[Complex therapy and prevention of exacerbations of calculous pyelo- nephritis].

Urolithiasis in Russia still occupies one of the leading places in the total number of urological nosologies. Acute and chronic calculous pyelonephritis is the most severe complication of urolithiasis, causing destructive kidney damage in the form of apostematous pyelonephritis, abscess, kidney carbuncle and pionephrosis. In the case of acute obstruction of the urinary tract by concretion, purulent kidney damage occurs in a very short period of time and the result of treatment in this case depends on the adequacy and speed of the choice of the method of drainage of the urinary tract, that is, the elimination of their obstruction, as well as the correct choice of rational antibacterial therapy. The article presents three clinical observations of effective treatment of patients with chronic calculous pyelonephritis with Phytolysin paste and Phytosilin capsules as part of complex therapy.

[Cytomegalovirus Infection and Endothelial Function in Patients With Acute Myocardial Infarction].

PURPOSE: to study elucidate association of active cytomegalovirus (CMV) infection with endothelial dysfunction in patients with acute myocardial infarction (AMI). MATERIALS AND METHODS: The study included 42 volunteers without ischemic heart disease (IHD) and 63 patients with AMI. Blood samples for analysis of the deoxyribonucleic acid (DNA) of CMV in plasma by real-time polymerase chain reaction were taken in patients - before coronary angiography, in volunteers - at admission. In addition, in patients with AMI and volunteers without IHD, endothelial function was analyzed using endothelium-dependent vasodilatation (EDVD) test of the brachial artery. RESULTS: We showed that in patients with AMI, the concentration of CMV DNA in plasma was statistically significantly increased when compared with that in volunteers without IHD, which reflects active CMV infection - 1185.7 (0; 3003.0) vs. 0 (0; 910.8) copies of DNA / ml plasma (p=0.011). In comparison with volunteers without IHD, patients with AMI also more often had endothelial dysfunction - 11.5 (7.5, 15.2) % vs. 4.4 (0; 9.6) % of cases (p.

Acetylsalicylic Acid Produces Different Effects on the Production of Active Oxygen Species by Activated Platelets in Different Inflammatory Diseases.

We studied the effect of acetylsalicylic acid on ROS generation by platelets in patients after surgical interventions and in patients with bronchial asthma was studied. Platelets stimulated with platelet-activating factor are characterized by weak luminol-enhanced chemiluminescence in healthy people and patients after operations with laparoscopic incisions. Addition of platelet activation factor to platelet samples from patients after open abdominal surgery caused intensive chemiluminescence that was suppressed after platelet incubation with acetylsalicylic acid. At the same time, platelets of patients with aspirin-sensitive asthma did not respond to addition of platelet activating factor, but after incubation with acetylsalicylic acid, an intensive burst of chemiluminescence was detected with a maximum in 5-10 sec after the addition of a platelet-activating factor. In patients with bronchial asthma tolerant to aspirin, platelet activation factor did not induce chemiluminescence irrespective of incubation with acetylsalicylic acid.