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Neuroepidemiology ; 54(4): 343-355, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32200380

RESUMO

BACKGROUND: We explored the association between ionizing radiation (IR) from pre-natal and post-natal radio-diagnostic procedures and brain cancer risk within the MOBI-kids study. METHODS: MOBI-kids is an international (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, New Zealand, Spain, The Netherlands) case-control study including 899 brain tumor (645 neuroepithelial) cases aged 10-24 years and 1,910 sex-, age-, country-matched controls. Medical radiological history was collected through personal interview. We estimated brain IR dose for each procedure, building a look-up table by age and time period. Lifetime cumulative doses were calculated using 2 and 5 years lags from the diagnostic date. Risk was estimated using conditional logistic regression. Neurological, psychological and genetic conditions were evaluated as potential confounders. The main analyses focused on neuroepithelial tumors. RESULTS: Overall, doses were very low, with a skewed distribution (median 0.02 mGy, maximum 217 mGy). ORs for post-natal exposure were generally below 1. ORs were increased in the highest dose categories both for post and pre-natal exposures: 1.63 (95% CI 0.44-6.00) and 1.55 (0.57-4.23), respectively, based on very small numbers of cases. The change in risk estimates after adjustment for medical conditions was modest. CONCLUSIONS: There was little evidence for an association between IR from radio-diagnostic procedures and brain tumor risk in children and adolescents. Though doses were very low, our results suggest a higher risk for pre-natal and early life exposure, in line with current evidence.


Assuntos
Neoplasias Encefálicas/epidemiologia , Exposição Ambiental/estatística & dados numéricos , Neoplasias Induzidas por Radiação/epidemiologia , Efeitos Tardios da Exposição Pré-Natal/epidemiologia , Doses de Radiação , Radiografia/estatística & dados numéricos , Adolescente , Adulto , Neoplasias Encefálicas/etiologia , Estudos de Casos e Controles , Criança , Feminino , Humanos , Imageamento por Ressonância Magnética/efeitos adversos , Imageamento por Ressonância Magnética/estatística & dados numéricos , Masculino , Neoplasias Induzidas por Radiação/etiologia , Gravidez , Radiografia/efeitos adversos , Adulto Jovem
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