Detalhe da pesquisa
1.
Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection.
Antimicrob Agents Chemother
; 67(2): e0145922, 2023 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36688684
2.
The multistate tuberculosis pharmacometric model: a semi-mechanistic pharmacokinetic-pharmacodynamic model for studying drug effects in an acute tuberculosis mouse model.
J Pharmacokinet Pharmacodyn
; 44(2): 133-141, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28205025
3.
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.
Antimicrob Agents Chemother
; 60(10): 6271-80, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27503647
4.
Combinations of ß-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection.
Antimicrob Agents Chemother
; 59(8): 4997-9, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25987618
5.
Mycobacterium tuberculosis gyrase inhibitors as a new class of antitubercular drugs.
Antimicrob Agents Chemother
; 59(4): 1868-75, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25583730
6.
Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of Mycobacterium tuberculosis Infection.
Pharmaceutics
; 14(12)2022 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36559163
7.
Identification of ß-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions.
ACS Infect Dis
; 8(3): 557-573, 2022 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35192346
8.
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis.
Sci Transl Med
; 14(643): eaaz6280, 2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35507672
9.
Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis.
Antimicrob Agents Chemother
; 54(5): 2262-4, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20160054
10.
Exploring the SAR of the ß-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
ACS Infect Dis
; 6(5): 1098-1109, 2020 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32196311
11.
X-ray-based virtual slicing of TB-infected lungs.
Sci Rep
; 9(1): 19404, 2019 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31852973
12.
Novel Pyrazole-Containing Compounds Active against Mycobacterium tuberculosis.
ACS Med Chem Lett
; 10(10): 1423-1429, 2019 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31620228
13.
Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis.
J Med Chem
; 61(24): 11327-11340, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30457865
14.
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
J Med Chem
; 61(15): 6592-6608, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29944372
15.
Basal shuttle of NF-kappaB/I kappaB alpha in resting T lymphocytes regulates HIV-1 LTR dependent expression.
Retrovirology
; 4: 56, 2007 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-17686171
16.
TRAF family proteins link PKR with NF-kappa B activation.
Mol Cell Biol
; 24(10): 4502-12, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15121867
17.
Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.
Sci Rep
; 7(1): 9430, 2017 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28842600
18.
Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).
J Med Chem
; 60(19): 8011-8026, 2017 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28953378
19.
N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity.
ChemMedChem
; 11(7): 687-701, 2016 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26934341
20.
THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria.
Nat Microbiol
; 1: 15006, 2016 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27571973