Detalhe da pesquisa
1.
CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy.
J Chem Inf Model
; 59(4): 1472-1485, 2019 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30908019
2.
Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance.
Exp Cell Res
; 318(10): 1146-59, 2012 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22484375
3.
Factors influencing the antifolate activity of synthetic tea-derived catechins.
Molecules
; 18(7): 8319-41, 2013 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23863773
4.
From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia.
Nat Commun
; 14(1): 3079, 2023 05 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37248212
5.
4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.
Mol Cancer Ther
; 2023 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38064712
6.
CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation.
J Med Chem
; 65(7): 5660-5674, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35348328
7.
Binding of natural and synthetic polyphenols to human dihydrofolate reductase.
Int J Mol Sci
; 10(12): 5398-5410, 2009 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20054477
8.
Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain.
Antiviral Res
; 162: 79-89, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30557576
9.
Crystal structures of Lymphocytic choriomeningitis virus endonuclease domain complexed with diketo-acid ligands.
IUCrJ
; 5(Pt 2): 223-235, 2018 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29765612
10.
Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.
Nat Commun
; 8(1): 1420, 2017 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29127277
11.
Enzymatic synthesis of acyclic nucleoside thiophosphonate diphosphates: effect of the α-phosphorus configuration on HIV-1 RT activity.
Antiviral Res
; 117: 122-31, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25766862
12.
Suppression of antifolate resistance by targeting the myosin Va trafficking pathway in melanoma.
Neoplasia
; 15(7): 826-39, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23814494
13.
Directed phenotype switching as an effective antimelanoma strategy.
Cancer Cell
; 24(1): 105-19, 2013 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23792190
14.
Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation.
PLoS One
; 7(12): e52231, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23251702
15.
Comparison of a pair of synthetic tea-catechin-derived epimers: synthesis, antifolate activity, and tyrosinase-mediated activation in melanoma.
ChemMedChem
; 6(3): 440-9, 2011 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21302360