1.
Bioorg Med Chem Lett
; 18(6): 1840-4, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18295483
RESUMO
Based on a pharmacophore hypothesis substituted tetramic and tetronic acid 3-carboxamides as well as dihydropyridin-2-one-3-carboxamides were investigated as inhibitors of undecaprenyl pyrophosphate synthase (UPPS) for use as novel antimicrobial agents. Synthesis and structure-activity relationship patterns for this class of compounds are discussed. Selectivity data and antibacterial activities for selected compounds are provided.