Detalhe da pesquisa
1.
Identification of a µ-δ opioid receptor heteromer-biased agonist with antinociceptive activity.
Proc Natl Acad Sci U S A
; 110(29): 12072-7, 2013 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23818586
2.
Small-molecule proteostasis regulators for protein conformational diseases.
Nat Chem Biol
; 8(2): 185-96, 2011 Dec 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22198733
3.
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7).
Bioorg Med Chem Lett
; 22(23): 7135-41, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23079522
4.
Label-free LC-MS based assay to characterize small molecule compound binding to cells.
SLAS Discov
; 27(7): 405-412, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36064100
5.
Global consequences of activation loop phosphorylation on protein kinase A.
J Biol Chem
; 285(6): 3825-3832, 2010 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19965870
6.
High-Throughput Mass Spectrometry for Hit Identification: Current Landscape and Future Perspectives.
SLAS Discov
; 26(2): 168-191, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33482074
7.
Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening.
Mol Pharmacol
; 77(1): 46-57, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19837904
8.
High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.
Bioorg Med Chem
; 17(3): 990-1005, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18358729
9.
Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries.
Bioorg Med Chem
; 17(14): 5027-37, 2009 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19553129
10.
De novo discovery of serotonin N-acetyltransferase inhibitors.
J Med Chem
; 50(22): 5330-8, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17924613
11.
Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates.
J Med Chem
; 50(22): 5357-63, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17918823
12.
An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C).
SLAS Discov
; 22(1): 21-31, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27628691
13.
Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites.
Structure
; 11(8): 985-96, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12906829
14.
Development of photo-crosslinking reagents for protein kinase-substrate interactions.
FEBS Lett
; 520(1-3): 156-60, 2002 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12044889
15.
Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
Chembiochem
; 9(16): 2606-11, 2008 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-18821554
16.
Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs.
ACS Chem Biol
; 8(10): 2164-72, 2013 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23978166
17.
Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease.
J Med Chem
; 56(2): 534-46, 2013 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23231439
18.
Small molecule activators of TRPML3.
Chem Biol
; 17(2): 135-48, 2010 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20189104
19.
NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-ß-Lactamase: Synthesis and Structure-Activity Studies.
ACS Med Chem Lett
; 1(4): 150-154, 2010 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20625539
20.
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.
Chem Biol
; 17(5): 471-82, 2010 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20534345