RESUMO
BACKGROUND: Severity of systemic lesions and mortality of experimental acute pancreatitis (AP) are reduced after pancreatic enzyme content reduction induced by cerulein administration. Octreotide has been used both prophylatically and therapeutically in AP. The possible effects of octreotide on pancreatic enzyme content and its influence on pulmonary lesions of experimental AP were assessed in this study. METHODS: Wistar male rats were divided in two branches: BRANCH I - Animals divided into three groups: Group Sa (n = 10) intravenous saline infusion; Group Ce (n = 10) intravenous cerulein infusion, (0.133 micro g/kg(-1).h(-1)) and Group Oc (n = 10) SC octreotide (10 micro g/kg(-1)). Trypsin, elastase and amylase pancreatic contents as well as serum amylase were determined thereafter in all three groups; BRANCH II - Rats treated as in branch I, were submitted to sodium taurocholate AP (Groups Sa+AP, Ce+AP and Oc+AP). Two hours thereafter amylase and TAP assays were performed in serum, ascites and pancreatic tissue in eight animals of each group. Pulmonary histology was studied by morphometry 24 h after AP in the remaining animals. RESULTS: Increased serum amylase and pancreatic enzyme contents were observed in octreotide-treated animals when compared to animals receiving saline or cerulein. After AP increases of serum and ascitic fluid amylase and of pancreatic TAP were observed in octreotide pre-treated animals when compared to saline and cerulein groups. Pulmonary interstitial and alveolar edema after AP was significantly increased in rats receiving octreotide as compared to the cerulein group. CONCLUSION: Octreotide administration acutely increases the enzymatic content of the pancreas and thus may have a potential deleterious influence in the evolution of AP.
Assuntos
Fármacos Gastrointestinais/uso terapêutico , Octreotida/uso terapêutico , Pancreatite/tratamento farmacológico , Doença Aguda , Amilases/metabolismo , Animais , Líquido Ascítico/metabolismo , Ceruletídeo/administração & dosagem , Ceruletídeo/uso terapêutico , Modelos Animais de Doenças , Quimioterapia Combinada , Fármacos Gastrointestinais/administração & dosagem , Injeções Intravenosas , Masculino , Octreotida/administração & dosagem , Pâncreas/efeitos dos fármacos , Pâncreas/enzimologia , Elastase Pancreática/metabolismo , Pancreatite/enzimologia , Pancreatite/patologia , Edema Pulmonar/induzido quimicamente , Edema Pulmonar/tratamento farmacológico , Edema Pulmonar/patologia , Ratos , Ratos Wistar , Ácido Taurocólico/farmacologia , Tripsina/metabolismoRESUMO
Os autores estudaram 51 pacientes portadores de abscesso hepatico piogenico tratados na Disciplina de Cirurgia do Aparelho Digestivo do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo no periodo entre 1975 e 1992. A idade dos pacientes variou entre 13 e 77 anos, com media de 43 anos, sendo 54,9 por cento do sexo feminino. O sintoma mais frequente foi febre, presente em 100 por cento dos pacientes. Dor abdominal, ictericia e hepatomegalia estiveram presentes em 58,8 por cento, 39,2 por cento e 35,3 por cento dos pacientes, respectivamente. Vinte e oito pacientes (55 por cento) apresentavam leucocitose, 45 por cento apresentavam elevacao de bilirrubinas e 35,3 por cento apresentavam elevacao de fosfatase alcalina....