 'severe complications' covers a range of conditions which are likely to have a very different impacts on fertility. Even if the PR and CPR appear satisfactory, septic complications can negatively impact fertility outcomes. Rapid ART may be a good option for these patients. STUDY FUNDING/COMPETING INTEREST(S): No funding was required for the current study. Pr H. Roman reported personal fees from Plasma Surgical Inc. (Roswell, GA, USA) for participating in a symposium and a masterclass, in which he presented his experience in the use of PlasmaJet®. None of the other authors declared any conflict of interest. TRIAL REGISTRATION NUMBER: N/A.


Assuntos
Doenças do Colo/cirurgia , Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos , Endometriose/cirurgia , Fertilidade/fisiologia , Infertilidade Feminina/etiologia , Complicações Pós-Operatórias/fisiopatologia , Adulto , Feminino , Humanos , Infertilidade Feminina/fisiopatologia , Nascido Vivo , Gravidez , Taxa de Gravidez , Qualidade de Vida , Estudos Retrospectivos , Adulto Jovem
3.
Int Urogynecol J ; 26(4): 497-504, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25227746

RESUMO

INTRODUCTION AND HYPOTHESIS: We created a pregnant woman pelvic model to perform a simulation of delivery to understand the pathophysiology of urogenital prolapse by studying the constraints on the pelvic components (muscles, ligaments, pelvic organs) during childbirth. These simulations will also provide valuable tools to understand and teach obstetrical mechanics. METHODS: We built a numerical model of the pelvic system from a term pregnant woman, using the finite element method on a mesh built from magnetic resonance images of a nulliparous pregnant woman. Mechanical properties of pelvic tissues already determined by the team were adapted to account for pregnancy. RESULTS: The system allows delivery to be simulated. When a fetal head at the 50th percentile for the term goes through the pelvic system, uterosacral ligaments undergo a deformation of around 30 %. Uterosacral ligaments are the major pelvic sustaining structures, their lesion may be a potential cause of urogenital prolapse. We built a model of childbirth as a function of pregnancy term by varying volumes of fetal head and uterus. The impact on uterosacral ligaments is higher when the fetal head is larger. CONCLUSIONS: Our modelling is rather complete considering that it involves many organs including ligaments. It allows us to analyse the effect of childbirth on uterosacral ligaments and to understand how they impact on pelvic statics. First results are promising, but optimisation and future simulations will be needed. We also plan to simulate various delivery scenarios (cephalic, breech presentation, instrumental extraction), which will be useful to study perineal lesions and also to teach obstetrical mechanics.


Assuntos
Cabeça/anatomia & histologia , Ligamentos/fisiologia , Modelos Biológicos , Pelve/fisiologia , Gravidez/fisiologia , Nascimento a Termo/fisiologia , Fenômenos Biomecânicos , Simulação por Computador , Feminino , Feto/anatomia & histologia , Análise de Elementos Finitos , Humanos , Tamanho do Órgão , Prolapso de Órgão Pélvico/etiologia
4.
Int Urogynecol J ; 24(1): 105-12, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22707008

RESUMO

INTRODUCTION AND HYPOTHESIS: Three-dimensional modeling of feminine pelvic mobility is difficult because the sustaining system is not well understood and ligaments are especially difficult to identify on imaging. METHODS: We built a 3-D numerical model of the pelvic cavity, based on magnetic resonance (MR) images and knowledge about anatomy and validated it systematically. RESULTS: The quantitative results of this model allow for the non-destructive localization of the structures involved in pelvic statics. With a better configuration of the functional pelvis and topological criteria, we can obtain a coherent anatomical and functional model. CONCLUSIONS: This model is the first step in developing a tool to localize and characterize pelvic imbalance in patients.


Assuntos
Imageamento Tridimensional , Imageamento por Ressonância Magnética , Pelve/anatomia & histologia , Fenômenos Biomecânicos , Feminino , Análise de Elementos Finitos , Humanos , Ligamentos/anatomia & histologia , Ligamentos/fisiologia , Pelve/fisiologia , Adulto Jovem
5.
Int Urogynecol J ; 2013 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-23958831

RESUMO

INTRODUCTION AND HYPOTHESIS: Genital prolapse remains a complex pathological condition. Physiopathology remains poorly understood, aetiology is multi-factorial, surgery is not always satisfying, as the rate of relapse cannot be overlooked. More over a good anatomical result will not always guarantee functional satisfaction. The aim of our study is to have a better understanding of the involvement of uterine ligaments in pelvic statics via 3D simulation. METHODS: Simulation of pelvic mobility is performed with a validated numerical model in a normal situation (standing up to lying down) or induced pathological ones where parts of the constitutive elements of the model are virtually "cut" independently. Displacements are then discussed. RESULTS: Numerical results have been compared with dynamic MRI for two volunteers. Dynamic sequences had 90 images, and 180 simulations have been validated. Results are coherent with clinical data and the literature, thus validating our mechanical approach. Uterine ligaments are involved in pelvic statics, but their lesions are not sufficient to generate a genital prolapse. Round ligaments play a part in uterine orientation; the utero-sacral ligaments support the uterus when standing up. CONCLUSIONS: Pelvic normal and pathological mobility study via modelling and 3D simulation is a new strategy in understanding the complex multifactorial physiopathology of genital prolapse. This approach must be validated in a larger series of patients. Nevertheless, pelvic ligaments seem to play an important role in statics, especially, in agreement with a literature survey, utero-sacral ligaments in a standing position.

6.
Gynecol Obstet Fertil Senol ; 51(9): 393-399, 2023 09.
Artigo em Francês | MEDLINE | ID: mdl-37295716

RESUMO

OBJECTIVES: To evaluate the use of simulation among French Obstetrics and Gynecology residency programs. METHODS: A survey was conducted with all 28 French residency program directors. The questionnaire covered equipment and human resources, training programs, types of simulation tools and time spent. RESULTS: Of the cities hosting a residency program, 93% (26/28) responded regarding equipment and human resources, and 75% (21/28) responded regarding training program details. All respondents declared having at least one structure dedicated to simulation. A formal training program was reported by 81% (21/26) of cities. This training program was mandatory in 73% of the cases. There was a median number of seven senior trainers involved, three of whom had received a specific training in medical education. Most of declared simulation activities concerned technical skills in obstetrics and surgery. Simulations to practice breaking bad news were offered by 62% (13/21) of cities. The median number of half-days spent annually on simulation training was 55 (IQR: 38-83). CONCLUSION: Simulation training is now widely available among French residency programs. There remains heterogeneity between centers regarding equipment, time spent and content of simulation curricula. The French College of Teachers of Gynecology and Obstetrics has proposed a roadmap for the content of simulation-based training based on the results of this survey. An inventory of all existing "train the trainers" simulation programs in France is also provided.


Assuntos
Ginecologia , Internato e Residência , Obstetrícia , Treinamento por Simulação , Feminino , Gravidez , Humanos , Obstetrícia/educação , Ginecologia/educação , Inquéritos e Questionários
7.
Gynecol Obstet Fertil Senol ; 50(1): 69-74, 2022 Jan.
Artigo em Francês | MEDLINE | ID: mdl-34656789

RESUMO

AIM: Endometriosis is a disabling gynecological pathology. Couples who face it frequently encounter sexual difficulties related to dyspareunia. This study aims to understand the sexual experiences of endometriosis patients and their partners. METHODS: A total of 13 patients and 13 partners were interviewed prior to surgery. Semi-structured interviews were conducted separately and explored their sexual experiences. The interviews were transcribed verbatim and analyzed using content analysis. RESULTS: Both members of the couple reported pain during intercourses; decreased sexual desire; adaptation during sexual intercourses; communication about sexuality, which can be either open or a source of conflict, and the search for explanations for endometriosis. As for the emotional sphere, patients report anticipatory anxiety while partners report frustration and hope. CONCLUSION: These couples are in difficulty regarding sexuality, it is necessary to take care of both members of the couple and to encourage communication between them.


Assuntos
Dispareunia , Endometriose , Dispareunia/etiologia , Endometriose/complicações , Feminino , Humanos , Comportamento Sexual/psicologia , Parceiros Sexuais/psicologia , Sexualidade/psicologia
8.
Gynecol Obstet Fertil Senol ; 49(11): 823-829, 2021 Nov.
Artigo em Francês | MEDLINE | ID: mdl-33933673

RESUMO

OBJECTIVES: Communication breakdown is one of the main causes of adverse events in clinical routine. The main objective of this study was to assess whether a short training course on medical communication based on the situation-background-assessment-recommendation (SBAR) tool improved the quality of communication in clinical practice. METHODS: Interventional study, conducted at the Jeanne de Flandre maternity unit (Lille University Hospital, France) between January 2017 and December 2019. The training sessions lasted 1 hour and consisted of a theoretical part, based on the SBAR tool, and of a practical part (video-stimulated recall and role-play case scenarios). The main outcome measure was the evaluation of the quality of the telephone calls made by a caregiver to the on-call doctor, using a questionnaire completed before (Q1) and remotely from training (Q2). RESULTS: One hundred and twenty health professionals were trained (n=120). Following the trainings, there was an improvement in communication in the short term, whether in terms of relevance (64.9 vs. 52.6, P<0.001) or conciseness of the message (36.9 vs. 32.2, P<0.001), but also in terms of long-term in a real clinical situation (Q2: 3.9 vs. Q1: 3.0, P<0.001). Finally, 81% of participants were satisfied with the training. CONCLUSIONS: Short training sessions on communication based on the SBAR tool appeared to improve participants' knowledge and skills in the short-term, but also in the longer term in a real clinical situation.


Assuntos
Cuidadores , Médicos , Comunicação , Feminino , França , Humanos , Gravidez , Inquéritos e Questionários
9.
J Gynecol Obstet Hum Reprod ; 50(3): 101836, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32590111

RESUMO

INTRODUCTION: The number of requests for Essure removal has grown continually over recent years. The objective is to describe the symptoms reported after Essure sterilization, methods of removal and results. MATERIAL AND METHODS: Retrospective and single-centre cohort (Regional university hospital of Lille, France) was conducted. All women, having consulted from December 2016 to February 2019 for symptoms related to Essure insertion, were included. All the symptoms were noted. A second group was created that included patients who underwent Essure removal to evaluate the benefits of surgery on these symptoms. RESULTS: The study included 98 patients. Most frequent symptoms were musculoskeletal pain (75 %), asthenia (63 %) and pelvic pain (55 %). Fifty-nine patients (60 %) underwent surgery. Surgery appeared beneficial with reduction of symptoms in 60 % of these patients, complete resolution in 33 % and no reduction of symptoms in 7%. Many symptoms were relieved by surgery with an overall decline of 96 % in menorrhagia, 94 % in metrorrhagia and 93 % in dyspareunia. However, other symptoms were not relieved by surgery like 100 % of sleep disorders, 70 % of abdominal pain cases and 57 % of memory impairment cases. CONCLUSION: Symptoms related to Essure insertion are numerous. Although surgery appears beneficial, some adverse effects remain. Therefore, a preoperative aetiologic assessment and information about risk of surgery failure are important.


Assuntos
Histerectomia , Salpingectomia , Esterilização Tubária/efeitos adversos , Esterilização Tubária/instrumentação , Adulto , Astenia/etiologia , Astenia/cirurgia , Estudos de Coortes , Feminino , Humanos , Pessoa de Meia-Idade , Dor Musculoesquelética/etiologia , Dor Musculoesquelética/cirurgia , Dor Pélvica/etiologia , Dor Pélvica/cirurgia , Estudos Retrospectivos , Esterilização Tubária/métodos , Resultado do Tratamento
10.
J Gynecol Obstet Hum Reprod ; 50(6): 101884, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32745640

RESUMO

BACKGROUND: Labia minora reduction is a surgery in the rise. Surgeons are left with a large choice of described techniques yet there is a paucity of visual data to guide surgeons through this procedure. Also, many gynecologic surgeons are reluctant to perform this operation emphasizing potential complications. TECHNIQUE: We present a step by step visual support of a wedge resection technique. EXPERIENCE: This technique of labia minora reduction is safe and carries a great satisfaction rate among patients. CONCLUSION: We believe that a visual description of a simple and quick technique will help standardized patient care and achieve good outcomes.


Assuntos
Procedimentos Cirúrgicos em Ginecologia/métodos , Vulva/cirurgia , Dispareunia/etiologia , Dispareunia/cirurgia , Feminino , Humanos , Hipertrofia/cirurgia , Vulva/patologia
11.
Gynecol Obstet Fertil Senol ; 49(12): 913-922, 2021 12.
Artigo em Francês | MEDLINE | ID: mdl-33639282

RESUMO

INTRODUCTION: The digestive involvement of endometriosis accounts for up to 20-25% of deep localisations. Precise mapping of digestive lesions is essential in order to plan surgery and specialized teams. The aim of this study is to assess the contribution of the MRI-coloscan couple in the preoperative assessment of digestive endometriosis. METHODS: We analyzed 45 files of patients referred for suspected digestive endometriosis. They had all undergone a preoperative MRI and coloscan associated with surgery throughout the year. We first compared the data collected in imaging, and then compared the synthesis of this data with the surgical procedure performed. RESULTS: 35 patients required digestive surgery. 24 of 45 files were concordant in MRI and coloscanner. Data from MRI alone matched with surgery in 69% of cases, against 84% for the coloscan. The synthesis allowed a concordance of 89%. 25 segmental resections, 2 discoid and 16 shaving were performed. The use of coloscan made up for nine extra cases: the detection of four additional cases of multifocality, a single undiagnosed case of a deep lesion, and allowed to specify the depth of the involvement in four cases. On the contrary, the MRI was correct compared to the CT in four cases. The presence of a digestive surgeon was necessary in 53% of cases. CONCLUSION: In the era of imaging staging, it would seem interesting to turn towards a subclassification of the digestive involvement of endometriosis in order to decide which surgery to perform. In our experience, the coloscan is a useful complement of MR, especially to assess the depth of involvement and the multifocality.


Assuntos
Procedimentos Cirúrgicos do Sistema Digestório , Endometriose , Laparoscopia , Cirurgiões , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Endometriose/complicações , Endometriose/diagnóstico por imagem , Endometriose/cirurgia , Feminino , Humanos , Laparoscopia/métodos , Imageamento por Ressonância Magnética/métodos , Pelve/diagnóstico por imagem , Pelve/patologia
12.
J Gynecol Obstet Hum Reprod ; 49(6): 101684, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31926349

RESUMO

INTRODUCTION: Vaginal mesh has been proven to be an effective aid in the treatment of cystocele. Could an ambulatory approach be feasible for the Uphold Lite®-mesh? HYPOTHESIS: We investigate the feasibility of an ambulatory approach of Uphold Lite® insertion in a well-selected population. Risk factors for a non-successful ambulatory approach are identified. METHODOLOGY: We conducted a retrospective case series of 236 women who underwent Uphold Lite® vaginal mesh insertion for the treatment of pelvic organ prolapse at our center. Indications for surgery were symptomatic anterior and/or apical prolapse, stages POPQ≥2. We compared women having an ambulatory approach, to those having a one day hospitalization planned but needed to stay. Comparisons between percentages were calculated using the chi-square or Fisher's exact test, depending on the number of women in each group. The mean comparisons were performed using the Student t-test, and the median test comparisons by the Kruskal-Wallis test. A difference was considered significant if p<0.05. RESULTS: The most common reason for staying (85.7% of all ambulatory failures) after Uphold® surgery is the presence of an elevated post void residual. This complication was more found in the following: surgery in the afternoon, use of high-dose morphinics in general anesthesia, and in women with a higher parity. CONCLUSIONS: Our study shows that Uphold® surgery in a one-day setting is feasible and safe. Women desiring this approach should be counselled on the 42.6% risk of one-day failure though, mostly due to non-validation of a post void residual. General anesthesia with high-dose morphinics, a higher parity, and surgery in the afternoon are risk factors for failure of an ambulatory protocol.


Assuntos
Procedimentos Cirúrgicos Ambulatórios/métodos , Procedimentos Cirúrgicos em Ginecologia/métodos , Prolapso de Órgão Pélvico/cirurgia , Telas Cirúrgicas/estatística & dados numéricos , Vagina/cirurgia , Idoso , Procedimentos Cirúrgicos Ambulatórios/efeitos adversos , Estudos de Viabilidade , Feminino , Procedimentos Cirúrgicos em Ginecologia/efeitos adversos , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Telas Cirúrgicas/efeitos adversos , Resultado do Tratamento
13.
J Gynecol Obstet Hum Reprod ; 48(9): 781-783, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30898625

RESUMO

Uterine fibroids are the most common form of benign gynaecological tumors in women of childbearing age Piecak et al. (2017) [1]. These uterine fibroids can be responsible for abnormal uterine bleeding, pelvic pain, pelvic pressure and infertility Pritts et al. (2009), Ali and Al-Hendy (2017) [2,3]. Their treatment can be carried out according to several methods: medical treatment, uterine artery embolization or surgery (myomectomy or hysterectomy). Although surgery is the main option, there are medical treatments to reduce their size and decrease and control their symptoms. Ulipristal acetate (UPA) has been the first selective progesterone-receptor modulator approved for the preoperative and long-term treatment for uterine fibroids Ferrero et al. (2018) [4]. Here we present the case of a 38-years-old patient whose large fibroma (initially treated with UPA) totally disappeared after pregnancy.


Assuntos
Leiomioma/terapia , Neoplasias Uterinas/terapia , Adulto , Contraceptivos Hormonais/uso terapêutico , Feminino , Humanos , Leiomioma/diagnóstico por imagem , Imageamento por Ressonância Magnética , Norpregnadienos/uso terapêutico , Gravidez , Remissão Espontânea , Neoplasias Uterinas/diagnóstico por imagem
14.
Eur J Obstet Gynecol Reprod Biol ; 242: 139-143, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31586880

RESUMO

BACKGROUND: Our study aimed at understanding the influence of healing time on the mechanical properties of meshes used in pelvic organ prolapse, once implanted in an animal model using the rat. METHODS: A standard polypropylene mesh was implanted in 42 rats in order to evaluate the mechanical properties of the implanted mesh. Explantation occurred at 1, 2, 3, 4 and 5 months and mechanical tests were performed. Each sample was mechanically evaluated by a uniaxial tensile test with a machine (BIOTENS). Biological tissues presented a nonlinear relation between stress and strain so it could be modeled by the 2 parameters C0 and C1 of a second-order Mooney-Rivlin law. RESULTS: The rigidity in small deformation might not be affected by healing time or the presence of the synthetic implant. On the contrary, changes seemed to occur on the stiffness in large deformation (C1). The stiffness with the mesh composite changed with healing time. The "two-month implantation" rat group was significantly more rigid than the two control groups (pcontrol/2months = 0,04 and pplacebo/2months = 0,04). The 2- and 3-month healing groups were significantly more rigid than the 1-month healing group (p1/2months = 0,01 and p1/3months = 0,003). After 2 months, the mechanical properties seemed to stabilize (p2/3months = 0,44, p2/5months = 0,16 et p3/5months = 0,3). CONCLUSION: In order to evaluate the mechanical properties of an implanted mesh, the optimal time for explantation seems to be 2 months. Once this period is over, a more physiological mesh will be developed in order to be similar to native vaginal tissue once implanted and colonized by scar tissue.


Assuntos
Prolapso de Órgão Pélvico/cirurgia , Telas Cirúrgicas/efeitos adversos , Animais , Masculino , Teste de Materiais , Ratos Wistar , Fatores de Tempo
15.
J Gynecol Obstet Hum Reprod ; 48(4): 235-239, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29908951

RESUMO

INTRODUCTION: The management of posterior deep endometriosis is not consensual. This is due to a great heterogeneity of data from the literature. Many series were small and overall, predictors of pregnancy were not all included and analyzed by multivariate analysis. We conducted this study to evaluate the factors associated with pregnancy during the first two in vitro fertilization (IVF) attempts in infertile women with posterior deep endometriosis. MATERIAL AND METHODS: 230 women were included in this retrospective observational study, between January 1st, 2007 and September 30th, 2013, at the University Hospital of Lille. A large set of variables were recorded and their association with the chance of pregnancy was analyzed by multivariate analysis (MVA), including patients' features, endometriosis items, surgery procedures and IVF data. RESULTS: After 2 IVF attempts, 48.7% of the 230 women achieved a pregnancy, including 39.1% of ongoing pregnancies. Logistic regression analysis retained five variables significantly associated to the chance of pregnancy: oocyte retrieval number (OR=0.468 (0.296-0.739) p=0.001), age (OR=0.888 (0.811-0.974) p=0.011), single embryo transfer number (OR=1.494 (1.036-2.153) p=0.031), presence of a recto-uterine nodule (OR=0.454 (0.235-0.877) p=0.019) and IVF technique (OR=0.509 (0.272-0.951) p=0.034). CONCLUSION: The presence of a recto uterine nodule is associated with a lower chance of pregnancy after IVF. It has to be checked by prospective studies whether the finding of a recto-uterine nodule whose pejorative effect has not been reported so far should encourage to perform surgery before IVF in patients with deep endometriosis.


Assuntos
Endometriose/complicações , Fertilização in vitro , Infertilidade Feminina/etiologia , Infertilidade Feminina/terapia , Adulto , Endometriose/patologia , Endometriose/cirurgia , Feminino , Humanos , Imageamento por Ressonância Magnética , Recuperação de Oócitos , Doenças Peritoneais/complicações , Doenças Peritoneais/patologia , Doenças Peritoneais/cirurgia , Gravidez , Taxa de Gravidez , Doenças Retais/complicações , Doenças Retais/patologia , Doenças Retais/cirurgia , Estudos Retrospectivos , Transferência de Embrião Único , Resultado do Tratamento , Doenças Uterinas/complicações , Doenças Uterinas/patologia , Doenças Uterinas/cirurgia , Doenças Vaginais/complicações , Doenças Vaginais/patologia , Doenças Vaginais/cirurgia
16.
Eur J Obstet Gynecol Reprod Biol ; 136(2): 254-9, 2008 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17964059

RESUMO

OBJECTIVE: The objective was to develop an animal model using bacterial inoculation to evaluate tissue integration and tolerance to meshes used in genital prolapse surgery. STUDY DESIGN: We placed three different meshes under the abdominal skin of 120 Wistar rats: a polypropylene monofilament non-coated mesh (Parietene), a polypropylene monofilament collagen-coated mesh (Ugytex) and a polyethylene terephthalate mesh (Mersuture). We performed bacterial inoculation just after implantation with 1 ml of 10(7) colonies forming unit (CFU) of Staphylococcus epidermidis or Escherichia coli. Rats were sacrificed 7, 14, 60, and 90 days after intervention. We used polarised light microscopy to analyse the collagen deposition and organisation. We quantified the inflammation cells. Bacterial analysis and quantification of the explanted meshes were performed. The exact Fisher's test and Kruskal-Wallis test were used for statistics. RESULTS: We did not find any significant difference between inoculated or non-inoculated meshes in terms of collagen deposition. The scarring process seemed stable at day 90. Tissue integration was best with the polypropylene meshes, which allowed the development of a well-organised, mature connective tissue. Inflammatory reaction was higher in inoculated meshes, but only at day 7. At day 90, we found a high number of macrophages and multinuclear cells around all the meshes. There was no significant difference between prostheses that had been inoculated and those that had not with regard to positive bacterial culture. Quantification of bacterial colonies decreased with time. CONCLUSION: In this animal model, we did not find any clinically related difference in infection and tissue integration between the meshes used in genital prolapse. Such experimental studies must be carried out whenever new prostheses become available before their use is validated in common practice.


Assuntos
Modelos Animais de Doenças , Ratos Wistar/cirurgia , Telas Cirúrgicas/efeitos adversos , Infecção da Ferida Cirúrgica , Procedimentos Cirúrgicos Urogenitais/efeitos adversos , Animais , Cistocele/cirurgia , Infecções por Escherichia coli/etiologia , Feminino , Ratos , Infecções Estafilocócicas/etiologia , Infecção da Ferida Cirúrgica/microbiologia , Prolapso Uterino/cirurgia
17.
J Gynecol Obstet Biol Reprod (Paris) ; 37(5): 499-504, 2008 Sep.
Artigo em Francês | MEDLINE | ID: mdl-18178018

RESUMO

OBJECTIVE: Placenta accreta is a rare obstetrical pathology but leads to a high morbidity. It is likely to become increasingly frequent as the rate of cesarean section increases in developed countries. The aim of our study was to describe the diagnostic and management of patients with placenta accreta, during the last ten years, in a French high-level maternity. MATERIAL AND METHOD: This is a retrospective study of the prenatal diagnosis and management of placenta accreta with histological confirmation in our department between 1996 and 2006. RESULTS: The rate of placenta accreta in our study was 0.52 per thousand. Ninety-six percent of the patients had risk factors for placenta accreta. Placenta accreta was diagnosed in 24% of the patients by sonographic examination. Magnetic resonance imaging did not increase sensitivity. Eighty-eight percent of the patients required a hysterectomy. No digestive or urinary complications occurred. There were no maternal deaths. CONCLUSION: Despite established ultrasound and MRI-based diagnostic criteria for placenta accreta, this condition remains difficult to diagnose in the general population. Morbidity associated with this pathology is serious, especially in cases of hemostatic hysterectomy. When placenta accreta is diagnosed prior to delivery, care in a high-level maternity hospital must be considered to improve management.


Assuntos
Maternidades , Hospitais Universitários , Histerectomia , Placenta Acreta/diagnóstico , Placenta Acreta/cirurgia , Adulto , Feminino , França , Humanos , Histerectomia/métodos , Gravidez , Resultado da Gravidez , Estudos Retrospectivos , Fatores de Risco , Ultrassonografia Pré-Natal
18.
Gynecol Obstet Fertil Senol ; 46(3): 278-289, 2018 Mar.
Artigo em Francês | MEDLINE | ID: mdl-29510964

RESUMO

Surgical management of ovarian endometrioma is most often part of a global approach of endometriosis pathology. Isolated endometrioma are rare. Laparoscopic cystectomy is the gold standard for surgical management of endometrioma. Nevertheless, this technique impacts the ovarian function. The hemostasis of the ovarian cyst bed should be performed to conserve the ovarian stroma. Ultrasonography-guided cyst aspiration, laparoscopic drainage and simple bipolar coagulation are not recommended as first line of treatment. Based on the actual literature, we cannot state the place of laser-vaporization and plasma-energy ablation in surgical management. Ethanol sclerotherapy could be an alternative to treat recurrent endometrioma. Uncompleted surgical removal of endometriosis lesions increases the recurrence rate. Endometriosis management should take into account the research and treatment of all the pelvic lesion, especially before surgical management of endometrioma. In this context, the evaluation of ovarian reserve could be useful before surgery.


Assuntos
Endometriose/terapia , Doenças Ovarianas/terapia , Endometriose/complicações , Feminino , Fertilidade , Humanos , Laparoscopia , Doenças Ovarianas/complicações , Reserva Ovariana , Ovariectomia , Dor Pélvica/etiologia , Dor Pélvica/terapia , Recidiva , Escleroterapia
19.
J Gynecol Obstet Hum Reprod ; 47(6): 257-260, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29574053

RESUMO

This article reports a case of cervico-isthmic disjunction unnoticed during childhood, diagnosed in a context of primary infertility and endometriosis, and surgically treated. It is an uncommon condition. The diagnosis is most often made as part of an assessment of primary amenorrhea in a young woman with a history of severe pelvic trauma. It is suspected after imaging assessment and confirmed intraoperatively. The treatment consists in an anastomosis between the cervix and the uterine body, after individualizing these two structures, around a drain guiding healing. After this surgery, multiple pregnancies have been successfully carried out.


Assuntos
Acidentes de Trânsito , Doenças Uterinas , Útero , Adulto , Colo do Útero/lesões , Colo do Útero/patologia , Colo do Útero/cirurgia , Endometriose/diagnóstico , Feminino , Humanos , Infertilidade/diagnóstico , Imageamento por Ressonância Magnética , Doenças Uterinas/diagnóstico por imagem , Doenças Uterinas/patologia , Doenças Uterinas/cirurgia , Útero/lesões , Útero/patologia , Útero/cirurgia
20.
J Gynecol Obstet Hum Reprod ; 47(1): 1-7, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29097291

RESUMO

STUDY OBJECTIVE: To assess the value of performing a protective stoma in patients operated for rectal endometriosis. MATERIAL AND METHODS: From June 2009 to December 2011, 47 patients were operated for rectal endometriosis by segmental or discoid resection in 4 different centers. Two groups were formed: one with protective stoma (group S), n=33 and one without protective stoma (group NS), n=14. Data were collected from the CIRENDO database. MEASUREMENTS AND MAIN RESULTS: Postoperative complication rate of group NS was 57% against 48% in group S (P=0.75). There was an increasing trend of the rate of anastomotic leakage in group S as compared to group NS: 21% against 3% (P=0.073). All 3 patients of group NS with an anastomotic leakage were reoperated and the group S patient had medical treatment. In a center, digestive operative time was not necessarily performed in association with a gastrointestinal surgeon. All patients in group S had a restoration of continuity in about 3 months. Two of them had dilation of anastomotic stricture and 3 others showed a transient postoperative ileus during this recovery. Quality of life was assessed by the MOS SF-36 and significantly improved in both groups thanks to the intervention. CONCLUSION: Temporary digestive stoma in patients operated for rectal endometriosis has to be considered because in our study, it seems reducing complications such as anastomotic leakage. This must be confirmed with studies with larger numbers.


Assuntos
Procedimentos Cirúrgicos do Sistema Digestório/métodos , Endometriose/cirurgia , Avaliação de Resultados em Cuidados de Saúde , Complicações Pós-Operatórias/terapia , Doenças Retais/cirurgia , Estomas Cirúrgicos , Adulto , Fístula Anastomótica/cirurgia , Estudos de Casos e Controles , Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos , Feminino , Humanos , Reoperação , Adulto Jovem
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