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Bioorg Med Chem Lett
; 20(1): 359-61, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19913412
RESUMO
Potent antimalarial compound artemisinin, 1 was bio-transformed to C-9 acetoxy artemisinin, 2 using soil microbe Penicillium simplissimum along with C-9 hydroxy derivative 3. The products were characterized using high field NMR and MS-MS data. The absolute stereochemistry of the newly generated chiral centers has been ascertained by COSY and 1D NOESY experiments. This is the first Letter of direct C-acetoxylation of artemisinin using microbial strains.