Detalhe da pesquisa
1.
AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia.
Haematologica
; 107(6): 1311-1322, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34732043
2.
Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models.
Haematologica
; 105(3): 697-707, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31123034
3.
Role of MSC-derived galectin 3 in the AML microenvironment.
Biochim Biophys Acta Mol Cell Res
; 1865(7): 959-969, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29655803
4.
Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia.
Blood
; 128(9): 1260-9, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27268264
5.
Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival.
Haematologica
; 103(5): 810-821, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29545342
6.
Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells.
Biochim Biophys Acta
; 1863(4): 562-71, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26704388
7.
Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.
Blood
; 126(3): 363-72, 2015 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26045609
8.
Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms.
Haematologica
; 102(12): 2048-2057, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28912176
9.
The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells.
Biochim Biophys Acta
; 1843(9): 1969-77, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24858343
10.
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.
Cancer Cell
; 10(5): 375-88, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17097560
11.
Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia.
Leukemia
; 38(4): 729-740, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38148395
12.
Chromatin Profiles Are Prognostic of Clinical Response to Bortezomib-Containing Chemotherapy in Pediatric Acute Myeloid Leukemia: Results from the COG AAML1031 Trial.
Cancers (Basel)
; 16(8)2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38672531
13.
Targeting Unc51-like Autophagy Activating Kinase 1 (ULK1) Overcomes Adaptive Drug Resistance in Acute Myelogenous Leukemia.
Mol Cancer Res
; 21(6): 548-563, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36787422
14.
Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias.
Sci Adv
; 9(48): eadh1436, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38019903
15.
Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: involvement of the bioactive sphingolipid ceramide.
J Biol Chem
; 286(2): 1301-11, 2011 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-20974858
16.
Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia.
Signal Transduct Target Ther
; 7(1): 51, 2022 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35185150
17.
Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells.
J Cell Biochem
; 112(6): 1696-707, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21360576
18.
Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.
Leukemia
; 35(9): 2469-2481, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34127794
19.
LGALS1 acts as a pro-survival molecule in AML.
Biochim Biophys Acta Mol Cell Res
; 1867(10): 118785, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32590026
20.
LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML.
EBioMedicine
; 44: 126-137, 2019 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-31105032